Publications associées à Hexachlorobenzene exerts genotoxic effects in a humpback whale cell line under stable exposure conditions

The Bioaccumulation of Ionizable Organic Compounds in Fish Cell Lines

Bioaccumulation is defined as the enrichment of a compound in an organism relative to the surrounding water or its food, and is an important endpoint in chemical risk assessment. Under laboratory conditions, bioaccumulation is measured as bioconcentration ...

EPFL2023

Evaluation of tire tread particle toxicity to fish using rainbow trout cell lines

Florian Frédéric Vincent Breider, Kristin Schirmer, Benoît Jean Dominique Ferrari, Gabrielle Léger, Thibault Béranger Masset

Tire and road wear particles (TRWP) resulting from tire abrasion while driving raise concerns due to their potential contribution to aquatic toxicity. Our study aimed to assess cryogenically milled tire tread (CMTT) particle toxicity, used as a proxy for T ...

2023

A Whale's Tail - Finding the Right Whale in an Uncertain World

Devis Tuia

Explainable machine learning and uncertainty quantification have emerged as promising approaches to check the suitability and understand the decision process of a data-driven model, to learn new insights from data, but also to get more information about th ...

SPRINGER INTERNATIONAL PUBLISHING AG2022

In vitro acute toxicity assessment of tire tread particles using rainbow trout cell lines of gill and intestine

Florian Frédéric Vincent Breider, Kristin Schirmer, Benoît Jean Dominique Ferrari, Thibault Béranger Masset

Tire and road wear particles (TRWP) are generated by the abrasion of tires while driving, and recent questions were raised in regards to their potential contribution to microplastics released into the aquatic environment and their potential toxicological i ...

2021

Biotin-NeutrAvidin Mediated Immobilization of Polymer Micro- and Nanoparticles on T Lymphocytes

Harm-Anton Klok, Olivier Burri, Maxime Ayer, Arne Seitz, Romain Guiet

Cells are powerful carriers that can help to improve the delivery of nanomedicines. One approach to use cells as carriers is to immobilize the nanoparticulate cargo on the cell surface. While a plethora of chemical conjugation strategies are available to b ...

2021

The pro-apoptotic properties of a phytonutrient rich infusion of A. cherimola leaf extract on AML cells

Laure Menin, Natalia Gasilova, Rita Sarkis, Maria Younes

Annonaceae family has broad uses in herbal medicine for treatment of several diseases, whether through seeds' or leaves' extracts. The present study investigates the antiproliferative and antitumor activity of Annona cherimola aqueous leaf (AAL) extract/in ...

2021

Expression of E-Cadherin in Epithelial Cancer Cells Increases Cell Motility and Directionality through the Localization of ZO-1 during Collective Cell Migration

Hwanseok Jang

Collective cell migration of epithelial tumor cells is one of the important factors for elucidating cancer metastasis and developing novel drugs for cancer treatment. Especially, new roles of E-cadherin in cancer migration and metastasis, beyond the epithe ...

MDPI2021

Malva pseudolavatera Leaf Extract Promotes ROS Induction Leading to Apoptosis in Acute Myeloid Leukemia Cells In Vitro

Rita Sarkis

Malva pseudolavatera Webb & Berthel. is a plant from the Malvaceae family that has long been included in the human diet due to its various curative effects. Many plant leaf extracts from the various species of Malva genus have been reported to possess anti ...

MDPI2020

BAF restricts cGAS on nuclear DNA to prevent innate immune activation

Beat Fierz, Andrea Ablasser, Mahmut Selman Sakar, Murat Kaynak, Baptiste Claude André Guey, Alexiane Clara Decout, Marilena Wischnewski, Kristina Makasheva

The appearance of DNA in the cytosol is perceived as a danger signal that stimulates potent immune responses through cyclic guanosine monophosphate–adenosine monophosphate synthase (cGAS). How cells regulate the activity of cGAS toward self-DNA and guard a ...

American Association for the Advancement of Science2020

Modeling metabolic and signaling pathways in cancer cells

Maria Masid Barcon

Cancer is a leading cause of death in the world, and the mechanisms that underlie this disease are still not completely understood. As cancer develops and progresses, cells undergo a diversity of mutations that sustain their rapid proliferation and the eva ...

EPFL2020

A fish intestinal barrier model to assess the interaction with chemicals in vitro

Hannah Inka Schug

The intestinal epithelium acts as vital gate keeper between the fish and its surrounding environment. A single layer of connected epithelial cells forms a selective barrier, which, among other essential functions, is important for nutrient uptake and defen ...

EPFL2019

Decellularised tissues obtained by a CO2-philic detergent and supercritical CO2

Dominique Pioletti, Pierre-Etienne Bourban, Nathalie Hirt-Burri, Matteo Gregorio Modesto Marascio, Jens Antons, Pierre-Arnaud Aeberhard, Giulia Weissenberger

Tissue decellularisation has gained much attention in regenerative medicine as an alternative to synthetic materials. In decellularised tissues, biological cues can be maintained and provide cellular environments still unmet by synthetic materials. Supercr ...

2018

Development of 3,5-Dinitrobenzylsulfanyl-1,3,4-oxadiazoles and Thiadiazoles as Selective Antitubercular Agents Active Against Replicating and Nonreplicating Mycobacterium tuberculosis

Stewart Cole, Edina Rita Székely, Anthony Vocat

Herein, we report the discovery and structure activity relationships of 5-substituted-2-[(3,5-dinitrobenzyl)-sulfanyl]-1,3,4-oxadiazoles and 1,3,4-thiadiazoles as a new class of antituberculosis agents. The majority of these compounds exhibited outstanding ...

American Chemical Society2016

Interaction of Silver Nanoparticles (AgNP) with Rainbow Trout Gill Cell Lines

Yang Yue

Owing to their unique antimicrobial properties, silver nanoparticles (AgNP) are among the most widely used engineered nanoparticles in a variety of consumer products and medical applications. Their resulting release into the aquatic environment raises conc ...

EPFL2015

The chromatin remodeller Chd7 and the calcium ATPase Serca2 - adding new facets to the role of Notch in Hematopoiesis and T-ALL

Monique Coersmeyer

Project I: Chd7 Deficiency does not affect N1-driven T-ALL Induction and Maintenance nor impair Hematopoiesis Notch1 has been shown to be a key driver in pediatric T-cell acute lymphobastic leukemia (T-ALL). Previous work in the lab identified the chromati ...

EPFL2015

Cellular uptake and biocompatibility of bismuth ferrite harmonic advanced nanoparticles

Daniel Rytz, Jean-Pierre Wolf, Sandrine Gerber, Luigi Bonacina, Stephanie Hwu, Solène Marcelle Françoise Marie Passemard, Davide Städler

Bismuth Ferrite (BFO) nanoparticles (BFO-NP) display interesting optical (nonlinear response) and magnetic properties which make them amenable for bio-oriented diagnostic applications as intra- and extra membrane contrast agents. Due to the relatively rece ...

Elsevier2015

Systems Toxicology Approach to Understand the Kinetics of Benzo(a)pyrene Uptake, Biotransformation, and DNA Adduct Formation in a Liver Cell Model

Kristin Schirmer

Cell-based models are important for deriving mechanistic information about stress response pathways that have evolved to protect cells from toxic insult, such as exposure to environmental pollutants. One determinant of the stress response is the amount of ...

Amer Chemical Soc2014

Differential stress reaction of human colon cells to oleic-acid-stabilized and unstabilized ultrasmall iron oxide nanoparticles

Therapeutic engineered nanoparticles (NPs), including ultrasmall superparamagnetic iron oxide (USPIO) NPs, may accumulate in the lower digestive tract following ingestion or injection. In order to evaluate the reaction of human colon cells to USPIO NPs, th ...

Dove Medical Press Ltd2014

Scleractinian coral cell proliferation is reduced in primary culture of suspended multicellular aggregates compared to polyps

Shirit Cohen, Anders Meibom, Agathe Eliette Marie Lecointe, Stéphanie Kéren Cohen, Isabelle Domart-Coulon

Cell cultures from reef-building scleractinian corals are being developed to study the response of these ecologically important organisms to environmental stress and diseases. Despite the importance of cell division to support propagation, cell proliferati ...

Springer2013

Interplay between cytoskeletal forces, membrane tension and shape in rapidly migrating cells

Chiara Gabella

Cell migration is a fundamental process in all animal cells. The ability of cell to migrate is crucial for many pathological and physiological conditions such as morphogenesis, the immune response to inflammatory or vascular diseases and cancer metastasis. ...

EPFL2013