Publications associées à Detecting trends and further development potential of contemporary façade design for workspaces

Embodied Carbon Premium for Cantilevers

David Michael Volpe Ruggiero, Paola Costanza Miglietta

This study addresses the critical need for sustainable architectural designs within the context of climate change and the significant role the built environment plays in greenhouse gas emissions. The focus of this paper is on understanding the influence of ...

2024

High throughput wide field second harmonic imaging of giant unilamellar vesicles

Sylvie Roke, Pierre-Marc Jean Marie Dansette, Maksim Eremchev, David Roesel

Cell-sized giant unilamellar vesicles (GUVs) are an ideal tool for understanding lipid membrane structure and properties. Label-free spatiotemporal images of their membrane potential and structure would greatly aid the quantitative understanding of membran ...

AIP Publishing2023

Risk of incorrect choices due to uncertainty in BPS evaluations of conceptual-stage neighbourhood-scale building designs

Marilyne Andersen, Luisa Pastore, Minu Agarwal

At the conceptual stage, building performance simulation (BPS) based evaluations are being increasingly used for tasks such as ranking of competing massing design proposals. However, such conceptual stage evaluations suffer from information deficiency in b ...

2023

Effects of thermal, mechanical, and electrostatic perturbations on lipid membrane hydration investigated by second harmonic imaging

Seonwoo Lee

Hydrated lipid bilayer membranes are crucial components of cells and organelles, serving as the outer boundary that separates the cellular components from the extracellular environment. Lipid membranes regulate their structures and functions by dynamically ...

EPFL2023

Cell Type-Specific Membrane Potential Changes in Dorsolateral Striatum Accompanying Reward-Based Sensorimotor Learning

Carl Petersen, Sylvain Crochet, Tanya C Sippy

The striatum integrates sensorimotor and motivational signals, likely playing a key role in reward-based learning of goal-directed behavior. However, cell type-specific mechanisms underlying reinforcement learning remain to be precisely determined. Here, w ...

OXFORD UNIV PRESS2021

The role of medial amygdala inhibitory neurons in regulating social behavior

Aiste Baleisyte

Aggression is an evolutionary conserved social behavior that is necessary for an animalÂŽs survival. The neural substrates coordinating aggression are known to exist in the amygdala and the hypothalamus. While the medial amygdala (MeA) and the ventrolatera ...

EPFL2021

Planning for a Changing Climate without Accurate Predictions

Parag Rastogi, Mohammad Emtiyaz Khan

Simulation is an informative tool to plan the design and renovation of engineering systems, but its use requires accurate inputs from the users. Inputs such as the unknown future operating conditions might be expected in a system’s lifetime, e.g., the futu ...

Taylor & Francis Group2021

Transient domains of ordered water induced by divalent ions lead to lipid membrane curvature fluctuations

Sylvie Roke, Orly Bagunu Tarun, Halil Ibrahim Okur

Cations influence the electrostatic, chemical and mechanical properties of lipid bilayers. Here, label-free second harmonic microscopy shows that cation-induced transient ordering of water also plays a role in driving membrane curvature fluctuations, linki ...

NATURE PUBLISHING GROUP2020

How to polarise an interface with ions: the discrete Helmholtz model

Hubert Girault, Astrid Johana Olaya Avendano, Grégoire Clément Gschwend

The distribution of electrolytes in an electric field usually relies on theories based on the Poisson-Boltzmann formalism. These models predict that, in the case of a metallic electrode, ionic charges screen the electrode potential, leading to concentratio ...

2020

Discrete Helmholtz charge distribution at liquid-liquid interfaces: Electrocapillarity, capacitance and non-linear spectroscopy studies

Hubert Girault, Grégoire Clément Gschwend

The structure of the polarised interface between two immiscible electrolyte solutions (ITIES) has usually been deduced from electrocapillarity and capacitance measurements. However, these two methods only offer an indirect access to the surface change dens ...

ELSEVIER SCIENCE SA2020

Surveying the environmental life-cycle performance assessments: Practice and context at early building design stages

Emmanuel Rey, Marilyne Andersen, Thomas Bernard Paul Jusselme

The international greenhouse gas agreements call for mitigations in the building industry. Thus, the number of scientific publications about life-cycle performance assessment (LCPA) follows an exponential trend since the 2000s. However, previous surveys hi ...

2020

Influence of cracking and rough surface properties on the transfer of forces in cracked concrete

Aurelio Muttoni, Miguel Fernández Ruiz, Max Tirassa

Aggregate interlocking is acknowledged as one of the most significant actions transferring shear forces in cracked concrete structures and has been investigated for several decades. Despite the many experimental programmes and previous efforts to develop m ...

2020

Metabolomics reveals tepotinib‐related mitochondrial dysfunction in MET activating mutations‐driven models

Katarzyna Pierzchala

Genetic aberrations in the hepatocyte growth factor receptor tyrosine kinase MET induce oncogenic addiction in various types of human cancers, advocating MET as a viable anticancer target. Here, we report that MET signaling plays an important role in confe ...

2019

In Silico Voltage-Sensitive Dye Imaging: A Model-Based Approach for Bridging Scales of Cortical Activity

Taylor Howard Newton

An understanding of how microscale voltage fluctuations interact to shape mesoscale cortical information processing is lacking. Voltage-sensitive dye imaging (VSDI) is a powerful technique for interrogating membrane potential dynamics in assemblies of cort ...

EPFL2019

Dynamic Imaging of Lipid Membranes by Means of Water

Orly Bagunu Tarun

Lipid membranes are self-assembled structures whose composition determines the properties of membranes of cells and organelles. The molecular level understanding of lipid membranes is based on spectroscopy and MD simulations of lipid monolayer systems. As ...

EPFL2019

A digital workflow to quantify regenerative urban design in the context of a changing climate

Parag Rastogi, Pietro Florio, Emanuele Naboni

The regenerative approach to design goes beyond limiting the environmental impact of the built environment and towards the enrichment of the ecosystem, adaptation to climate change, and the improvement of human health. This concept is being applied to buil ...

2019

Measurement of Mitochondrial Mass and Membrane Potential in Hematopoietic Stem Cells and T-cells by Flow Cytometry

Nicola Vannini, Mukul Girotra, Olaia Maria Naveiras Torres-Quiroga, George Coukos, Alexandre Harari

A fine balance of quiescence, self-renewal, and differentiation is key to preserve the hematopoietic stem cell (HSC) pool and maintain lifelong production of all mature blood cells. In recent years cellular metabolism has emerged as a crucial regulator of ...

2019

How building energy models take the local climate into account in an urban context – A review

Dasaraden Mauree

The urban context is often simplified or neglected in Building Energy Models (BEMs) due to the difficulties of taking accurately into account all the heat fluxes emanating from the environment. Oversimplifying the urban context can impact the accuracy of t ...

2019

Membrane water for probing neuronal membrane potentials and ionic fluxes at the single cell level

Pierre Magistretti, Pascal Jourdain, Sylvie Roke, Marie Eve Pascale Didier, Orly Bagunu Tarun

Neurons communicate through electrochemical signaling within a complex network. These signals are composed of changes in membrane potentials and are traditionally measured with the aid of (toxic) fluorescent labels or invasive electrical probes. Here, we d ...

Nature Publishing Group2018

Label-free and charge-sensitive dynamic imaging of lipid membrane hydration on millisecond time scales

Sylvie Roke, Orly Bagunu Tarun

Biological membranes are highly dynamic and complex lipid bilayers, responsible for the fate of living cells. To achieve this function, the hydrating environment is crucial. However, membrane imaging typically neglects water, focusing on the insertion of p ...

2018