Multicontrats MRI Improved the Clinico-Radiological Correlation in Early Multiple Sclerosis Patients with Minor Deficits

Conventional magnetic resonance imaging (MRI) of patients with multiple sclerosis provides only limited insights into the nature of brain tissue damage with modest clinical-radiological correlations. In this study, quantitative and semi-quantitative MRI techniques (T1, T2, T2*, MTR) were applied to study the potential of the MRI-accessible microstructural information to predict cognitive and motor scores in patients. A multiparametric analysis of whole brain abnormalities showed that MRI measures of microstructural alterations lead to significant improvement in clinical-radiological correlations even in the presence of minor functional deficits.