Publications associées à Successful MRI-Guided Focused Ultrasound Thalamotomy after Ipsilateral Gamma Knife Radiosurgery for Essential Tremor: A Case Report with Video

Normalization of aberrant pretherapeutic dynamic functional connectivity of extrastriate visual system in patients who underwent thalamotomy with stereotactic radiosurgery for essential tremor: a resting-state functional MRI study

Jean-Philippe Thiran, Meritxell Bach Cuadra, Dimitri Nestor Alice Van De Ville, Elena Najdenovska, Thomas William Arthur Bolton, Constantin Tuleasca

OBJECTIVE The tremor circuitry has commonly been hypothesized to be driven by one or multiple pacemakers within the cerebello-thalamo-cortical pathway, including the cerebellum, contralateral motor thalamus, and primary motor cortex. However, previous stud ...

2020

Pretherapeutic resting-state fMRI profiles are associated with MR signature volumes after stereotactic radiosurgical thalamotomy for essential tremor

Jean-Philippe Thiran, Meritxell Bach Cuadra, Dimitri Nestor Alice Van De Ville, Elena Najdenovska, Thomas William Arthur Bolton, Constantin Tuleasca, Adrien Jean Régis Maurice Hilaire

OBJECTIVE Essential tremor (ET) is the most common movement disorder. Drug-resistant ET can benefit from standard stereotactic deep brain stimulation or radiofrequency thalamotomy or, alternatively, minimally invasive techniques, including stereotactic rad ...

AMER ASSOC NEUROLOGICAL SURGEONS2018

System Design and Advanced Circuit Techniques for Bi-Directional Brain-Machine Interfaces

Wen-Yang Hsu

Bi-directional brain-machine interfaces (BBMIs) that can capture electrophysiological signals and provide feedback through electrical stimulation are emerging tools with various applica-tions in fundamental neuroscience research as well as in clinical trea ...

EPFL2018

Medial Forebrain Bundle Deep Brain Stimulation has Symptom-specific Anti-depressant Effects in Rats and as Opposed to Ventromedial Prefrontal Cortex Stimulation Interacts With the Reward System

Martin Vogel

Background: In recent years, deep brain stimulation (DBS) has emerged as a promising treatment option for patients suffering from treatment-resistant depression (TRD). Several stimulation targets have successfully been tested in clinical settings, includin ...

Elsevier Science Inc2015

Exploring the pathological interaction between LRRK2 and alpha-synuclein : two key genes implicated in Parkinson's disease

Alessandra Musso

Parkinson’s disease (PD) is the most common age-related neurodegenerative movement disorder that affects 1-2% of the general population over the age of 65 and rising to 4-5% over 80 years of age. It is estimated that 6.3 million people worldwide have Parki ...

EPFL2014

Wireless Power Transfer and Data Communication for Intracranial Neural Implants Case Study : Epilepsy Monitoring

Gürkan Yilmaz

Recording neural activities plays an important role in numerous applications ranging from brain mapping to implementation of brain-machine interfaces (BMI) to recover lost functions or to understand the mechanisms behind the neurological disorders such as ...

EPFL2014

Effect of realistic modeling of deep brain stimulation on the prediction of volume of active tissue

Juan Ramon Mosig, Laleh Golestanirad

Deep brain stimulation (DBS) is a well-established treatment for Parkinson's disease, essential tremor and dystonia. It has also been successfully applied to treat various other neurological and psychiatric conditions including depression and obsessive-com ...

2012

Quantification of tremor and bradykinesia in Parkinson’s disease using a novel ambulatory monitoring system

Kamiar Aminian, Arash Salarian

An ambulatory system for quantification of tremor and bradykinesia in patients with Parkinson's disease (PD) is presented. To record movements of the upper extremities, a sensing units which included miniature gyroscopes, has been fixed to each of the fore ...

2007

A Cross Validation Study of Deep Brain Stimulation Targeting: From Experts to Atlas-Based, Segmentation-Based and Automatic Registration Algorithms

Jean-Philippe Thiran, Meritxell Bach Cuadra, Olivier Cuisenaire, Reto Meuli, Francisco Javier Sanchez Castro

Validation of image registration algorithms is a difficult task and open-ended problem, usually application-dependent. In this paper we focus on deep brain stimulation (DBS) targeting for the treatment of movement disorders like Parkinson's disease and ess ...

Institute of Electrical and Electronics Engineers2006

Ambulatory monitoring of motor functions in patients with Parkinson's disease using kinematic sensors

Arash Salarian

Parkinson's disease (PD) is the second most common neurodegenerative disease in the general population. Cardinal symptoms of Parkinson's disease are resting tremor, rigidity, akinesia and bradykinesia and in advanced stages, gait impairments, postural inst ...

EPFL2006

Perceptual learning with spatial uncertainties

Michael Herzog, Thomas Otto

In perceptual learning, stimuli are usually assumed to be presented to a constant retinal location during training. However, due to tremor, drift, and microsaccades of the eyes, the same stimulus covers different retinal positions on sequential trials. Bec ...

Elsevier2006