Publication

A Compressible Scaffold for Minimally Invasive Delivery of Large Intact Neuronal Networks

Publications associées (23)

Mesoscopic description of hippocampal replay and metastability in spiking neural networks with short-term plasticity

Bottom-up models of functionally relevant patterns of neural activity provide an explicit link between neuronal dynamics and computation. A prime example of functional activity patterns are propagating bursts of place-cell activities called hippocampal rep ...

PUBLIC LIBRARY SCIENCE2022

Leaking Secrets Through Compressed Caches

Daniel Felipe Forero Sanchez

We offer the first security analysis of cache compression, a promising architectural technique that is likely to appear in future mainstream processors. We find that cache compression has novel security implications because the compressibility of a cache l ...

IEEE COMPUTER SOC2021

Soft materials and technologies for neural interfaces

Michael Shur

Implantable neural interfaces are an emerging concept which is revolutionizing various domains of medicine and rehabilitation. However, the long-term efficiency and reliability of these devices is often limited, mainly attributed to the fundamental differe ...

EPFL2021

CTCF loss has limited effects on global genome architecture in Drosophila despite critical regulatory functions

Christian Iseli, Nicolas Jean Philippe Guex, Julien Dorier, Flavia Marzetta

Vertebrate genomes are partitioned into contact domains defined by enhanced internal contact frequency and formed by two principal mechanisms: compartmentalization of transcriptionally active and inactive domains, and stalling of chromosomal loop-extruding ...

Nature Research2021

A Simple Mechanistic Model for Friction of Rough Partially Lubricated Surfaces

Jean-François Molinari, Julie Richard, Tobias Brink, Gianluca Costagliola

We report experimental measurements of friction between an aluminum alloy sliding over steel with various lubricant densities. Using the topography scans of the surfaces as input, we calculate the real contact area using the boundary element method and the ...

2021

T cell force-responsive delivery of anticancer drugs using mesoporous silica microparticles

Li Tang, Kewen Lei

T cell-based cancer immunotherapy has achieved great success in the clinic; however, only a small fraction of patients respond to this therapy. Strategies to specifically and safely augment anticancer activity through controlled delivery of T cell supporti ...

2020

Soft microfabricated neural implants: a path towards translational implementation

Nicolas Vachicouras

Neuroprosthetics are a class of medical devices that aim to restore lost or impaired functions of the nervous system by electrical stimulation or recording of neural tissue. State of the art neural implants suffer today from a mechanical mismatch compared ...

EPFL2019

Two-photon triggered photorelease of caged compounds from multifunctional harmonic nanoparticles

Sandrine Gerber, Luigi Bonacina, Daniel Ortiz Trujillo, Laure Menin, Raphaël Jovita De Matos, Jérémy Vuilleumier

The design of stimuli-responsive nanocarriers has raised much attention to achieve higher local concentration of therapeutics and mitigate the appearance of drug resistance. The combination of imaging properties and controlled photorelease of active molecu ...

2019

Near-Optimal Noisy Group Testing via Separate Decoding of Items

Volkan Cevher, Jonathan Mark Scarlett

In this paper, we revisit an efficient algorithm for noisy group testing in which each item is decoded separately (Malyutov and Mateev, 1980), and develop novel performance guarantees via an information-theoretic framework for general noise models. For the ...

IEEE2018

Depth-dependent mechanical properties of human articular cartilage obtained by indentation measurements

Pierre-Etienne Bourban, Lee Ann Laurent-Applegate, Matteo Gregorio Modesto Marascio, Jens Antons, Robin Martin

Emerging 3D printing technology permits innovative approaches to manufacture cartilage scaffolds associated with layer-by-layer mechanical property adaptation. However, information about gradients of mechanical properties in human articular cartilage is li ...

2018

The small RNA RyhB is a regulator of cytochrome expression in Shewanella oneidensis

Rizlan Bernier-Latmani, Karin Lederballe Meibom

Shewanella oneidensis produces an extensive electron transfer network that results in metabolic flexibility. A large number of c-type cytochromes are expressed by S. oneidensis and these function as the fundamental electron transport chain proteins. Althou ...

Frontiers Media SA2018

Near-Optimal Noisy Group Testing via Separate Decoding of Items

Volkan Cevher, Jonathan Mark Scarlett

The group testing problem consists of determining a small set of defective items from a larger set of items based on a number of tests, and is relevant in applications such as medical testing, communication protocols, pattern matching, and more. In this pa ...

2018

Learning Neural Connectivity from Firing Activity: Scalable Algorithms with Provable Guarantees

Martin Vetterli, Amin Karbasi, Amir Hesam Salavati

The connectivity of a neuronal network has a major effect on its functionality and role. It is generally believed that the complex network structure of the brain provides a physiological basis for information processing. Therefore, identifying the network’ ...

Springer New York LLC2018

Correlation electron cyclotron emission diagnostic in TCV

Laurie Porte

The correlation electron cyclotron emission diagnostic of tokamak a configuration variable has recently been upgraded. It now has the choice of three lines of sight: two horizontal lines placed on the low field side of the vessel, perpendicular to the magn ...

2017

An in-situ synchrotron study on microplastic flow of electrodeposited nanocrystalline nickel

Helena Van Swygenhoven, Steven Van Petegem

Deformation in nanocrystalline (NC) materials is strongly influenced by the presence of a large fraction of grain boundaries. We present a comparative study on the role of intragranular root-mean-square strain and crystal-lographic texture on recovery proc ...

Elsevier Science Sa2017

Cell lineage tracing in human tissues using somatic mitochondrial mutations

Paul Refinetti

Lineage tracing is a basic concept in developmental biology, as well as diseases related to organ development. A reliable method to track cell lineages in human tissues has the potential to greatly contribute to the fields of oncogenesis, tissue renewal, a ...

EPFL2017

Computational development of the nanoporous materials genome

Berend Smit, Yongjin Lee, Peter George Boyd

There is currently a push towards big data and data mining in materials research to accelerate discovery. Zeolites, metal-organic frameworks and other related crystalline porous materials are not immune to this phenomenon, as evidenced by the proliferation ...

Nature Publishing Group2017

Resilience To Contagion In Financial Networks

Léo Hamed Amini

We derive rigorous asymptotic results for the magnitude of contagion in a large counterparty network and give an analytical expression for the asymptotic fraction of defaults, in terms of network characteristics. Our results extend previous studies on cont ...

Wiley-Blackwell2016

Computation and Visualization in Multiscale Modelling of DNA Mechanics

Jaroslaw Glowacki

Amongst the substances found in any living organism one of the most central in the workings of each living cell is deoxyribonucleic acid (DNA). For that reason it has been the subject of research in many of its aspects. These range from DNA sequencing to a ...

EPFL2016

Excitation of Sodium Atoms Attached to Helium Nanodroplets: The 3p

Marcel Drabbels, Evgeniy Loginov, Alberto Hernando de Castro

The dynamics of Na atoms on the surface of helium nanodroplets following excitation via the 3p

American Chemical Society2015