Publications associées à Modelling cholera epidemics: the role of waterways, human mobility and sanitation

Genome sequences of Vibrio cholerae strains isolated in the DRC between 2009 and 2012

Melanie Blokesch, Sandrine Stutzmann, Natalia Carolina Drebes Dorr, Alexandre Lemopoulos

Vibrio cholerae has caused seven cholera pandemics in the past two centuries. The seventh and ongoing pandemic has been particularly severe on the African continent. Here, we report long read-based genome sequences of six V. cholerae strains isolated in th ...

2024

Dangerous acquaintances: the interplay between type IV pili and the type VI secretion system during Vibrio cholerae's environmental lifestyle

Simon Bernhard Otto

Cholera, caused by the bacterium Vibrio cholerae, has affected humanity throughout history and still impacts millions of people every year. Apart from being a human pathogen, V. cholerae is a common member of the aquatic environment. Due to this natural re ...

EPFL2024

Sporadic type VI secretion in seventh pandemic Vibrio cholerae

Melanie Blokesch, Sandrine Stutzmann, Lisa Christina Metzger, Natalia Carolina Drebes Dorr, Sandrine Natacha Isaac, Nicolas René Chiaruttini, Alexis Joseph Proutière, Loriane Bader

Vibrio cholerae is a pathogen that causes disease in millions of people every year by colonizing the small intestine and then secreting the potent cholera toxin. How the pathogen overcomes the colonization barrier created by the host’s natural microbiota i ...

2023

Non-volatile data storage medium and system

Martin Vetterli, Yves Bellouard, Ruben Ricca

A data storage medium (2) comprising a stacked plurality of layers (9), each layer composed of a layer material selected from a group comprising at least two different dielectric materials, adjacent layers being formed of different materials, and at least ...

2023

A hybrid Selective Laser Sintering based process for the additive manufacturing of architectured composites

Erwan Philippe Guenier

Additive Manufacturing also commonly referred as 3D printing has been given a lot of interest lately. Market is growing exponentially and the aim for obtaining more complex and ready-to use parts is emerging. All the 3D printing processes consist in buildi ...

EPFL2023

Epidemicity of cholera spread and the fate of infection control measures

Andrea Rinaldo, Lorenzo Mari, Joseph Chadi Benoit Lemaitre, Marino Gatto, Damiano Pasetto, Cristiano Trevisin

The fate of ongoing infectious disease outbreaks is predicted through reproduction numbers, defining the long-term establishment of the infection, and epidemicity indices, tackling the reactivity of the infectious pool to new contagions. Prognostic metrics ...

2022

Hardware and Software Support for RPC-Centric Server Architecture

Mark Johnathon Sutherland

Online services have become ubiquitous in technological society, the global demand for which has driven enterprises to construct gigantic datacenters that run their software. Such facilities have also recently become a substrate for third-party organizatio ...

EPFL2022

Superior visible light-mediated catalytic activity of a novel N-doped, Fe3O4-incorporating MgO nanosheet in presence of PMS: Imidacloprid degradation and implications on simultaneous bacterial inactivation

Stefanos Giannakis, Jérémie Decker

Impressive Imidacloprid (IMD) degradation and bacterial inactivation were attained through the photocatalytic activation of peroxymonosulfate (PMS) via a novel, N-doped MgO@Fe3O4, under visible light. After complete characterization (XPS, XRD, FT-IR, FE-SE ...

ELSEVIER2022

Modeling infectious disease dynamics towards informed public health interventions, with applications on COVID-19 and cholera

Joseph Chadi Benoit Lemaitre

Emerging and existing infectious diseases pose a constant threat to individuals and communities across the world. In many cases, the burden of these diseases is preventable through public health interventions. However, taking the right decisions and design ...

EPFL2021

The molecular treasure box of environmental Vibrio cholerae strains

Natalia Carolina Drebes Dorr

Cholera pandemics have been affecting humankind for centuries and are still considered a major public health problem, especially in regions around the world with poor access to clean water and sanitation. Cholera pandemics are caused by a specific lineage ...

EPFL2021

Epidemic mitigation by statistical inference from contact tracing data

Maria Refinetti, Giovanni Catania, Florent Gérard Krzakala, Lenka Zdeborová, Indaco Biazzo

Contact tracing is an essential tool to mitigate the impact of a pandemic, such as the COVID-19 pandemic. In order to achieve efficient and scalable contact tracing in real time, digital devices can play an important role. While a lot of attention has been ...

National Academy of Sciences2021

Transparent composite nano-fibre based multi-layer textile

Klaus Benedikt Schönenberger, Thierry Pelet

A composite multi-layer textile (1), comprising at least one nanofibre layer (11) with nanofibres with diameters below 100nm and one support layer (12) with microfibres with diameters below three microns, wherein the layers (11, 12) were produced by electr ...

2021

Private and Secure Distributed Learning

Georgios Damaskinos

The ever-growing number of edge devices (e.g., smartphones) and the exploding volume of sensitive data they produce, call for distributed machine learning techniques that are privacy-preserving. Given the increasing computing capabilities of modern edge de ...

EPFL2020

Annealing and Replica-Symmetry in Deep Boltzmann Machines

Emanuele Mingione, Diego Alberici

In this paper we study the properties of the quenched pressure of a multi-layer spin-glass model (a deep Boltzmann Machine in artificial intelligence jargon) whose pairwise interactions are allowed between spins lying in adjacent layers and not inside the ...

SPRINGER2020

Rainfall as a driver of epidemic cholera: Comparative model assessments of the effect of intra-seasonal precipitation events

Andrea Rinaldo, Francisco Javier Perez Saez, Joseph Chadi Benoit Lemaitre, Carla Sciarra, Damiano Pasetto

The correlation between cholera epidemics and climatic drivers, in particular seasonal tropical rainfall, has been studied in a variety of contexts owing to its documented relevance. Several mechanistic models of cholera transmission have included rainfall ...

2019

Reliable and Robust Cyber-Physical Systems for Real-Time Control of Electric Grids

Wajeb Saab

Real-time control of electric grids is a novel approach to handling the increasing penetration of distributed and volatile energy generation brought about by renewables. Such control occurs in cyber-physical systems (CPSs), in which software agents maintai ...

EPFL2019

Assessing the interplay between human mobility and mosquito borne diseases in urban environments

Emanuele Massaro

Urbanization drives the epidemiology of infectious diseases to many threats and new challenges. In this research, we study the interplay between human mobility and dengue outbreaks in the complex urban environment of the city-state of Singapore. We integra ...

Springer Nature2019

Health risks for sanitation service workers along a container-based urine collection system and resource recovery value chain

Tamar Kohn, Simon Schindelholz, Timothy R. Julian

Container-based sanitation (CBS) within a comprehensive service system value chain offers a low-cost sanitation option with potential for revenue generation, but may increase microbial health risks to sanitation service workers. This study assessed occupat ...

2019

Field-effect transistor device or sensor for sensing ions, molecules or biomarkers in a fluid

Mihai Adrian Ionescu, Erick Antonio Garcia Cordero, Junrui Zhang, Francesco Bellando

The present disclosure concerns a Field-Effect Transistor device or sensor comprising at least one drain region, at least one source region, at least a channel region, at least a first gate connected to the channel region, at least one stack comprising at ...

2019

Single crystalline diamond diffractive optical elements and method of fabricating the same

Niels Quack, Marcell Kristof Kiss, Teodoro Graziosi

The present invention concerns a single crystalline diamond optical element production method. The method includes the steps of: ‐ providing a single crystalline diamond substrate or layer; ‐ applying a mask layer to the single crystalline diamond substrat ...

2019