Publications associées à Integrated field, laboratory, and theoretical study of PKD spread in a Swiss prealpine river

Effects of water releases and sediment supply on a residual flow reach

Giovanni De Cesare, Camille Blanck, Robin Schroff

An artificial floods program has been implemented on the Sarine residual flow reach, downstream of the Rossens dam. Two artificial floods were released in 2016 (coupled with sediment augmentation) and in 2020. A natural flood occurred in 2021. The indicato ...

CRC Press/Balkema2023

Evaluation of tire tread particle toxicity to fish using rainbow trout cell lines

Florian Frédéric Vincent Breider, Kristin Schirmer, Benoît Jean Dominique Ferrari, Gabrielle Léger, Thibault Béranger Masset

Tire and road wear particles (TRWP) resulting from tire abrasion while driving raise concerns due to their potential contribution to aquatic toxicity. Our study aimed to assess cryogenically milled tire tread (CMTT) particle toxicity, used as a proxy for T ...

2023

Bioaccessibility of Organic Compounds Associated with Tire Particles Using a Fish In Vitro Digestive Model: Solubilization Kinetics and Effects of Food Coingestion

Dominique Grandjean, Florian Frédéric Vincent Breider, Kristin Schirmer, Luke Christopher Harris, Benoît Jean Dominique Ferrari, Thibault Béranger Masset

Tire and road wear particles (TRWP) account for an important part of the polymer particles released into the environment. There are scientific knowledge gaps as to the potential bioaccessibility of chemicals associated with TRWP to aquatic organisms. This ...

2022

Wirkungskontrolle einer Sedimentzugabe: Habitatvielfalt und Kolmation

Giovanni De Cesare, Christian Mörtl, Robin Schroff

In einer Restwasserstrecke der Saane wurde 2016 zur Sanierung der kolmatierten Gewässersohle und zur Aufwertung der Lebensräume ein künstliches Hochwasser ausgelöst und mit einer Sedimentzugabe gekoppelt. Die mittelfristigen Wirkungen der Sedimentzugabe wu ...

2021

In vitro acute toxicity assessment of tire tread particles using rainbow trout cell lines of gill and intestine

Florian Frédéric Vincent Breider, Kristin Schirmer, Benoît Jean Dominique Ferrari, Thibault Béranger Masset

Tire and road wear particles (TRWP) are generated by the abrasion of tires while driving, and recent questions were raised in regards to their potential contribution to microplastics released into the aquatic environment and their potential toxicological i ...

2021

A ribonucleoprotein transfection strategy for CRISPR/Cas9-mediated gene editing and single cell cloning in rainbow trout cells

Kristin Schirmer

Background The advent of the Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/Cas9 technology marked the beginning of a new era in the field of molecular biology, allowing the efficient and precise creation of targeted mutations in the ge ...

2021

Extending the Concept of Predicting Fish Acute Toxicity In Vitro to the Intestinal Cell Line RTgutGC

Kristin Schirmer, Hannah Inka Schug, Jenny Maner

Testing chemicals for fish acute toxicity is a legal requirement in many countries as part of environmental risk assessment. To reduce the number of fish used, substantial efforts have been focused on alternative approaches. Prominently, the cell viability ...

2020

Effects of altered river network connectivity on the distribution of Salmo trutta: Insights from a metapopulation model

Andrea Rinaldo, Enrico Bertuzzo, Luca Carraro, Alexia Maria Gonzalez Ferreras

Network connectivity is a key feature of rivers that affects patterns and processes in lotic ecosystems. Few studies have considered how changes in river reach connectivity might affect ecosystem attributes at a whole river network scale. The use of popula ...

WILEY2019

Fish-gut-on-chip: development of a microfluidic bioreactor to study the role of the fish intestine in vitro

Philippe Renaud, Kristin Schirmer, Carolin Drieschner, Sarah-Katharina Könemann

In this study we present the first fish-gut-on-chip model. This model is based on the reconstruction of the intestinal barrier by culturing two intestinal cell lines from rainbow trout, namely epithelial RTgutGC and fibroblastic RTgutF, in an artificial mi ...

2019

Percolation and Internet Science

Emanuele Massaro

Percolation, in its most general interpretation, refers to the “flow” of something (a physical agent, data or information) in a network, possibly accompanied by some nonlinear dynamical processes on the network nodes (sometimes denoted reaction–diffusion s ...

2019

A fish intestinal barrier model to assess the interaction with chemicals in vitro

Hannah Inka Schug

The intestinal epithelium acts as vital gate keeper between the fish and its surrounding environment. A single layer of connected epithelial cells forms a selective barrier, which, among other essential functions, is important for nutrient uptake and defen ...

EPFL2019

Ecohydrological and Metacommunity Studies of Proliferative Kidney Disease Spread in Freshwater Salmonid Fish

Luca Carraro

Proliferative kidney disease (PKD) is a high-mortality pathology affecting freshwater salmonid populations in Europe and North America. Its causative agent, the myxozoan Tetracapsuloides bryosalmonae, has a complex life-cycle exploiting freshwater bryozoan ...

EPFL2018

Spread of proliferative kidney disease in fish along stream networks: A spatial metacommunity framework

Andrea Rinaldo, Enrico Bertuzzo, Lorenzo Mari, Marino Gatto, Luca Carraro

Proliferative kidney disease (PKD) is a high-mortality pathology that critically affects freshwater salmonid populations. Infection is caused by the endoparasitic myxozoan Tetracapsuloides bryosalmonae, which exploits freshwater bryozoans as primary hosts. ...

2018

What is the role of fish intestine as environment-organism barrier? Mechanistic investigations using fish intestinal cells on a chip

Carolin Drieschner

The gut of fish belongs to the most essential barriers that mark the border between the organism and its surrounding environment. The pivotal barrier function, allowing to absorb nutrients from the diet while simultaneously protecting the organism from pat ...

EPFL2018

TransFEr: a new device to measure the transfer of volatile and hydrophobic organic chemicals across an in vitro intestinal fish cell barrier

Kristin Schirmer, Hannah Inka Schug

Transfer of compounds across cellular barriers is a critical step of compound uptake into organisms. Using in vitro barrier systems to evaluate such transfer is attractive because of the higher throughput and reduced resource needs compared to animal studi ...

ROYAL SOC CHEMISTRY2018

An ecological and digital epidemiology analysis on the role of human behavior on the 2014 Chikungunya outbreak in Martinique

Marcel Salathé

Understanding the spatio-temporal dynamics of endemic infections is of critical importance for a deeper understanding of pathogen transmission, and for the design of more efficient public health strategies. However, very few studies in this domain have foc ...

Nature Research2017

Spatially explicit modeling of cholera epidemics

Flavio Finger

Understanding the epidemiology of cholera, when and where it occurs and how it spreads, is key to its prevention and control. Models can help to apprehend cholera outbreaks by providing insight into critical epidemiological processes, and may be used to ev ...

EPFL2017

Heterogeneity in schistosomiasis transmission dynamics

Andrea Rinaldo, Enrico Bertuzzo, Francisco Javier Perez Saez, Lorenzo Mari, Marino Gatto

Simple models of disease propagation often disregard the effects of transmission heterogeneity on the ecological and epidemiological dynamics associated with host-parasite interactions. However, for some diseases like schistosomiasis, a widespread parasiti ...

Academic Press Ltd- Elsevier Science Ltd2017

An epidemiological model for proliferative kidney disease in salmonid populations

Andrea Rinaldo, Enrico Bertuzzo, Lorenzo Mari, Marino Gatto, Luca Carraro

Background: Proliferative kidney disease (PKD) affects salmonid populations in European and North-American rivers. It is caused by the endoparasitic myxozoan Tetracapsuloides bryosalmonae, which exploits freshwater bryozoans and salmonids as hosts. Inciden ...

Biomed Central Ltd2016

Statistical physics of vaccination

Marcel Salathé, Zhen Wang

Historically, infectious diseases caused considerable damage to human societies, and they continue to do so today. To help reduce their impact, mathematical models of disease transmission have been studied to help understand disease dynamics and inform pre ...

Elsevier Science Bv2016