Publications associées à Alternative Approaches to Vertebrate Ecotoxicity Tests in the 21st Century: A Review of Developments Over the Last 2 Decades and Current Status

The Bioaccumulation of Ionizable Organic Compounds in Fish Cell Lines

Bioaccumulation is defined as the enrichment of a compound in an organism relative to the surrounding water or its food, and is an important endpoint in chemical risk assessment. Under laboratory conditions, bioaccumulation is measured as bioconcentration ...

EPFL2023

Safety risk management in University laboratories

Anastasia Jung

Risk management has become an essential element in the functioning of modern society. Correct risk identification and assessment are undoubtedly crucial to improving overall safety; nevertheless, often, it is accompanied by the wrong selection of correctiv ...

EPFL2023

Safety climate in university laboratories. Part I: model development and practical application

Thierry Meyer, Anastasia Jung

Safety climate assessment has become a regular practice for most organisations. However, it is often limited to questionnaires, providing only qualitative information. The indicator-based approach takes precedence over decision-making, and practical risk a ...

2023

Combining European and US risk prediction models with polygenic risk scores to refine cardiovascular prevention: the CoLaus|PsyCoLaus Study

Stéphane Fournier, Roxane De La Harpe, Jacques Fellay, Christian Axel Wandall Thorball

Lay Summary The aim of this study is to determine whether using polygenic risk scores improves the prediction of atherosclerotic cardiovascular disease risk when combined with clinical scores currently recommended by European and US guidelines on cardiovas ...

OXFORD UNIV PRESS2023

The development, validation and use of an interprofessional project management questionnaire in engineering education

Marc Laperrouza, Roland John Tormey

Professional skills of project planning, risk analysis, ethical design, communication, and working in interprofessional teams are now recognised as core engineering skills. Frequently, they are addressed in engineering education through team projects. Howe ...

2023

Space Oddity? A Statistical Formulation of Conjunction Assessment

Anthony Christopher Davison, Soumaya Elkantassi

Satellite conjunctions involving "near misses" of space objects are becoming increasingly likely. One approach to risk analysis for them involves the computation of the collision probability, but this has been regarded as having some counterintuitive prope ...

AMER INST AERONAUTICS ASTRONAUTICS2022

Crash test-based assessment of injury risks for adults and children when colliding with personal mobility devices and service robots

Aude Billard, Diego Felipe Paez Granados

Autonomous mobility devices such as transport, cleaning, and delivery robots, hold a massive economic and social benefit. However, their deployment should not endanger bystanders, particularly vulnerable populations such as children and older adults who ar ...

Nature Publishing Group2022

Biomechanical Measures for Fall Risk Assessment and Fall Detection in People with Transfemoral Amputations for the Next-Generation Prostheses: A Scoping Review

Silvestro Micera

Introduction: Transfemoral amputations are known to compromise balance control capabilities, thus increasing the probability of falling. Current research in robotic prostheses is exploring novel strategies to assess the risk of fall and, if required, enabl ...

LIPPINCOTT WILLIAMS & WILKINS2022

Intrinsically High Capacity of Animal Cells From a Symbiotic Cnidarian to Deal With Pro-Oxidative Conditions

Gaëlle Delphine Toullec

The cnidarian-dinoflagellate symbiosis is a mutualistic intracellular association based on the photosynthetic activity of the endosymbiont. This relationship involves significant constraints and requires co-evolution processes, such as an extensive capacit ...

FRONTIERS MEDIA SA2022

NanoSafe III: A User Friendly Safety Management System for Nanomaterials in Laboratories and Small Facilities

Thierry Meyer, Alke Fink, Anna Maria Novello, Elina Buitrago

Research in nanoscience continues to bring forward a steady stream of new nanomaterials and processes that are being developed and marketed. While scientific committees and expert groups deal with the harmonization of terminology and legal challenges, risk ...

2021

Semi-quantitative Model for Risk Assessment in University Laboratories

Thierry Meyer, Anastasia Jung

University chemical laboratories, contrary to common perception, are dangerous working environments. Unlike industry, where most processes are standardized, in academia, they are modified so frequently that in-depth and detailed risk assessment becomes unf ...

Springer, Cham2021

Limitations and Uncertainties of Acute Fish Toxicity Assessments Can Be Reduced Using Alternative Methods

Kristin Schirmer

Information about acute fish toxicity is routinely required in many jurisdictions for environmental risk assessment of chemicals. This information is typically obtained using a 96-hour juvenile fish test for lethality according to OECD test guideline (TG) ...

2021

Essays in Banking and Financial Regulation

Susanne Johanna Petronella Léonie Vissers

This thesis examines how banks choose their optimal capital structure and cash reserves in the presence of regulatory measures. The first chapter, titled Bank Capital Structure and Tail Risk, presents a bank capital structure model in which bank assets ...

EPFL2021

Risk-based methodology to assess bridge condition based on visual inspection

Eugen Brühwiler, Numa Joy Bertola

The visual inspection of existing infrastructure is a critical step for asset management, as the detection and quantification of damage must be useful to prioritise maintenance. In Switzerland, main inspections are made every five years for all road bridge ...

2021

Overcorrected Implants for Total Shoulder Arthroplasty

Yasmine Boulanaache

Glenohumeral osteoarthritis is a degenerative shoulder joint disease, which causes the breakdown of articular cartilage and bone. People affected by this disease suffer from severe pain and eventually reduced mobility and poor life quality. This disease is ...

EPFL2021

A risk-based multi-level stress test methodology: application to six critical non-nuclear infrastructures in Europe

Anton Schleiss, José Pedro Gamito de Saldanha Calado Matos, Daniela Rodrigues

Recent natural disasters that seriously affected critical infrastructure (CI) with significant socio-economic losses and impact revealed the need for the development of reliable methodologies for vulnerability and risk assessment. In this paper, a risk-bas ...

2020

Assessing Subaquatic Mass Movement Hazards: an Integrated Observational and Hydrodynamic Modelling Approach

Alfred Johny Wüest, Damien Bouffard, Nathalie Dubois, Carl Love Mikael Råman Vinnå

High-resolution lake and reservoir bathymetric surveys can pinpoint locations that may experience underwater landslides (subaquatic sedimentary mass movements). These can pose a risk to underwater and shoreline infrastructure. This paper outlines an approa ...

2020

Efficient management of nanomaterial hazards in a large number of research laboratories in an academic environment

Thierry Meyer, Amela Groso, Anna Maria Novello, Elina Buitrago

As the number of engineered nanomaterials (ENM) used in research increases with an incredible speed, health and safety specialists are continuously faced with the challenge of evaluating the risks involved with these materials. Nowadays there is not enough ...

2020

Impact of facade details on the reliability of performance-based decisions for early-stage neighborhood designs

Minu Agarwal

Neighborhood-scale projects often commence with the conceptualization of several massing-schemes as potential design solutions. There is growing interest in using building performance simulation (BPS) to evaluate and rank such conceptual stage schemes in o ...

EPFL2020

Innovative Techniques and Strategies for a Reliable High-Throughput Genotoxicity Assessment

Pauline Franz

Damage to DNA is a central mechanism to the initiation of carcinogenesis. As a consequence, precise DNA damage detection is essential for an effective risk assessment of xenobiotics and constitutes a powerful tool for human biomonitoring and early stage ca ...

AMER CHEMICAL SOC2020