Optimizing dissolution dynamic nuclear polarization

This article is a short review of some of our recent developments in dissolution dynamic nuclear polarization (d-DNP). We present the basic principles of d-DNP, and motivate our choice to step away from conventional approaches. We then introduce a modified d-DNP recipe that can be summed up as follows: (i) Using broad line polarizing agents to efficiently polarize H-1 spins. (ii) Increasing the magnetic field to 6.7 T and above. (iii) Applying microwave frequency modulation. (iv) Applying H-1-C-13 cross polarization. (v) Transferring hyperpolarized solution through a magnetic tunnel. (C) 2015 Elsevier Inc. All rights reserved.