Publications associées à Interferometric synthetic aperture microscopy for extended focus optical coherence microscopy

Subsurface fluorescence time-of-flight imaging using a large-format single-photon avalanche diode sensor for tumor depth assessment

Claudio Bruschini, Edoardo Charbon, Arin Can Ülkü, Yichen Feng

Significance: Fluorescence guidance is used clinically by surgeons to visualize anatomical and/or physiological phenomena in the surgical field that are difficult or impossible to detect by the naked eye. Such phenomena include tissue perfusion or molecula ...

SPIE Society of Photo-optical Instrumentation Engineers2024

Practical computational imaging by use of spatiotemporal light modulation: from simulations to applications in biological microscopy

François Thierry M Marelli

Optical microscopy is an essential tool for biologists, who are often faced with the need to overcome the spatial and temporal resolution limitations of their devices to capture finer details. As upgrading imaging hardware is expensive, computational metho ...

EPFL2023

Single-shot Kramers-Kronig complex orbital angular momentum spectrum retrieval

Camille Sophie Brès, Jianqi Hu, Yujie Chen

Orbital angular momentum (OAM) spectrum diagnosis is a fundamental building block for diverse OAM-based systems. Among others, the simple on-axis interferometric measurement can retrieve the amplitude and phase information of complex OAM spectra in a few s ...

SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS2023

Exploring Novel Modalities for Optical Diffraction Tomography

Amirhossein Saba Shirvan

In the past decade, optical diffraction tomography has gained a lot of attention for its ability to create label-free three-dimensional (3D) images of the refractive index distribution of biological samples using scattered fields measured through holograph ...

EPFL2023

High sensitivity, incoherent differential imaging

Chiara Bonati

Microscopic visualisation of optically transparent samples has been a topic of interest for several decades. Features such as density or chemical composition can influence the optical phase of transmitted light, and phase contrast can reveal these structur ...

EPFL2022

Advanced Techniques in Optical Diffraction Tomography

Ahmed Bassam Sayed Ayoub Mohamed Emam

In this thesis, we study the 3 challenges described above. First, we study different reconstruction techniques and assess the fidelity of each reconstruction results by means of structured illumination and phase conjugation. By reconstructing the 3D refrac ...

EPFL2022

Pixel super-resolution with spatially entangled photons

Edoardo Charbon, Jiuxuan Zhao

Pixelation is common in quantum imaging systems and limit the image spatial resolution. Here, the authors introduce a pixel super-resolution approach based on measuring the full spatially-resolved joint probability distribution of spatially-entangled photo ...

Nature Portfolio2022

Event-driven acquisition for content-enriched microscopy

Suliana Manley, Dora Mahecic, Juliette Griffie, Chen Zhang, Martin Weigert, Willi Leopold Stepp

Event-driven acquisition uses neural-network-based recognition of specific biological events to trigger switching between slow and fast super-resolution imaging, enriching the capture of interesting events with high spatiotemporal resolution. A common goal ...

2022

Experimental demonstration of dynamic spatiotemporal structured beams that simultaneously exhibit two orbital angular momenta by combining multiple frequency lines, each carrying multiple Laguerre-Gaussian modes

Tobias Kippenberg, Hao Song, Maxim Karpov, Zhe Zhao, Xinzhou Su

In general, there are different, relatively independent forms of orbital angular momenta at a given propagation distance, which might exhibit different dynamic spatial characteristics. One type involves a beam with a helical phase-front that rotates around ...

Optica Publishing Group2022

The new X-ray/visible microscopy MAXWELL technique for fast three-dimensional nanoimaging with isotropic resolution

Giorgio Margaritondo, Lin Yang

Microscopy by Achromatic X-rays With Emission of Laminar Light (MAXWELL) is a new X-ray/visible technique with attractive characteristics including isotropic resolution in all directions, large-volume imaging and high throughput. An ultrathin, laminar X-ra ...

Nature Portfolio2022

Generation of OAM-carrying space-time wave packets with time-dependent beam radii using a coherent combination of multiple LG modes on multiple frequencies

Tobias Kippenberg, Hao Song, Maxim Karpov, Zhe Zhao, Xinzhou Su

Space-time (ST) wave packets, in which spatial and temporal characteristics are coupled, have gained attention due to their unique propagation characteristics, such as propagation invariance and tunable group velocity in addition to their potential ability ...

Optica Publishing Group2022

Optical Diffraction Tomography Using Nearly In-Line Holography with a Broadband LED Source

Demetri Psaltis, Ahmed Ayoub, Abhijit Roy

We present optical tomography methods for a 3D refractive index reconstruction of weakly scattering objects using LED light sources. We are able to record holograms by minimizing the optical path difference between the signal and reference beams while sepa ...

MDPI2022

Optical microscopy gets down to angstroms

Suliana Manley, Giorgio Tortarolo

Super-resolution microscopy at angstrom precision could pave the way to optical structural biology in cells. ...

NATURE PORTFOLIO2022

Ultrafast Transverse Modulation of Free Electrons by Interaction with Shaped Optical Fields

Thomas La Grange, Fabrizio Carbone, Ivan Madan, Giovanni Maria Vanacore, Francesco Barantani, Ido Kaminer, Alexey Sapozhnik, Simone Gargiulo, Veronica Leccese, Phoebe Marie Tengdin

Spatiotemporal electron-beam shaping is a bold frontier of electron microscopy. Over the past decade, shaping methods evolved from static phase plates to low-speed electrostatic and magnetostatic displays. Recently, a swift change of paradigm utilizing lig ...

AMER CHEMICAL SOC2022

Structured light generation by refractive-diffractive micro optical array illuminators

Maryam Yousefi

Structured light generation having broad applications in different optical fields, is the topic of this thesis. Our structured light generation strategy is based on applying periodic microoptical elements at the refraction-diffraction limit, under a focuse ...

EPFL2021

Spectral self-imaging of optical orbital angular momentum modes

Yin Chen, Camille Sophie Brès, Jianqi Hu, Yujie Chen

The Talbot self-imaging effect is mostly present in the forms of space or time, or in the frequency domain by the Fourier duality. Here, we disclose a new spectral Talbot effect arising in optical orbital angular momentum (OAM) modes. The effect occurs in ...

AIP Publishing2021

Biophysical applications of correlative scanning probe and super-resolution microscopy

Vytautas Navikas

Imaging live cells in their native environment is crucial for the understanding of complex biological phenomena. Modern optical microscopy methods such as fluorescence super-resolution microscopy are increasingly combined with complementary, label-free tec ...

EPFL2021

Towards quantum 3D imaging devices

Claudio Bruschini, Edoardo Charbon, Samuel Burri, Arin Can Ülkü, Paul Mos, Michael Alan Wayne

We introduce a new generation of 3D imaging devices based on quantum plenoptic imaging. Position-momentum entanglement and photon number correlations are exploited to provide a scan-free 3D image after post-processing of the collected light intensity signa ...

2021

Structured light engineering using a photonic nanojet

Toralf Scharf, Maryam Yousefi, Daniel Necesal

In this Letter, we present the photonic nanojet as a phenomenon in a structured light generator system that is implemented to modify the source focal spot size and emission angle. The optical system comprises a microlens array that is illuminated by a focu ...

OPTICAL SOC AMER2021

Versatile shaping of optical frequency combs and applications

Jianqi Hu

Optical frequency combs are a series of phase-locked and equidistant laser lines in the spectral domain. In the time domain, they correspond to periodic pulse trains by the Fourier relation. The ability to shape optical combs and pulse trains is pivotal to ...

EPFL2021