Publications associées à Measures of spatiotemporal organization differentiate persistent from long-standing atrial fibrillation

Implementation of an epicardial implantable MEMS sensor for continuous and real-time postoperative assessment of left ventricular activity in adult minipigs over a short- and long-term period

The sensing of left ventricular (LV) activity is fundamental in the diagnosis and monitoring of cardiovascular health in high-risk patients after cardiac surgery to achieve better short- and long-term outcome. Conventional approaches rely on noninvasive me ...

Aip Publishing2024

A comprehensive stroke risk assessment by combining atrial computational fluid dynamics simulations and functional patient data

Alfio Quarteroni

Stroke, a major global health concern often rooted in cardiac dynamics, demands precise risk evaluation for targeted intervention. Current risk models, like the CHA 2 DS 2 -VASc \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepa ...

Nature Portfolio2024

The role of computational methods in cardiovascular medicine: a narrative review

Alfio Quarteroni, Luca Dede', Christian Vergara, Stefano Pagani

Background and Objective: Computational models of the cardiovascular system allow for a detailed and quantitative investigation of both physiological and pathological conditions, thanks to their ability to combine clinical-possibly patient-specific-data wi ...

Ame Publishing Company2024

Finding information-rich electrocardiographic biomarkers to characterize atrial fibrillation

Anna Mary Mc Cann

Atrial fibrillation (AF) is the most common cardiac arrhythmia; it will affect one in four adults worldwide in their lifetime. AF has serious consequences, including drastically increased risk of stroke. Catheter ablation surgery is an established treatmen ...

EPFL2023

A comprehensive mathematical model for cardiac perfusion

Alfio Quarteroni, Christian Vergara, Francesco Regazzoni

The aim of this paper is to introduce a new mathematical model that simulates myocardial blood perfusion that accounts for multiscale and multiphysics features. Our model incorporates cardiac electrophysiology, active and passive mechanics, hemodynamics, v ...

Nature Portfolio2023

Single-arm diagnostic electrocardiography with printed graphene on wearable textiles

Ata Jedari Golparvar

Stimulated by the COVID-19 outbreak, the global healthcare industry better acknowledges the necessity of innovating novel methods for remote healthcare monitoring and treating patients outside clinics. Here we report the development of two different types ...

ELSEVIER SCIENCE SA2023

The Impact of Left Ventricular Performance and Afterload on the Evaluation of Aortic Valve Stenosis: A 1D Mathematical Modeling Approach

Nikolaos Stergiopoulos

The transaortic valvular pressure gradient (TPG) plays a central role in decision-making for patients suffering from severe aortic stenosis. However, the flow-dependence nature of the TPG makes the diagnosis of aortic stenosis challenging since the markers ...

MDPI2023

Left cardiac vagotomy rapidly reduces contralateral cardiac vagal electrical activity in anesthetized Gottingen minipigs

Silvestro Micera, Ivo Strauss

Background: The impact of acute unilateral injury on spontaneous electrical activity in both vagus nerves at the heart level is poorly understood. We investigated the immediate neuroelectrical response after right or left cardiac vagal nerve transection (V ...

Elsevier Ireland Ltd2023

A single-beat algorithm to discriminate farfield from nearfield bipolar voltage electrograms from the pulmonary veins

Vincent Schlageter, Jean-Marc Vesin, Adrian Luca

Background Superimposition of farfield (FF) and nearfield (NF) bipolar voltage electrograms (BVE) complicates the confirmation of pulmonary vein (PV) isolation after catheter ablation of atrial fibrillation. Our aim was to develop an automatic algorithm ba ...

SPRINGER2023

Hemodynamic effects of a dielectric elastomer augmented aorta on aortic wave intensity: An in-vivo study

Yves Perriard, Yoan René Cyrille Civet, Silje Ekroll Jahren, Thomas Guillaume Martinez, Francesco Clavica, Armando Matthieu Walter, Lorenzo Ferrari

Dielectric elastomer actuator augmented aorta (DEA) represents a novel approach with high potential for assisting a failing heart. The soft tubular device replaces a section of the aorta and increases its diameter when activated. The hemodynamic interactio ...

2023

Efficient approximation of cardiac mechanics through reduced-order modeling with deep learning-based operator approximation

Alfio Quarteroni, Andrea Manzoni

Reducing the computational time required by high-fidelity, full-order models (FOMs) for the solution of problems in cardiac mechanics is crucial to allow the translation of patient-specific simulations into clinical practice. Indeed, while FOMs, such as th ...

Wiley2023

Effect of the structural modification of Candesartan with Zinc on hypertension and left ventricular hypertrophy

Nikolaos Stergiopoulos, Augusto Martins Lima, Valeria Romina Martinez

Hypertension is the most common cause of left ventricular hypertrophy, contributing to heart failure progression. Candesartan (Cand) is an angiotensin receptor antagonist widely used for hypertension treatment. Structural modifications were previously perf ...

ELSEVIER2023

Correlation between conduction velocity and frequency analysis in patients with atrial fibrillation using high-density charge mapping

Lam Dang, Jean-Marc Vesin

Spectral analysis of atrial signals has been used to identify regions of interest in atrial fibrillation (AF). However, the relationship to the atrial substrate is unclear. In this study, we compare regions with dominant frequency (DF), simultaneously dete ...

SPRINGER HEIDELBERG2022

Novel spatiotemporal processing tools for body-surface potential map signals for the prediction of catheter ablation outcome in persistent atrial fibrillation

Jean-Marc Vesin, Etienne Pruvot, Adrian Luca

Background: Signal processing tools are required to efficiently analyze data collected in body-surface-potential map (BSPM) recordings. A limited number of such tools exist for studying persistent atrial fibrillation (persAF). We propose two novel, spatiot ...

FRONTIERS MEDIA SA2022

Evaluation and optimization of novel extraction algorithms for the automatic detection of atrial activations recorded within the pulmonary veins during atrial fibrillation

Jean-Marc Vesin, Yann Prudat, Etienne Pruvot, Sasan Yazdani, Adrian Luca

Background and objective The automated detection of atrial activations (AAs) recorded from intracardiac electrograms (IEGMs) during atrial fibrillation (AF) is challenging considering their various amplitudes, morphologies and cycle length. Activation time ...

BMC2022

Active force generation contributes to the complexity of spontaneous activity and to the response to stretch of murine cardiomyocyte cultures

Stéphanie Lacour

Cardiomyocyte cultures exhibit spontaneous electrical and contractile activity, as in a natural cardiac pacemaker. In such preparations, beat rate variability exhibits features similar to those of heart rate variability in vivo. Mechanical deformations and ...

WILEY2022

Impact of atrial fibrillation on left atrium haemodynamics: A computational fluid dynamics study

Alfio Quarteroni, Luca Dede'

We analyse the haemodynamics of the left atrium, highlighting differences between healthy individuals and patients affected by atrial fibrillation. The computational study is based on patient-specific geometries of the left atria to simulate blood flow dyn ...

PERGAMON-ELSEVIER SCIENCE LTD2022

Cardiovascular monitoring system

Marco Mattavelli, Catherine Dehollain, Diego Ruben Barrettino, Kerim Türe, Mustafa Besirli

A cardiovascular monitoring system for measuring at least cardiac output comprises an implantable unit (2) configured for placement in a section of artery of a patient and a portable external unit (1) configured for mounting against or close to a patient's ...

2022

Arterial Wave Reflection and Aortic Valve Stenosis: Diagnostic Challenges and Prognostic Significance

Nikolaos Stergiopoulos, Stamatia Zoi Pagoulatou, Vasiliki Bikia, Georgios Rovas

IntroductionArterial wave reflection is an important component of the left ventricular afterload, affecting both pressure and flow to the aorta. The aim of the present study was to evaluate the impact of wave reflection on transvalvular pressure gradients ...

FRONTIERS MEDIA SA2022

Mitochondrial Creatine Kinase Attenuates Pathologic Remodeling in Heart Failure

Annina Stuber, Yi Zhang, Ashish Gupta

BACKGROUND: Abnormalities in cardiac energy metabolism occur in heart failure (HF) and contribute to contractile dysfunction, but their role, if any, in HF-related pathologic remodeling is much less established. CK (creatine kinase), the primary muscle ene ...

LIPPINCOTT WILLIAMS & WILKINS2022