Publications associées à Imaging and pattern projection through multicore fibers using the memory effect

Compact and effective photon-resolved image scanning microscope

Fluorescence confocal laser-scanning microscopy (LSM) is one of the most popular tools for life science research. This popularity is expected to grow thanks to single-photon array detectors tailored for LSM. These detectors offer unique single-photon spati ...

Spie-Soc Photo-Optical Instrumentation Engineers2024

Subsurface fluorescence time-of-flight imaging using a large-format single-photon avalanche diode sensor for tumor depth assessment

Claudio Bruschini, Edoardo Charbon, Arin Can Ülkü, Yichen Feng

Significance: Fluorescence guidance is used clinically by surgeons to visualize anatomical and/or physiological phenomena in the surgical field that are difficult or impossible to detect by the naked eye. Such phenomena include tissue perfusion or molecula ...

SPIE Society of Photo-optical Instrumentation Engineers2024

Live-cell imaging powered by computation

Suliana Manley, Florian Jug

The proliferation of microscopy methods for live-cell imaging offers many new possibilities for users but can also be challenging to navigate. The prevailing challenge in live-cell fluorescence microscopy is capturing intra-cellular dynamics while preservi ...

Nature Portfolio2024

Practical computational imaging by use of spatiotemporal light modulation: from simulations to applications in biological microscopy

François Thierry M Marelli

Optical microscopy is an essential tool for biologists, who are often faced with the need to overcome the spatial and temporal resolution limitations of their devices to capture finer details. As upgrading imaging hardware is expensive, computational metho ...

EPFL2023

Imaging system with silicon photomultipliers and method for operating thereof

Edoardo Charbon, Andrada Alexandra Muntean

The invention relates to an integrated imaging system comprising: - an array of analog photomultiplier elements - a plurality of submodules, each submodule having a number of the photomultiplier elements; - a plurality of time-to-digital converters each as ...

2023

Functional neuroimaging options for tinnitus

Patrick Karl Alois Neff

Background: The pathophysiology behind tinnitus is still not well understood. Different imaging methods help in the understanding of the complex relationships that lead to the perception of tinnitus.Objective: Herein, different functional imaging methods t ...

SPRINGER2023

Time-resolved imaging with SPAD detectors

Jiuxuan Zhao

With the capabilities such as single-photon detection, time stamping and high-speed acquisition, time-resolved imaging based on single-photon avalanche diode (SPAD) detectors has found significant applications across diverse domains, including but not limi ...

EPFL2023

Chemical Probe for Imaging of Polo-like Kinase 4 and Centrioles

Kai Johnsson, Luc Reymond, Pierre Gönczy, Aleksandar Salim, Georgios Hatzopoulos

Polo-like kinase (Plk4) is a serine/threonine-proteinkinase thatis essential for biogenesis of the centriole organelle and is enrichedat centrioles. Herein, we introduce Cen-TCO, a chemical probe basedon the Plk4 inhibitor centrinone, to image Plk4 and cen ...

AMER CHEMICAL SOC2023

Pixel super-resolution with spatially entangled photons

Edoardo Charbon, Jiuxuan Zhao

Pixelation is common in quantum imaging systems and limit the image spatial resolution. Here, the authors introduce a pixel super-resolution approach based on measuring the full spatially-resolved joint probability distribution of spatially-entangled photo ...

Nature Portfolio2022

Medipix4, a high granularity four sides buttable pixel readout chip for high resolution spectroscopic X-ray imaging at rates compatible with medical CT scans

Viros Sriskaran

Medipix4 is the latest member in the Medipix/Timepix family of pixel detector chips aimed at high rate spectroscopic X-ray imaging using high-Z materials. The chip address the limitations of conventional hybrid pixel detectors for X-ray imaging. Its predec ...

EPFL2022

Amplitude and phase reconstruction for Low-Energy Electron Holography of individual proteins

Hannah Julia Ochner

Single-molecule imaging methods are of importance in structural biology, and specifically in the imaging of proteins, since they can elucidate conformational variability and structural changes that might be lost in imaging methods relying on averaging proc ...

EPFL2022

Direct time-of-flight SPAD image sensors for light detection and ranging

Preethi Padmanabhan

Depth sensing is an increasingly important feature in many applications of consumer, automotive, augmented/virtual reality (AR-VR), space and bio-medical imaging. Long range, high depth resolution, high spatial resolution, and high frame rates are often co ...

EPFL2021

Large-Format Time-Gated SPAD Cameras for Real-Time Phasor-Based FLIM

Arin Can Ülkü

Fluorescence lifetime imaging microscopy (FLIM) is an imaging modality often used to monitor biochemical properties of a cell or a tissue. In addition to conventional fluorescence microscopy features, such as selective labeling and non-invasiveness, FLIM e ...

EPFL2021

Megapixel SPAD cameras for time-resolved applications

Kazuhiro Morimoto

Progress in optics technology has enriched our daily lives in many ways. Various types of single-photon detector technologies have emerged in the last century. Among these, single-photon avalanche diode (SPAD) technology outperforms other detectors for its ...

EPFL2020

Towards quantum 3D imaging devices

Claudio Bruschini, Edoardo Charbon, Samuel Burri, Arin Can Ülkü, Paul Mos, Michael Alan Wayne

We introduce a new generation of 3D imaging devices based on quantum plenoptic imaging. Position-momentum entanglement and photon number correlations are exploited to provide a scan-free 3D image after post-processing of the collected light intensity signa ...

2021

High-Resolution Multi-Spectral Imaging With Diffractive Lenses and Learned Reconstruction

Oguzhan Fatih Kar, Can Deniz Bezek

Spectral imaging is a fundamental diagnostic technique with widespread application. Conventional spectral imaging approaches have intrinsic limitations on spatial and spectral resolutions due to the physical components they rely on. To overcome these physi ...

IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC2021

Systematic Tuning of Rhodamine Spirocyclization for Super-resolution Microscopy

Kai Johnsson, Lu Wang

Rhodamines are the most important class of fluorophores for applications in live-cell fluorescence microscopy. This is mainly because rhodamines exist in a dynamic equilibrium between a fluorescent zwitterion and a nonfluorescent but cell-permeable spirocy ...

AMER CHEMICAL SOC2021

Single-molecule localization microscopy

Suliana Manley, Juliette Griffie

Single-molecule localization microscopy (SMLM) describes a family of powerful imaging techniques that dramatically improve spatial resolution over standard, diffraction-limited microscopy techniques and can image biological structures at the molecular scal ...

SPRINGERNATURE2021

Simulated Half-Fourier Acquisitions Single-shot Turbo Spin Echo (HASTE) of the Fetal Brain: Application to Super-Resolution Reconstruction

Meritxell Bach Cuadra, Patric Hagmann, Reto Meuli, Sébastien Tourbier, Tobias Kober, Hamza Kebiri, Tom Hilbert, Thomas Yu

Accurate characterization of in utero human brain maturation is critical as it involves complex interconnected structural and functional processes that may influence health later in life. Magnetic resonance imaging is a powerful tool complementary to the u ...

SPRINGER INTERNATIONAL PUBLISHING AG2021

Biophysical applications of correlative scanning probe and super-resolution microscopy

Vytautas Navikas

Imaging live cells in their native environment is crucial for the understanding of complex biological phenomena. Modern optical microscopy methods such as fluorescence super-resolution microscopy are increasingly combined with complementary, label-free tec ...

EPFL2021