Publication

Cerebrospinal fluid hydrodynamics in type I Chiari malformation

Publications associées (17)

Large-scale in-silico analysis of CSF dynamics within the subarachnoid space of the optic nerve

BackgroundImpaired cerebrospinal fluid (CSF) dynamics is involved in the pathophysiology of neurodegenerative diseases of the central nervous system and the optic nerve (ON), including Alzheimer's and Parkinson's disease, as well as frontotemporal dementia ...

BMC2024

Automated Analysis of Cerebrospinal Fluid Flow and Motile Cilia Properties in The Central Canal of Zebrafish Embryos

François Gallaire, Ludovic Pierre Gustave Keiser

Circulation of cerebrospinal fluid (CSF) plays an important role during development. In zebrafish embryo, the flow of CSF has been found to be bidirectional in the central canal of the spinal cord. In order to compare conditions and genetic mutants across ...

BIO-PROTOCOL2021

A rare condition: Spontaneous subarachnoid haemorrhage due to spinal hemangioblastoma: Report of 2 cases and review of the literature

Constantin Tuleasca

Introduction. - Subarachnoid haemorrhage (SAH), secondary to spinal hemangioblastoma (HBL), is extremely rare, with only a few case reports to date. We report the experience of our reference centre for spinal tumours and Von Hippel-Lindau (VHL) disease in ...

2020

Soft multimodal neural interfaces for unravelling sensory neurological circuits

Frédéric Pierre Gérald Michoud

Diseases or injuries affecting the nervous system can dramatically disrupt the quality of life. Despite extensive efforts towards treating dysfunctional nervous systems, the pharmacological and electrical approaches generally involved lack the temporal and ...

EPFL2019

Advantages of soft subdural implants for the delivery of electrochemical neuromodulation therapies to the spinal cord

Jérôme Gandar, Stéphanie Lacour, Grégoire Courtine, Nikolaus Wenger, Ivan Rusev Minev, Eduardo Martin Moraud, Pavel Musienko, Marco Capogrosso, Polina Shkorbatova, Nathan Antoine Greiner

Objective. We recently developed soft neural interfaces enabling the delivery of electrical and chemical stimulation to the spinal cord. These stimulations restored locomotion in animal models of paralysis. Soft interfaces can be placed either below or abo ...

2018

Inter-operator Reliability of Magnetic Resonance Image-Based Computational Fluid Dynamics Prediction of Cerebrospinal Fluid Motion in the Cervical Spine

Nikolaos Stergiopoulos, Bryn Andrew Martin

For the first time, inter-operator dependence of MRI based computational fluid dynamics (CFD) modeling of cerebrospinal fluid (CSF) in the cervical spinal subarachnoid space (SSS) is evaluated. In vivo MRI flow measurements and anatomy MRI images were obta ...

Springer2016

Characterization of the Discrepancies Between Four-Dimensional Phase-Contrast Magnetic Resonance Imaging and In-Silico Simulations of Cerebrospinal Fluid Dynamics

Bryn Andrew Martin

The purpose of the present study was to compare subject-specific magnetic resonance imaging (MRI)-based computational fluid dynamics (CFD) simulations with time-resolved three-directional (3D) velocity-encoded phase-contrast MRI (4D PCMRI) measurements of ...

American Society of Mechanical Engineers2015

The Impact of Spinal Cord Nerve Roots and Denticulate Ligaments on Cerebrospinal Fluid Dynamics in the Cervical Spine

Bryn Andrew Martin

Cerebrospinal fluid (CSF) dynamics in the spinal subarachnoid space (SSS) have been thought to play an important pathophysiological role in syringomyelia, Chiari I malformation (CM), and a role in intrathecal drug delivery. Yet, the impact that fine anatom ...

Public Library of Science2014

Ferritin H gene deletion in the choroid plexus and forebrain results in hydrocephalus

Patrick Fraering, Claude André Schweizer

Ferritin H, the major iron storage protein, has essential functions in early embryonic development as well as in adult liver and intestine. To address the question whether ferritin H has similarly essential functions in the brain we used the Cre/loxP syste ...

Elsevier2014

A coupled hydrodynamic model of the cardiovascular and cerebrospinal fluid system

Nikolaos Stergiopoulos, Philippe Reymond, Bryn Andrew Martin

Martin BA, Reymond P, Novy J, Baledent O, Stergiopulos N. A coupled hydrodynamic model of the cardiovascular and cerebrospinal fluid system. Am J Physiol Heart Circ Physiol 302: H1492-H1509, 2012. First published January 20, 2012; doi: 10.1152/ajpheart.006 ...

2012

Comparison of 4D Phase-Contrast MRI Flow Measurements to Computational Fluid Dynamics Simulations of Cerebrospinal Fluid Motion in the Cervical Spine

Nikolaos Stergiopoulos, Bryn Andrew Martin

Cerebrospinal fluid (CSF) dynamics in the cervical spinal subarachnoid space (SSS) have been thought to be important to help diagnose and assess craniospinal disorders such as Chiari I malformation (CM). In this study we obtained time-resolved three direct ...

Public Library Science2012

Magnetic resonance 4D flow analysis of cerebrospinal fluid dynamics in Chiari I malformation with and without syringomyelia

Bryn Andrew Martin

To analyse cerebrospinal fluid (CSF) hydrodynamics in patients with Chiari type I malformation (CM) with and without syringomyelia using 4D magnetic resonance (MR) phase contrast (PC) flow imaging. 4D-PC CSF flow data were acquired in 20 patients with CM ( ...

Springer2012

Bio Simulation of Brain Ventricle Dilation in Normal Pressure Hydrocephalus

Kamal Shahim

Hydrocephalus is a brain disease wherein the ventricles dilate and compress the parenchyma towards the skull. It is primarily characterized by the disruption of the cerebrospinal fluid (CSF) flow within the ventricular system. Normal pressure hydrocephalus ...

EPFL2011

Calculation of intracranial pressure in human brain using Darcy's and Biot's models

Jean-Marie Drezet, Kamal Shahim

Cerebrospinal fluid (CSF) is a colourless liquid that fills the ventricular space and serves several functions like buoyancy, chemical stability and protection. CSF is produced within the ventricles and partly by the ependyma cells. Part of it seeps toward ...

Taylor & Francis2011

Spinal Subarachnoid Space Pressure Measurements in an In Vitro Spinal Stenosis Model: Implications on Syringomyelia Theories

Bryn Andrew Martin

Full explanation for the pathogenesis of syringomyelia (SM), a neuropathology characterized by the formation of a cystic cavity (syrinx) in the spinal cord (SC), has not yet been provided. It has been hypothesized that abnormal cerebrospinal fluid (CSF) pr ...

2010

Fluid mechanics of intrathecal drug delivery

Radboud Michael Nelissen

The aim of this principally experimental study is to understand from fluid mechanic principles why an insignificant anesthetic dose administered as a short bolus into the cerebrospinal fluid inside the subarachnoid space provides greater pain relief than a ...

EPFL2008

Optimization of the treatment of hydrocephalus by the non-invasive measurement of the intra-cranial pressure

Alec Ginggen

This thesis work aims to optimize the treatment of hydrocephalus. It consists of two distinct objectives: the optimization of the diagnosis of patients implanted with a shunt system for the derivation of cerebro-spinal fluid (CSF) and the optimization of t ...

EPFL2007