Publications associées à Clinical implementation of accelerated T-2 mapping: Quantitative magnetic resonance imaging as a biomarker for annular tear and lumbar disc herniation

Quantitative T2 Mapping of Acute Pancreatitis

Background: Quantification of the T2 signal by means of T2 mapping in acute pancreatitis (AP) has the potential to quantify the parenchymal edema. Quantitative T2 mapping may overcome the limitations of previously reported scoring systems for reliable asse ...

Wiley2024

Lumbar discectomy with annulus fibrosus closure: A retrospective series of 53 consecutive patients

Constantin Tuleasca

Introduction. - Lumbar disc herniation is most common degenerative alteration of the spine. Whenever surgical therapy proves to be necessary, recurrent disc herniation is most frequent concern. Here, primary aim was to determine the percentage of patients ...

2022

Gait Variability to Phenotype Common Orthopedic Gait Impairments Using Wearable Sensors

Amir Muaremi, Wei Zhang

Mobility impairments are a common symptom of age-related degenerative diseases. Gait features can discriminate those with mobility disorders from healthy individuals, yet phenotyping specific pathologies remains challenging. This study aims to identify if ...

MDPI2022

Value of T-2 Mapping MRI for Prostate Cancer Detection and Classification

Tom Hilbert

Background Currently, multi-parametric prostate MRI (mpMRI) consists of a qualitative T-2, diffusion weighted, and dynamic contrast enhanced imaging. Quantification of T-2 imaging might further standardize PCa detection and support artificial intelligence ...

WILEY2022

Lumbar and thoracic kinematics during step-up: Comparison of three-dimensional angles between patients with chronic low back pain and asymptomatic individuals

Julien Favre, Brigitte Jolles-Haeberli, Guillaume Christe

While alterations in spinal kinematics have been repeatedly observed in patients with chronic low back pain (CLBP), their exact nature is still unknown. Specifically, there is a need for comprehensive assessments of multisegment spinal angles during daily- ...

2020

Gait features for discriminating between mobility-limiting musculoskeletal disorders: Lumbar spinal stenosis and knee osteoarthritis

Amir Muaremi, Wei Zhang

Background: Functional ambulation limitations are features of lumbar spinal stenosis (LSS) and knee osteoarthritis (OA). With numerous validated walking assessment protocols and a vast number of spatiotemporal gait parameters available from sensor-based as ...

ELSEVIER IRELAND LTD2020

Patient respiratory-triggered quantitative T-2 mapping in the pancreas

Reto Meuli, Tobias Kober, Josefina Adriana Maria Bastiaansen, Tom Hilbert

Background Long acquisition times and motion sensitivity limit T-2 mapping in the abdomen. Accelerated mapping at 3 T may allow for quantitative assessment of diffuse pancreatic disease in patients during free-breathing. Purpose To test the feasibility of ...

2019

Model-based super-resolution reconstruction of T-2 maps

Jean-Philippe Thiran, Reto Meuli, Mohammad Golbabaee, Tobias Kober, Tom Hilbert, Gian Franco Piredda, Wajiha Bano

Purpose High-resolution isotropic T-2 mapping of the human brain with multi-echo spin-echo (MESE) acquisitions is challenging. When using a 2D sequence, the resolution is limited by the slice thickness. If used as a 3D acquisition, specific absorption rate ...

Wiley2020

Magnetization transfer in magnetic resonance fingerprinting

Tobias Kober, Tom Hilbert

Purpose To study the effects of magnetization transfer (MT, in which a semi-solid spin pool interacts with the free pool), in the context of magnetic resonance fingerprinting (MRF). Methods Simulations and phantom experiments were performed to study the im ...

WILEY2020

Fast model-based T-2 mapping using SAR-reduced simultaneous multislice excitation

Jean-Philippe Thiran, Gunnar Krüger, Tobias Kober, José Pedro Rebelo Ferreira Marques, Tom Hilbert

Purpose To obtain whole-brain high-resolution T-2 maps in 2 minutes by combining simultaneous multislice excitation and low-power PINS (power independent of number of slices) refocusing pulses with undersampling and a model-based reconstruction. Methods A ...

WILEY2019

Regional T-1 mapping of the whole cervical spinal cord using an optimized MP2RAGE sequence

Tobias Kober

While T1 measurements present multiple challenges (robustness, acquisition time), the recently proposed MP2RAGE sequence (magnetization-prepared two rapid acquisition gradient echoes) has opened new perspectives to characterize tissue microstructure change ...

WILEY2019

Tailoring swelling to control softening mechanisms during cyclic loading of PEG/cellulose hydrogel composites

Dominique Pioletti, Pierre-Etienne Bourban, Azadeh Khoushabi, Céline Samira Wyss, Baris Çaglar

One of the novel approaches for discogenic lower back pain treatment is to permanently replace the core of the intervertebral disc, so-called Nucleus Pulposus, through minimally invasive surgery. Recently, we have proposed Poly(Ethylene Glycol) Dimethacryl ...

2018

A Closed-Loop EMG-Assisted Shoulder Model

Ehsan Sarshari

The human shoulder is a complex musculoskeletal system. Knowledge about its kinematics and dynamics can help improve associated treatments. However, to date direct measurements of these quantities can be only granted through invasive investigations or expe ...

EPFL2018

Chronic low back pain patients walk with locally altered spinal kinematics

Julien Favre, Brigitte Jolles-Haeberli, Guillaume Christe

Various studies have reported alterations of spinal kinematics in patients with chronic low back pain (CLBP) during gait. However, while recent findings stressed the importance of multi-segment analysis, most of prior gait studies modelled the lumbar spine ...

Elsevier Sci Ltd2017

Surgical probe and implant development for nucleus pulposus replacements

Andreas Schmocker

Intervertebral disc degeneration is a major reason why we experience low back pain. Intervertebral discs are located in-between the vertebrae of the spine. They act, among other, as shock absorbers by distributing the mechanical load applied to the spine w ...

EPFL2016

A photopolymerized composite hydrogel and surgical implanting tool for a nucleus pulposus replacement

Dominique Pioletti, Pierre-Etienne Bourban, Andreas Schmocker, Azadeh Khoushabi, Christophe Moser

Nucleus pulposus replacements have been subjected to highly controversial discussions over the last 40 years. Their use has not yet resulted in a positive outcome to treat herniated disc or degenerated disc disease. The main reason is that not a single imp ...

Elsevier2016

Multi-segment analysis of spinal kinematics during sit-to-stand in patients with chronic low back pain

Julien Favre, Thomas Legrand, Guillaume Christe

While alterations in spinal kinematics have been frequently reported in patients with chronic low back pain (CLBP), a better characterization of the kinematics during functional activities is needed to improve our understanding and therapeutic solutions fo ...

Elsevier Sci Ltd2016

Nano Fibrillated Cellulose Based Composite Hydrogels for an Injectable Intervertebral Disc Implant

Azadeh Khoushabi

Replacing the gel-like central part of the intervertebral disc (IVD), so-called nucleus pulposus (NP), via a minimally invasive surgery is one of the most recent approaches in the lower back pain treatments. An appropriate biomaterial for NP replacement (N ...

EPFL2016

Patient-specific spinal stiffness in AIS: a preoperative and noninvasive method

Steve Michel Berger

The clinical tests currently used to assess spinal biomechanics preoperatively are unable to assess true mechanical spinal stiffness. They rely on spinal displacement without considering the force required to deform a patient's spine. We propose a preopera ...

Springer2015

Development of an in situ controllable polymerization tool and process for hydrogel used to replace nucleus pulposus

Dominique Pioletti, Pierre-Etienne Bourban, Andreas Schmocker, Azadeh Khoushabi, Christophe Moser

Currently implants or tissue replacements are inserted either as a whole implant or by injecting a liquid which polymerizes to form a solid implant at the appropriate location. This is either highly invasive or not controllable. We developed a tool to perf ...

Spie-Int Soc Optical Engineering2015