Publication

The Angiotensin-Converting Enzyme 2/Angiotensin-(1-7)/Mas receptor axis: A potential target for treating thrombotic diseases

Publications associées (29)

Real-time binding kinetics of ligand-receptor interactions : development and application of a label-free optical biosensor for living bacteria

In principle, a major goal in drug development is to design a high-affinity compound with an appropriate pharmacological response, which requires understanding of physical processes underlying the drug-target interaction, affinity and specificity. This dru ...

EPFL2017

Update on the role of angiotensin in the pathophysiology of coronary atherothrombosis

Nikolaos Stergiopoulos, Rodrigo Araujo Fraga Da Silva

BackgroundCoronary atherothrombosis due to atherosclerotic plaque rupture or erosion is frequently associated with acute coronary syndromes (ACS). Significant efforts have been made to elucidate the pathophysiological mechanisms underlying acute coronary e ...

Wiley-Blackwell2015

Antihypertensive drugs metabolism: an update to pharmacokinetic profiles and computational approaches

Ljubisa Miskovic, Vassily Hatzimanikatis, Aikaterini Zisaki

Drug discovery and development is a high-risk enterprise that requires significant investments in capital, time and scientific expertise. The studies of xenobiotic metabolism remain as one of the main topics in the research and development of drugs, cosmet ...

Bentham Science Publishers2015

Diminazene Protects Corpus Cavernosum Against Hypercholesterolemia-Induced Injury

Nikolaos Stergiopoulos, Rafaela Fernandes Da Silva, Younouss Faye, Mikaël Nils Sturny, Fabiana Pereira Da Costa Fraga

IntroductionAngiotensin-converting enzyme 2 (ACE2) is a key enzyme of the renin angiotensin system, which breaks down angiotensin II and forms angiotensin-(1-7). In erectile tissues, it has been documented that angiotensin II contributes to the development ...

Wiley-Blackwell2015

Hemodynamic transition driven by stent porosity in sidewall aneurysms

Mohamed Farhat, Pierre Bouillot

The healing process of intracranial aneurysms (IAs) treated with flow diverter stents (FDSs) depends on the IA flow modifications and on the epithelization process over the neck. In sidewall IA models with straight parent artery, two main hemodynamic regim ...

Elsevier2015

Treatment with Angiotensin-(1-7) reduces inflammation in carotid atherosclerotic plaques

Nikolaos Stergiopoulos, Rafaela Fernandes Da Silva, Luciano Dos Santos Aggum Capettini, Fabiana Pereira Da Costa Fraga, Katia Galan

Angiotensin (Ang)-(1-7), acting through the receptor Mas, has athero-protective effects; however, its role on plaque vulnerability has been poorly studied. Here, we investigated the expression of the renin-angiotensin system (RAS) components in stable and ...

Schattauer2014

Living-Engineered Valves for Transcatheter Venous Valve Repair

Peter Modregger, Marco Stampanoni

Background: Chronic venous insufficiency (CVI) represents a major global health problem with increasing prevalence and morbidity. CVI is due to an incompetence of the venous valves, which causes venous reflux and distal venous hypertension. Several studies ...

2014

Assessing the essentiality of the decaprenyl-phospho-D-arabinofuranose pathway in Mycobacterium tuberculosis using conditional mutants

Gaëlle Séraphine Kolly, John McKinney, Stewart Cole, Neeraj Dhar, Claudia Sala, Ruben Hartkoorn

In Mycobacterium tuberculosis the decaprenyl-phospho-d-arabinofuranose (DPA) pathway is a validated target for the drugs ethambutol and benzothiazinones. To identify other potential drug targets in the pathway, we generated conditional knock-down mutants o ...

Wiley-Blackwell2014

Mathematical and Numerical Modeling of Healthy and Unhealthy Cerebral Arterial Tissues

Paolo Tricerri

Over the last two decades, we have witnessed an increasing application of mathematical models and numerical simulations for the study of the cardiovascular system. Indeed, both tools provide an important contribution to the analysis of the functioning of t ...

EPFL2014