Publications associées à Aging and matrix viscoelasticity affect multiscale tendon properties and tendon derived cell behavior

Bio-Enhanced Neoligaments Graft Bearing FE002 Primary Progenitor Tenocytes: Allogeneic Tissue Engineering & Surgical Proofs-of-Concept for Hand Ligament Regenerative Medicine

Sandra Jaccoud, Nathalie Hirt-Burri, Philippe Abdel Sayed, Corinne Scaletta, Lee Ann Laurent-Applegate, Laurent Alexis Clément Vannay, Joachim Meuli, Cédric Peneveyre, Alexis Laurent, Annick Jeannerat, Axelle Thomas

Hand tendon/ligament structural ruptures (tears, lacerations) often require surgical reconstruction and grafting, for the restauration of finger mechanical functions. Clinical-grade human primary progenitor tenocytes (FE002 cryopreserved progenitor cell so ...

MDPI2023

Micro- and nanostructure specific X-ray tomography reveals less matrix formation and altered collagen organization following re duce d loading during Achilles tendon healing

Marianne Liebi

Recovery of the collagen structure following Achilles tendon rupture is poor, resulting in a high risk for re-ruptures. The loading environment during healing affects the mechanical properties of the tendon, but the relation between loading regime and heal ...

Elsevier Sci Ltd2023

Engineered substrates incapable of induction of chondrogenic differentiation compared to the chondrocyte imprinted substrates

Philippe Renaud, Shahin Bonakdar, Leila Montazeri, Zahrasadat Ghazali

It is well established that surface topography can affect cell functions. However, finding a reproducible and reliable method for regulating stem cell behavior is still under investigation. It has been shown that cell imprinted substrates contain micro- an ...

IOP Publishing Ltd2023

An Off-the-Shelf Tissue Engineered Cartilage Composed of Optimally Sized Pellets of Cartilage Progenitor/Stem Cells

Dominique Pioletti, Weiliang Shen, Jiayun Huang

Articular cartilage focal lesion remains an intractable challenge in sports medicine, and autologous chondrocytes' implantation (ACI) is one of the most commonly utilized treatment modality for this ailment. However, the current ACI technique requires two ...

AMER CHEMICAL SOC2021

Wireless soft microscale actuators and robotic devices to study mechanobiology

Raquel Filipa Penacho Parreira

Tissues morphogenesis and homeostasis involve the spatiotemporal regulation of mechanics at multiple scales. Characterization of mechanical properties of biological systems as well as investigating the effects of mechanical forces on biological function ar ...

EPFL2021

Gold nanoparticles as a new tool in amyloid studies

Urszula Beata Cendrowska

The misfolding and self-assembly of proteins into fibrils is a hallmark of several neurodegenerative and systemic diseases. These disease-associated proteins have the propensity to form fibrils with a cross-Î² sheet structure, called amyloids. Amyloids can ...

EPFL2020

The secreted protease Adamts18 links hormone action to activation of the mammary stem cell niche

Philipp Bucher, Cathrin Brisken, Renuga Devi Rajaram, Giovanna Ambrosini, Marian Caikovski, Rachel Marcone, Céline Berthe Constantin, Dalya Ataca, Marie Shamseddin, Patrik Aouad, Csaba Ferenc László

Estrogens and progesterone control breast development and carcinogenesis via their cognate receptors expressed in a subset of luminal cells in the mammary epithelium. How they control the extracellular matrix, important to breast physiology and tumorigenes ...

Nature Research2020

Mechanical properties and cytocompatibility of dense and porous Zn produced by laser powder bed fusion for biodegradable implant applications

Andreas Mortensen, Ludger Weber, Karel Lietaert

In this work, the macrotexture of dense Zn produced by laser powder bed fusion (LPBF) was studied and the mechanical properties for different tensile bar orientations were measured. The compressive strength of LPBF Zn scaffolds with five different unit cel ...

ELSEVIER SCI LTD2020

Adamts18 Function in Mammary Gland Development

Dalya Ataca

Ovarian hormones control mammary gland development and impinge on breast carcinogenesis acting via their cognate receptors in the luminal epithelium. The extracellular matrix has a key role in physiology and disease but how the two are linked is poorly und ...

EPFL2019

Understanding semiconductor nanostructures via advanced electron microscopy and spectroscopy

Reza Zamani

Transmission electron microscopy (TEM) offers an ample range of complementary techniques which are able to provide essential information about the physical, chemical and structural properties of materials at the atomic scale, and hence makes a vast impact ...

IOP PUBLISHING LTD2019

Efficient decellularization of equine tendon with preserved biomechanical properties and cytocompatibility for human tendon surgery indications

Dominique Pioletti, Nathalie Hirt-Burri, Lee Ann Laurent-Applegate, Anthony Grognuz, Cédric Peneveyre, Jens Antons, Pierre-Arnaud Aeberhard

Chronic and acute tendon injuries are frequent afflictions, for which treatment is often long and unsatisfactory. When facing extended injuries, matrices and scaffolds with sufficient biomechanical properties are required for surgical repair and could addi ...

2020

Sterol regulatory element binding protein 1 couples mechanical cues and lipid metabolism

Giovanni Sorrentino

Sterol regulatory element binding proteins (SREBPs) are a family of transcription factors that regulate lipid biosynthesis and adipogenesis by controlling the expression of several enzymes required for cholesterol, fatty acid, triacylglycerol and phospholi ...

Springer2019

Cyclodextrin Modulated Type I Collagen Self-Assembly to Engineer Biomimetic Cornea Implants

Francesco Stellacci, Evangelia-Nefeli Athanasopoulou

Collagen-rich tissues in the cornea exhibit unique and highly organized extracellular matrix ultrastructures, which contribute to its high load-bearing capacity and light transmittance. Corneal collagen fibrils are controlled during development by small le ...

WILEY-V C H VERLAG GMBH2018

Scanning Probe Microscopy Characterization of Organic Self-Assembled Monolayers

Evangelia-Nefeli Athanasopoulou

As technology advances, surface coatings become more and more important to assure materials performances. In recent years, molecular coatings have found larger acceptance and uses. Among them, self-assembled monolayers (SAMs) are attractive because they ar ...

EPFL2018

Alignment of collagen fiber in knitted silk scaffold for functional massive rotator cuff repair

Dominique Pioletti, Ting Zhu, Weiliang Shen, Jiayun Huang

Rotator cuff tear is one of the most common types of shoulder injuries, often resulting in pain and physical debilitation. Allogeneic tendon-derived decellularized matrices do not have appropriate pore size and porosity to facilitate cell infiltration, whi ...

Elsevier2017

T-cell surface modification with synthetic nanomaterials for cell-mediated delivery to the central nervous system

Maxime Ayer

The future of medicine lies in therapeutic approaches that can specifically target sites of disease and induce a localized and effective therapeutic effect. Cell-mediated delivery, especially using cells of the circulatory repertoire such as T lymphocytes, ...

EPFL2017

Stability enhancement using hyaluronic acid gels for delivery of human fetal progenitor tenocytes

Dominique Pioletti, Alain Farron, Corinne Scaletta, Lee Ann Laurent-Applegate, Anthony Grognuz

Tendon afflictions are very common, and their negative impact is high both at the workplace and in leisure activities. Tendinopathies are increasing in prevalence and can lead to tendon ruptures, where healing is a long process with outcomes that are often ...

2016

Mechanical and Functional Study of Cell Physiology at the Nanoscale

Pascal Damian Odermatt

By live-cell imaging of biological samples dynamic cellular processes can be resolved. Fluorescence microscopy (FM) and atomic force microscopy (AFM) are both capable of imaging live cells. By combining these techniques structural as well as functional inf ...

EPFL2016

Novel interventions to recover the regenerative capacity of aged skeletal muscle by targeting the interactions in the stem cell niche

Laura Lukjanenko

The remarkable ability of skeletal muscle to regenerate upon injury is conferred by tissue-resident stem cells called satellite cells. With age, the regenerative capacity of muscle stem cells (MuSCs) dramatically declines. Developing strategies to enhance ...

EPFL2016

Tissue engineering for prenatal applications

Anna-Sofia Johanna Kiveliö

Fetal therapies have become available for a restricted number of life-threatening clinical conditions. Harnessing tissue engineering for prenatal applications has not been widely pursued even though isolating cells from fetal and extraembryonic tissues has ...

EPFL2015