Publications associées à Decoding bladder state from pudendal intraneural signals in pigs

System for micturition control in a mammal with bladder disfunction

Grégoire Courtine, Jocelyne Bloch, Jordan Squair, Loïs Thomas Romain Mahe

The present invention relates to a neuromodulation/neurostimulation system (10) for stimulating at least one neuronal circuitry responsible for micturition control in a mammal with bladder disfunction, especially for bladder relaxation and/or for bladder v ...

2024

An artificial urinary sphincter based on dielectric elastomer technology

Yves Perriard, Yoan René Cyrille Civet, Stefania Maria Aliki Konstantinidi, Quentin Philippe Mario De Menech, Sloan Zammouri, Amine Benouhiba

Urinary incontinence (UI) is prevalent and distressing medical condition affecting millions of patients worldwide. Current treatment options for severe cases often involve surgical intervention, such as the implantation of an artificial urinary sphincter ( ...

Society of Photo-Optical Instrumentation Engineers (SPIE)2024

Mechanical Characterisation of Porcine Urethra: Non Linear Constitutive Models and Experimental Approach

Yves Perriard, Yoan René Cyrille Civet, Thomas Guillaume Martinez, Stefania Maria Aliki Konstantinidi, Quentin Philippe Mario De Menech, Amine Benouhiba

Low urinary tract dysfunctions and symptoms (LUTS) and Urinary incontinence (UI) in particular is a medical condition that affects millions of people worldwide. One of the most promising long term treatments for this condition is the use of an artificial u ...

IEEE2023

Identification of genes required for host-cell adhesion and antibiotic persistence of uropathogenic Escherichia coli via high-content screening

Thomas Marie Simonet

Uropathogenic Escherichia coli (UPEC) are the most common bacterial pathogens causing urinary tract infections (UTIs). Driven by the development of antibiotic resistant UPEC strains, UTIs have become a major public health issue and generate substantial hea ...

EPFL2022

Hardware-Friendly Random Forest Classification of iEEG Signals for Implantable Seizure Detection

Alexandre Schmid, Keyvan Farhang Razi

Early and accurate detection of epileptic seizures is an extremely important therapeutic goal due to the severity of complications it can prevent. To this end, a low-power machine learning-based seizure detection implemented on an FPGA is proposed in this ...

IEEE2022

Microtissue models for studying the dynamics of host-pathogen interactions in the urinary bladder

Kunal Sharma

Urinary tract infections (UTIs) are amongst the most common bacterial infections and are the second-most frequent reason for antibiotic prescriptions. Moreover, in about 25% of all treated cases, recurrence of infection occurs. Uropathogenic Escherichia co ...

EPFL2021

Dynamic persistence of UPEC intracellular bacterial communities in a human bladder-chip model of urinary tract infection

Graham Knott, John McKinney, Neeraj Dhar, François Signorino-Gelo, Kunal Sharma, Thomas Marie Simonet, Vivek Vijay Thacker

Uropathogenic Escherichia coli (UPEC) proliferate within superficial bladder umbrella cells to form intracellular bacterial communities (IBCs) during early stages of urinary tract infections. However, the dynamic responses of IBCs to host stresses and anti ...

2021

Neural circuits of idiopathic Normal Pressure Hydrocephalus: A perspective review of brain connectivity and symptoms meta-analysis

Dimitri Nestor Alice Van De Ville, Alessandra Griffa

Idiopathic normal pressure hydrocephalus (iNPH) is a prevalent reversible neurological disorder characterized by impaired locomotion, cognition and urinary control with ventriculomegaly. Symptoms can be relieved with cerebrospinal fluid drainage, which mak ...

PERGAMON-ELSEVIER SCIENCE LTD2020

Biodegradation and Antimicrobial Properties of Zinc Oxide-Polymer Composite Materials for Urinary Stent Applications

Lorenzo Lucherini

Research advancements in the field of urinary stents have mainly been in the selection of materials and coatings to address commonly faced problems of encrustation and bacterial adhesion. In this study, polylactic acid (PLA) and polypropylene (PP) were eva ...

2020

Development of a biologically inspired in-vitro platform for long-term assessment of commercial and innovative ureteral stents

Yves Perriard, Yoan René Cyrille Civet, Francesco Clavica

Ureteral stents are small flexible tubes which are clinically used to restore the urine drainage in presence of obstructions of the ureteral lumen such as tumours, kidney/ureteral stones. The lifetime risk of developing urinary stones is about 20% in men a ...

2019

Impedance pumping as a non-invasive treatment for underactive bladder? An ex-vivo proof-of-concept-study in porcine bladders

Yves Perriard, Yoan René Cyrille Civet, Francesco Clavica

In patients suffering from underactive bladder (UAB), the contraction of the detrusor muscle has insufficient strength or duration to ensure efficient bladder emptying. Although catheterisation is currently the most effective method to empty the bladder, i ...

2019

Urine-Contactless Device to Empty Bladders: an Ex-Vivo Proof-of-Concept Study in Porcine Bladders

Yves Perriard, Yoan René Cyrille Civet, Francesco Clavica

Current treatments for underactive bladder (UAB) have negative side effects, such as urinary tract infections, mainly because devices used for bladder emptying are in direct contact with urine (e.g. permanent or intermittent catheterisation). Moreover, mos ...

Wiley2019

Bladder Cancer Photodynamic Therapeutic Agent with Off-On Magnetic Resonance Imaging Enhancement

Jean-Claude Bünzli, Chen Xie

Acting as an extracellular matrix protein receptor, alpha(v)beta(3) integrin becomes an appealing target for photodynamic therapy of bladder cancer. Here, specific alpha(v)beta(3)-integrin-targeting porphyrinato-gadolinium complexes (Gd-PEG-R-n) are demons ...

WILEY2019

Sensory feedback restoration in leg amputees improves walking speed, metabolic cost and phantom pain

Silvestro Micera, Stanisa Raspopovic, Francesco Maria Petrini, Giacomo Valle, Federica Barberi, Dario Bortolotti

Conventional leg prostheses do not convey sensory information about motion or interaction with the ground to aboveknee amputees, thereby reducing confidence and walking speed in the users that is associated with high mental and physical fatigue(1-4). The l ...

2019

Neuromodulation in the restoration of function after spinal cord injury

Nicholas David James

Neuromodulation, the use of electrical interfaces to alter neuronal activity, has been successful as a treatment approach in several neurological disorders, including deep brain stimulation for Parkinson's disease and epidural spinal stimulation for chroni ...

2018

Novel Concept Enabling an Old Idea: A Flexible Electrode Array to Treat Neurogenic Erectile Dysfunction

Nikolaos Stergiopoulos, Mikaël Nils Sturny, Rodrigo Araujo Fraga Da Silva

Introduction: Many studies have shown that electrostimulation of the cavernosal nerve can induce and maintain penile erection. Based on these discoveries, neurostimulation to activate the erectile response has been considered a potential solution to treat ...

ELSEVIER SCI LTD2018

Brain-actuated gait trainer with visual and proprioceptive feedback

Mohamed Bouri, Ricardo Andres Chavarriaga Lozano, José del Rocio Millán Ruiz, Kyuhwa Lee, Dong Liu

Objective. Brain-machine interfaces (BMIs) have been proposed in closed-loop applications for neuromodulation and neurorehabilitation. This study describes the impact of different feedback modalities on the performance of an EEG-based BMI that decodes moto ...

Institute of Physics2017

Microdevices for Locomotion in Complex Biological Fluids

Tian Qiu

Locomotion is an essential feature for survival of many organisms, and it is also a technical requirement for untethered biomedical microdevices to operate inside the human body for targeted drug delivery and minimally invasive surgery. The overall goal of ...

EPFL2016

IGF-1-containing multi-layered collagen-fibrin hybrid scaffolds for bladder tissue engineering

Jeffrey Alan Hubbell, Peter Frey, Priscilla Suhasna Maithili Briquez, Hans Mattias Larsson, Elif Vardar, Kalitha Pinnagoda

Clinical success of bladder reconstructive procedures could be promoted by the availability of functional biomaterials. In this study, we have developed a multi-layered scaffold consisting of a bioactive fibrin layer laminated between two collagen sheets a ...

Elsevier Sci Ltd2016

Brain-Controlled Devices: The Perception-Action Closed Loop

José del Rocio Millán Ruiz

Future neuroprosthetics will be tightly coupled with the user in such a way that the resulting system can replace and restore impaired upper limb functions because controlled by the same neural signals than their natural counterparts. However, robust and n ...

Ieee2016