Publications associées à Anisotropic behaviour of shallow opalinus clay

Adolescent Stress-Induced Ventral Hippocampus Redox Dysregulation Underlies Behavioral Deficits and Excitatory/Inhibitory Imbalance Related to Schizophrenia

Maria del Carmen Sandi Perez, Dogukan Hazar Ülgen, Thamyris Silva

Background and hypothesis: Redox dysregulation has been proposed as a convergent point of childhood trauma and the emergence of psychiatric disorders, such as schizophrenia (SCZ). A critical region particularly vulnerable to environmental insults during ad ...

2024

Microbial hydrogen sinks in the sand-bentonite backfill material for the deep geological disposal of radioactive waste

Rizlan Bernier-Latmani, Manon Frutschi, Niels Burzan, Aislinn Ann Boylan, Nicolas Louis Maurice Jacquemin, Simiao Wang, Camille Aude Rolland

The activity of subsurface microorganisms can be harnessed for engineering projects. For instance, the Swiss radioactive waste repository design can take advantage of indigenous microorganisms to tackle the issue of a hydrogen gas (H2) phase pressure build ...

Frontiers Media SA2024

Thermo-hydro-mechanical behaviour of the Callovo-Oxfordian claystone under thermal changes

Héloïse Manon Fuselier

Underground storage of radioactive waste is consensually recognised as the safest storage solution by European and worldwide countries relying mainly or partially on nuclear energy production. Over twenty years of research led by the French national agency ...

EPFL2024

Evolution of water content and suction of Opalinus Clay from recovery at the drilling site to handling in the laboratory

Lyesse Laloui, Alessio Ferrari, Angelica Tuttolomondo

Advanced geotechnical engineering applications, such as shale gas extraction, CO2 geological sequestration, and geological radioactive waste storage, often involve various types of shales located at significant depths. Shales exhibit mechanical properties ...

Pergamon-Elsevier Science Ltd2024

A FEM modelling workflow to simulate THM effects in the rock around nuclear waste packages

Matthias Timothee Stanislas Wojnarowicz

High-level waste, stemming from nuclear electricity generation poses significant environmental and safety concerns. Currently, high-level wastes are stored in interim facilities needing constant monitoring and waiting for a definitive solution. Deep geolog ...

EPFL2024

Experimental and analytical investigation of shear-reinforced concrete and dowel action

Marko Pejatovic

Codes of practice can be overly conservative, particularly for the shear resistance of reinforced concrete beams with shear reinforcement when large loads act close to supports. This thesis addresses the topic by proposing a refined design approach based o ...

EPFL2024

Hydro-Mechanical Characterization of a Shale by Unusually High-Pressure Oedometric Tests

Alessio Ferrari, Eleonora Crisci

The note presents selected results of an experimental campaign conducted with the aim to investigate the hydro-mechanical behaviour of a shale recovered at a depth of about 900 m below the ground. High-pressure oedometric tests were performed to investigat ...

Wei Wu, Universität für Bodenkultur2023

Thermo-hydro-mechanical analysis of the complete lifetime of the bentonite barrier in the FEBEX in-situ test

Lyesse Laloui, Alessio Ferrari, Yafei Qiao, Jose Antonio Bosch Llufriu

The FEBEX test was a large-scale demonstration project for the deep geological disposal concept of nuclear waste involving bentonite seals that lasted 18 years. One of the objectives of the test was to evaluate the capabilities of numerical methods to prov ...

2023

Pore-pressure coefficients for unsaturated soils: generalized effective stress approach

Lyesse Laloui, Alessio Ferrari, Angelica Tuttolomondo

Geotechnical problems with total stress changes occurring rapidly relative to the soil consolidation time can be conveniently addressed using an effective stress-based approach. For saturated states, analytical formulations of pore-pressure coefficients ad ...

CANADIAN SCIENCE PUBLISHING2023

Transcriptomic analysis reveals mitochondrial pathways associated with distinct adolescent behavioral phenotypes and stress response

Maria del Carmen Sandi Perez, Dogukan Hazar Ülgen, Thamyris Silva

Adolescent individuals exhibit great variability in cortical dynamics and behavioral outcomes. The developing adolescent brain is highly sensitive to social experiences and environmental insults, influencing how personality traits emerge. A distinct patter ...

2023

Psychosomatic response to acute emotional stress in healthy students

Adriana Arza Valdes

The multidimensionality of the stress response has shown the complexity of this phenomenon and therefore the impossibility of finding a unique biomarker among the physiological variables related to stress. An experimental study was designed and performed t ...

FRONTIERS MEDIA SA2023

'connEcted caesarean section': creating a virtual link between MOthers and their infanTs to ImprOve maternal childbirth experieNce - study protocol for a PILOT trial (e-motion-pilot)

Sandra Maria Marcadent, Karine Lepigeon, Fiona Corbaz, David Desseauve

IntroductionOne-third of mothers rate their childbirth as traumatic. The prevalence of childbirth-related post-traumatic stress disorder (CB-PTSD) is 4.7%. Skin-to-skin contact is a protective factor against CB-PTSD. However, during a caesarean section (CS ...

BMJ PUBLISHING GROUP2023

Crack tip kinematics reveal the process zone structure in brittle fracture

John Martin Kolinski, Chenzhuo Li, Xinyue Wei

When brittle hydrogels fail, several mechanisms conspire to alter the state of stress near the tip of a crack, and it is challenging to identify which mechanism is dominant. In the fracture of brittle solids, a sufficient far-field stress results in the co ...

PERGAMON-ELSEVIER SCIENCE LTD2023

Blunted Glucocorticoid Responsiveness to Stress Causes Behavioral and Biological Alterations That Lead to Posttraumatic Stress Disorder Vulnerability

Maria del Carmen Sandi Perez, Olivia Zanoletti, Jocelin Grosse, Sophie Elizabeth Walker, Marie-Isabelle Guillot de Suduiraut, Simone Astori, Silvia Monari

Background: Understanding why only a subset of trauma-exposed individuals develop posttraumatic stress disorder is critical for advancing clinical strategies. A few behavioral (deficits in fear extinction) and biological (blunted glucocorticoid levels, sma ...

2023

Single-Well Pore Pressure Preconditioning for Enhanced Geothermal System Stimulation

Marie Estelle Solange Violay, Barnaby Padraig Fryer, Mathias Alexandre David Lebihain

The stress state is an important parameter in terms of both earthquake nucleation and rupture. Here, a new stimulation technique is proposed for Enhanced Geothermal Systems (EGSs), which have previously been burdened with a number of high-profile incidence ...

2023

Experimental and Numerical Investigation on Water Exchange of Opalinus Clay Samples

Alessio Ferrari, Qazim Llabjani, Eleni Stavropoulou, Vincenzo Sergio Vespo

Opalinus Clay is a fine-grained sedimentary geomaterial with a mineral composition consisting mainly of silicates, carbonates and quartz. Due to its favourable barrier properties, this geomaterial has been selected as the host rock for the underground disp ...

Wei Wu, Universität für Bodenkultur2023

The effects of war on Ukrainian research

Gaétan Jean A de Rassenfosse, Wolf-Hendrik Peter Uhlbach, Tetiana Murovana

The ongoing war in Ukraine has profoundly impacted the Ukrainian scientific community. Numerous researchers have either emigrated or transitioned to alternate professions. For those who remain in research, the destruction of civil infrastructure and psycho ...

Springernature2023

Fatigue behavior of transverse attachments under constant and variable amplitude loading from a Swiss motorway bridge

Alain Nussbaumer, Davide Leonetti, Yukina Takai

This paper investigates the fatigue behavior of non-load-carrying transverse welded steel attachments by reporting on an experimental characterization under constant and variable amplitude loading. Fatigue cracks have been monitored using DIC and ACPD tech ...

Elsevier Sci Ltd2023

Genetic selection for low glucocorticoid responsiveness recapitulates PTSD-related phenotypes: a behavioral, neuroimaging and sleep-physiology study

Silvia Monari

Humans show inter-individual differences in vulnerability to develop post-traumatic stress disorder (PTSD) following exposure to trauma. Several critical biobehavioral features have been consistently described in PTSD patients, including blunted cortisol l ...

EPFL2022

Opposite effects of stress on effortful motivation in high and low anxiety are mediated by CRHR1 in the VTA

Maria del Carmen Sandi Perez, Olivia Zanoletti, Jocelin Grosse, Marie-Isabelle Guillot de Suduiraut, Ioannis Zalachoras, Simone Astori, Mandy Meijer

Individuals frequently differ in their behavioral and cognitive responses to stress. However, whether motivation is differently affected by acute stress in different individuals remains to be established. By exploiting natural variation in trait anxiety in ...

2022