Publication

The effect of tissue geometry on the activation recovery interval of atrial myocytes

Publications associées (22)

Implementation of an epicardial implantable MEMS sensor for continuous and real-time postoperative assessment of left ventricular activity in adult minipigs over a short- and long-term period

The sensing of left ventricular (LV) activity is fundamental in the diagnosis and monitoring of cardiovascular health in high-risk patients after cardiac surgery to achieve better short- and long-term outcome. Conventional approaches rely on noninvasive me ...

Aip Publishing2024

Finding information-rich electrocardiographic biomarkers to characterize atrial fibrillation

Anna Mary Mc Cann

Atrial fibrillation (AF) is the most common cardiac arrhythmia; it will affect one in four adults worldwide in their lifetime. AF has serious consequences, including drastically increased risk of stroke. Catheter ablation surgery is an established treatmen ...

EPFL2023

Sequential Bone-Marrow Cell Delivery of VEGFA/S1P Improves Vascularization and Limits Adverse Cardiac Remodeling After Myocardial Infarction in Mice

Michele De Palma, Mario Leonardo Squadrito, Magdalena Maria Zak

Microvascular dysfunction and resulting tissue hypoxia is a major contributor to the pathogenesis and evolution of cardiovascular diseases (CVD). Diverse gene and cell therapies have been proposed to preserve the microvasculature or boost angiogenesis in C ...

MARY ANN LIEBERT, INC2019

A transmurally heterogeneous orthotropic activation model for ventricular contraction and its numerical validation

Alfio Quarteroni, Luca Dede', Simone Rossi, Luca Barbarotta

Models for cardiac mechanics require an activation mechanism properly representing the stress-strain relations in the contracting myocardium. In this paper, we propose a new activation model that accounts for the transmural heterogeneities observed in myoc ...

Wiley2018

Upper stimulation threshold for retinal ganglion cell activation

Diego Ghezzi

Objective. The existence of an upper threshold in electrically stimulated retinal ganglion cells (RGCs) is of interest because of its relevance to the development of visual prosthetic devices, which are designed to restore partial sight to blind patients. ...

2018

Cardiac Niche Influences the Direct Reprogramming of Canine Fibroblasts into Cardiomyocyte-Like Cells

Marco Cassano

The Duchenne and Becker muscular dystrophies are caused by mutation of dystrophin gene and primarily affect skeletal and cardiac muscles. Cardiac involvement in dystrophic GRMD dogs has been demonstrated by electrocardiographic studies with the onset of a ...

Hindawi Limited2016

Intercellular ultrafast Ca2+ wave in vascular smooth muscle cells: numerical and experimental study

Jean-Jacques Meister, Niccolo Piacentini, Jairo Camilo Quijano Perez, Franck Claude Raynaud

Vascular smooth muscle cells exhibit intercellular Ca2+ waves in response to local mechanical or KCl stimulation. Recently, a new type of intercellular Ca2+ wave was observed in vitro in a linear arrangement of smooth muscle cells. The intercellular wave w ...

Nature Research2016

Solvability analysis and numerical approximation of linearized cardiac electromechanics

Alfio Quarteroni, Ricardo Esteban Ruiz Baier

This paper is concerned with the mathematical analysis of a coupled elliptic–parabolic system modeling the interaction between the propagation of electric potential and subsequent deformation of the cardiac tissue. The problem consists in a reaction–diffus ...

World Scientific Publ Co Pte Ltd2015

Finite element and finite volume-element simulation of pseudo-ECGs and cardiac alternans

Alfio Quarteroni, Ricardo Esteban Ruiz Baier

In this paper, we are interested in the spatio-temporal dynamics of the transmembrane potential in paced isotropic and anisotropic cardiac tissues. In particular, we observe a specific precursor of cardiac arrhythmias that is the presence of alternans in t ...

Wiley-Blackwell2015

Fluid-structure interaction simulations of cerebral arteries modeled by isotropic and anisotropic constitutive laws

Alfio Quarteroni, Simone Deparis, Luca Dede', Paolo Tricerri, Adélia Sequeira

This paper considers numerical simulations of fluid-structure interaction (FSI) problems in hemodynamics for idealized geometries of healthy cerebral arteries modeled by both nonlinear isotropic and anisotropic material constitutive laws. In particular, it ...

Springer Verlag2015

Self-Navigation with Compressed Sensing for 2D translational Motion Correction in Free-Breathing Coronary MRI: a Feasibility Study

Yves Wiaux, Ruud van Heeswijk, Gilles Puy, Gabriele Vincenzo Bonanno, Davide Piccini

Purpose Respiratory motion correction remains a challenge in coronary magnetic resonance imaging (MRI) and current techniques, such as navigator gating, suffer from sub-optimal scan efficiency and ease-of-use. To overcome these limitations, an image-based ...

Public Library of Science2014

Fully Eulerian finite element approximation of a fluid-structure interaction problem in cardiac cells

Alfio Quarteroni, Ricardo Esteban Ruiz Baier, Aymen Laadhari

We propose in this paper an Eulerian finite element approximation of a coupled chemical fluid-structure interaction problem arising in the study of mesoscopic cardiac biomechanics. We simulate the active response of a myocardial cell (here considered as an ...

Wiley-Blackwell2013

Ultrafast Ca2+ wave in cultured vascular smooth muscle cells aligned on a micropatterned surface

Jean-Jacques Meister, Jean-Louis Bény, Jairo Camilo Quijano Perez, Benoît Vianay

Communication between vascular smooth muscle cells (SMCs) allows control of their contraction and so regulation of blood flow. The contractile state of SMCs is regulated by cytosolic Ca2+ concentration (Ca2+) which propagates as Ca2+ waves over a sign ...

Elsevier2013

Intercellular ultrafast calcium wave in vascular smooth muscle cells

Jairo Camilo Quijano Perez

Communication between vascular smooth muscle cells (SMCs) allows control of their contraction and so regulation of blood flow. The contractile state of SMCs is controled by cytosolic Ca2+ concentration ([Ca2+]i) which propagates as Ca2+ waves over a signif ...

EPFL2013

Measures of spatiotemporal organization differentiate persistent from long-standing atrial fibrillation

Jean-Marc Vesin, Yann Prudat, Lukas Kappenberger, Laurent Renaud Uldry, Jérôme Sébastien Van Zaen

This study presents an automatic diagnostic method for the discrimination between persistent and long-standing atrial fibrillation (AF) based on the surface electrocardiogram (ECG). Standard 12-lead ECG recordings were acquired in 53 patients with either p ...

Oxford Univ Press2012

Kinetics of Atrial Repolarization Alternans in a Free-Behaving Ovine Model

Jean-Marc Vesin, Florian Jousset, Etienne Pruvot

Kinetics of Atrial Repolarization Alternans. Introduction: Repolarization alternans (Re-ALT), a beat-to-beat alternation in action potential repolarization, promotes dispersion of repolarization, wavebreaks, and reentry. Recently, Re-ALT has been shown to ...

Wiley-Blackwell2012

Characterization of Atrial Repolarization Alternans and Activation Time Kinetics based on Intracardiac Electrograms

Florian Jousset

Interdisciplinary collaboration between physicians and engineers is now widespread in fundamental and clinical studies, due to the increasing complexity of the physiological problems tackled, and the development of novel measurement devices and data analys ...

EPFL2011

Regulation of transmitter release by Ca2+ and synaptotagmin: insights from a large CNS synapse

Ralf Schneggenburger, Olexiy Kochubey

Transmitter release at synapses is driven by elevated intracellular Ca2+ concentration (Ca2+) near the sites of vesicle fusion. Ca2+ signals of profoundly different amplitude and kinetics drive the phasic release component during a presynaptic ac ...

2011

Active strain and activation models in cardiac electromechanics

Alfio Quarteroni, Ricardo Esteban Ruiz Baier, Simone Rossi

We present a model for mechanical activation of the cardiac tissue depending on the evolution of the transmembrane electrical potential and certain gating/ionic variables that are available in most of electrophysiological descriptions of the cardiac membra ...

2011

Propagation of fast and slow intercellular Ca2+ waves in primary cultured arterial smooth muscle cells

Jean-Jacques Meister, Jean-Louis Bény, Nadia Halidi

Smooth muscle contraction is regulated by changes in cytosolic Ca2+ concentration (Ca2+). In response to stimulation, Ca2+ increase in a single cell can propagate to neighbouring cells through gap junctions, as intercellular Ca2+ waves. To investigate ...

2011