Publications associées à In vivo measurement of the tissue oxygenation by time-resolved luminescence spectroscopy of protoporphyrin IX: Strategies to minimize artefacts associated with photoproducts

Hemoglobin-stabilized gold nanoclusters displaying oxygen transport ability, self-antioxidation, auto-fluorescence properties and long-term storage potential

The development of hemoglobin (Hb)-based oxygen carriers (HBOCs) holds a lot of potential to overcome important drawbacks of donor blood such as a short shelf life or the potential risk of infection. However, a crucial limitation of current HBOCs is the au ...

ROYAL SOC CHEMISTRY2023

Porphyrin metalla-assemblies coupled to cellulose nanocrystals for PDT and imaging applications

Georges Wagnières

Photodynamic therapy (PDT) is an interesting and promising approach to tackle a broad spectrum of cancer. With the combination of a photosensitizer, light and oxygen, PDT achieves a unique selectivity by the production of localized reactive oxygen species ...

WORLD SCIENTIFIC PUBL CO PTE LTD2023

The influence of the gas on the dynamics of cavitation bubbles

Davide Bernardo Preso

Cavitation bubbles, extensively investigated in fluid mechanics, present enduring challenges in hydraulic machinery, while holding considerable potential for practical applications in biomedicine and sonochemistry. Despite more than a century of research, ...

EPFL2023

2.5 Hz sample rate time-domain near-infrared optical tomography based on SPAD-camera image tissue hemodynamics

Edoardo Charbon, Scott Anthony Lindner, Jingjing Jiang, Martin Wolf

Tim-domain near-infrared optical tomography (TD NIROT) techniques based on diffuse light were gaining performance over the last years. They are capable of imaging tissue at several centimeters depth and reveal clinically relevant information, such as tissu ...

OPTICAL SOC AMER2022

Performance of the new SmartCardia wireless, wearable oximeter: a comparison with arterial SaO2 in healthy volunteers

Srinivasan Murali, Francisco Javier Rincon Vallejos, Julien Pidoux

Background Our goal was to evaluate the performance of a new wearable arm located pulse oximeter. Methods Twelve volunteers were monitored with three pulse oximeters and underwent desaturation to 70% SaO(2). We compared the accuracy of SpO(2) reading from ...

BMC2022

Electron probing of oxygen-evolving oxide catalysts

Tzu-Hsien Shen

Water splitting is one of the cleanest ways to store energy. The production of hydrogen and oxygen gases can be utilized in fuel cells to generate electricity, power, and heat. In the water splitting process, the oxygen evolution reaction (OER), taking pla ...

EPFL2022

Identifying the mediators of intracellular E. coli inactivation under UVA light: The (photo) Fenton process and singlet oxygen

César Pulgarin, Stefanos Giannakis

Solar disinfection (SODIS) was probed for its underlying mechanism. When Escherichia coli was exposed to UVA irradiation, the dominant solar fraction acting in SODIS process, cells exhibited a shoulder before death ensued. This profile resembles cell killi ...

PERGAMON-ELSEVIER SCIENCE LTD2022

Stimulation and homogenization of the protoporphyrin IX endogenous production by photobiomodulation to increase the potency of photodynamic therapy

Georges Wagnières, Emmanuel Louis Arthur Gerelli, Jaroslava Joniová, Cyrus Kazemiraad

Protoporphyrin IX (PpIX) is produced in the mitochondria and used as fluorescent contrast agent or photosensitizer after exogenous 5-aminolevulinic acid (ALA) delivery in cancer photodynamic detection and therapy (PDT). Although routinely used in the clini ...

ELSEVIER SCIENCE SA2021

Influence of Oxidative Stress on Time-Resolved Oxygen Detection by [Ru(Phen)3]2+ In Vivo and In Vitro

Georges Wagnières, Veronika Huntosova

Detection of tissue and cell oxygenation is of high importance in fundamental biological and in many medical applications, particularly for monitoring dysfunction in the early stages of cancer. Measurements of the luminescence lifetimes of molecular probes ...

2021

Defect engineered nanostructured LaFeO3 photoanodes for improved activity in solar water oxidation

Mounir Driss Mensi, Kevin Sivula, Xavier Pereira Da Costa, Nestor Guijarro Carratala, Liang Yao, Yongpeng Liu

LaFeO3 (LFO) is recognized as a candidate material for solar water oxidation, but its photoelectrochemical response remains modest and stagnant. With the aim of advancing LFO photoanodes for the oxygen evolution reaction (OER), here, a nanorod array-type e ...

Royal Society of Chemistry2021

Hypoxia Conditioning as a Promising Therapeutic Target in Parkinson's Disease?

Hilal Lashuel, Grégoire Millet, Johannes Burtscher, Muhammed Muazzam Kamil Syed

Several lines of research point to a key role of low oxygen supply (hypoxia) in Parkinson's disease pathogenesis. Although severe hypoxia is detrimental for the brain, physiological adaptations to mild hypoxia are neuroprotective. Herein we discuss, how ne ...

WILEY2021

Oxygen availability in a HAPE-positive and a HAPE-negative woman before and during a visit to 3480 meters

Johannes Burtscher

Background: Testing the hypoxic ventilatory response (HVR) at low-altitude helps to detect those who do not hyperventilate appropriately in hypoxia but might not necessarily predict the HVR and the risk to develop acute mountain sickness (AMS) at high alti ...

ELSEVIER2020

A general framework for non-exponential delayed fluorescence and phosphorescence decay analysis, illustrated on Protoporphyrin IX

Georges Wagnières, Aurelien Stephen Arnaud Gregor, Emmanuel Louis Arthur Gerelli, Jaroslava Joniová

Delayed fluorescence (DF) is a long-lived luminescence process used in a variety of applications ranging from oxygen sensing in biological tissues to organic Light Emitting Diodes. In common cases, DF results from the deexcitation of the first excited trip ...

2020

Impact of oxygen content in powders on the morphology of the laser molten tracks in preparation for additive manufacturing of silicon

Patrik Willi Hoffmann, Lucas Güniat, Marc Leparoux

Powder additive pulsed Nd:YAG laser (wavelength 1064 nm), with the aim of preparing AM of such material. The influence of oxygen content in the initial silicon powders on the continuous tracks morphology was investigated. It was found that the initial oxyg ...

ELSEVIER2020

Catechin reduces phototoxic effects induced by protoporphyrin IX-based photodynamic therapy in the chick embryo chorioallantoic membrane

Georges Wagnières, Jaroslava Joniová

Significance: Side effects of many cancer treatments are associated with the production of reactive oxygen species (ROS) in normal tissues. This explains why patients treated by photodynamic therapy (PDT) often suffer from skin photosensitization, whereas ...

SPIE Society of Photo-optical Instrumentation Engineers2020

Repetitive Erythropoietin Treatment Improves Long-Term Neurocognitive Outcome by Attenuating Hyperoxia-Induced Hypomyelination in the Developing Brain

Yohan Van de Looij

Introduction:Preterm infants born before 28 weeks of gestation are at high risk of neurodevelopmental impairment in later life. Cerebral white and gray matter injury is associated with adverse outcomes. High oxygen levels, often unavoidable in neonatal int ...

FRONTIERS MEDIA SA2020

Role of Iron Sulfide Phases in the Stability of Noncrystalline Tetravalent Uranium in Sediments

Rizlan Bernier-Latmani, Luca Loreggian

Uranium (U) in situ bioremediation has been investigated as a cost-effective strategy to tackle U contamination in the subsurface. While uraninite was believed to be the only product of bioreduction, numerous studies have revealed that noncrystalline U(IV) ...

AMER CHEMICAL SOC2020

Generation of hydroxyl radical during chlorination of hydroxyphenols and natural organic matter extracts

Urs von Gunten, Eva Maria Rodriguez Franco

The generation of hydroxyl radicals ((OH)-O-center dot) during the chlorination of air saturated solutions of different hydroxyphenols (hydroquinone, resorcinol, catechol, gallic and tannic acids) at pH 7 has been determined by the formation of phenol (in ...

2020

Photoprotective effect of catechin during ALA-PDT

Georges Wagnières, Jaroslava Joniová

The production of reactive oxygen species (ROS) in normal tissues is associated with side effects of many cancer treatments. This is, in particular, the case for the skin photosensitization experienced by certain patients subjected to PDT based on a system ...

SPIE-INT SOC OPTICAL ENGINEERING2019

Oxygen diffusion through air–water free surfaces in a pump–turbine operating in condenser mode

François Avellan, Elena Vagnoni, Loïc Andolfatto, Pierre Leroy

The present research aims at understanding the mass transfer of air into water in a reversible pump turbine operating in condenser mode. In particular, the diffusion of oxygen through the water free-surface both in the vaneless gap between the impeller bla ...

2019