Publications associées à A digital reconstruction of the 1630–1631 large plague outbreak in Venice

Single nucleotide polymorphism determines constitutive versus inducible type VI secretion in Vibrio cholerae

Melanie Blokesch, Sandrine Stutzmann, Milena Jadwiga Jaskolska, Natalia Carolina Drebes Dorr, Alexis Joseph Proutière, Loriane Bader

Vibrio cholerae is a well-studied human pathogen that is also a common inhabitant of marine habitats. In both environments, the bacterium is subject to interbacterial competition. A molecular nanomachine that is often involved in such competitive behavior ...

2022

How to detect and reduce potential sources of biases in studies of SARS-CoV-2 and COVID-19

Mats Julius Stensrud

In response to the coronavirus disease (COVID-19) pandemic, public health scientists have produced a large and rapidly expanding body of literature that aims to answer critical questions, such as the proportion of the population in a geographic area that h ...

2021

A Machine-Generated View of the Role of Blood Glucose Levels in the Severity of COVID-19

Henry Markram, Daniel Keller, Emmanuelle Logette, Francesco Casalegno, Jay Coggan, Cyrille Pierre Henri Favreau, Mohameth François Sy, Samuel Claude Kerrien, Anna-Kristin Kaufmann, Pierre-Alexandre Fonta, Enrico Scantamburlo, Marine Laure Bertschy

SARS-CoV-2 started spreading toward the end of 2019 causing COVID-19, a disease that reached pandemic proportions among the human population within months. The reasons for the spectrum of differences in the severity of the disease across the population, an ...

FRONTIERS MEDIA SA2021

Contact networks across ages: computational analysis of epidemiological dynamics

Gianrocco Lazzari

For decades mathematical modeling in epidemiology has helped understanding the dynamics of infectious diseases, as well as describe possible intervention scenarios to prevent and control them. However, such models were relying on several assumptions, such ...

EPFL2020

Virucidal nanomaterials against influenza

Özgün Kocabiyik

Influenza affects millions of people in all parts of the world. The fact that influenza virus can spread through air increases the chance of influenza outbreaks. There are 3 to 5 million severe cases of influenza resulting in 290,000 to 650,000 deaths ever ...

EPFL2019

Genetic characterization of an adapted pandemic 2009 H1N1 influenza virus that reveals improved replication rates in human lung epithelial cells

Christian Sieben

The 2009 influenza pandemic originated from a swine-origin H1N1 virus, which, although less pathogenic than anticipated, may acquire additional virulence-associated mutations in the future. To estimate the potential risk, we sequentially passaged the isola ...

Academic Press Inc Elsevier Science2016

FluReF, an automated flu virus reassortment finder based on phylogenetic trees

Bernard Moret, Alisa Yurovsky

Background: Reassortments are events in the evolution of the genome of influenza (flu), whereby segments of the genome are exchanged between different strains. As reassortments have been implicated in major human pandemics of the last century, their identi ...

IEEE Press2010