Publication

Method and compositions for inhibition of macrophage migration inhibitory factor (mif)

Hilal Lashuel, Hajer Ouertatani-Sakouhi
2011
Patents

Résumé

The present invention relates to methods for inhibition of tautomerase activity of macrophage migration inhibitory factor (MIF). The invention further relates to substances for irreversibly covalently binding to MIF for inhibition of tautomerase activity.

Source officielle

https://infoscience.epfl.ch/entities/publication/1f1cd1cc-9933-42fc-a1c7-fbf3884e1dcb

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Hilal Lashuel, Hajer Ouertatani-Sakouhi
2011
Patents

Résumé

Source officielle

https://infoscience.epfl.ch/entities/publication/1f1cd1cc-9933-42fc-a1c7-fbf3884e1dcb

À propos de ce résultat

Concepts associés (9)

Binding site

In biochemistry and molecular biology, a binding site is a region on a macromolecule such as a protein that binds to another molecule with specificity. The binding partner of the macromolecule is often referred to as a ligand. Ligands may include other proteins (resulting in a protein-protein interaction), enzyme substrates, second messengers, hormones, or allosteric modulators. The binding event is often, but not always, accompanied by a conformational change that alters the protein's function.

Interaction non covalente

Une interaction non covalente diffère d'une liaison covalente en ce qu'elle n'implique pas le partage d'électrons, mais implique plutôt des variations plus dispersées des interactions électromagnétiques entre molécules ou au sein d'une molécule. L' énergie chimique libérée lors de la formation d'interactions non covalentes est généralement de l'ordre de 1 à 5 kcal / mol ( à pour 6,02 × 1023 molécules). Les interactions non covalentes peuvent être classées en différentes catégories, telles que les effets électrostatiques, les effets π, les forces de van der Waals et les effets hydrophobes.

Molecular binding

Molecular binding is an attractive interaction between two molecules that results in a stable association in which the molecules are in close proximity to each other. It is formed when atoms or molecules bind together by sharing of electrons. It often, but not always, involves some chemical bonding. In some cases, the associations can be quite strong—for example, the protein streptavidin and the vitamin biotin have a dissociation constant (reflecting the ratio between bound and free biotin) on the order of 10−14—and so the reactions are effectively irreversible.

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Polyanionic Amphiphilic Dendritic Polyglycerols as Broad-Spectrum Viral Inhibitors with a Virucidal Mechanism

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