Publications associées à The Mind Behind the Hebbian Synapse Donald O Hebb

Non-invasive stimulation of the human striatum disrupts reinforcement learning of motor skills

Elena Beanato, Esra Neufeld, Friedhelm Christoph Hummel, Takuya Morishita, Maximilian Jonas Wessel, Traian Popa, Pierre Theopistos Vassiliadis, Julie Duqué, Fabienne Windel

Reinforcement feedback can improve motor learning, but the underlying brain mechanisms remain underexplored. In particular, the causal contribution of specific patterns of oscillatory activity within the human striatum is unknown. To address this question, ...

Nature Portfolio2024

Learnable latent embeddings for joint behavioural and neural analysis

Mackenzie Mathis, Steffen Schneider, Jin Hwa Lee

Mapping behavioural actions to neural activity is a fundamental goal of neuroscience. As our ability to record large neural and behavioural data increases, there is growing interest in modelling neural dynamics during adaptive behaviours to probe neural re ...

NATURE PORTFOLIO2023

Assemblies, synapse clustering and network topology interact with plasticity to explain structure-function relationships of the cortical connectome

James Gonzalo King, Eilif Benjamin Muller, Michael Reimann, Marwan Muhammad Ahmed Abdellah, Giuseppe Chindemi, Pramod Shivaji Kumbhar, András Ecker, Daniela Egas Santander, Ioannis Magkanaris, Sirio Bolaños Puchet, Jorge Blanco Alonso, James Bryden Isbister

Synaptic plasticity underlies the brain’s ability to learn and adapt. While experiments in brain slices have revealed mechanisms and protocols for the induction of plasticity between pairs of neurons, how these synaptic changes are coordinated in biologica ...

2024

Principles of Network Plasticity in Neocortical Microcircuits

András Ecker

Synaptic plasticity underlies our ability to learn and adapt to the constantly changing environment. The phenomenon of synapses changing their efficacy in an activity-dependent manner is often studied in small groups of neurons in vitro or indirectly throu ...

EPFL2023

A theory of memory consolidation and synaptic pruning in cortical circuits

Georgios Iatropoulos

Over the course of a lifetime, the human brain acquires an astonishing amount of semantic knowledge and autobiographical memories, often with an imprinting strong enough to allow detailed information to be recalled many years after the initial learning exp ...

EPFL2023

Perceived impacts of the Fridays for Future climate movement on environmental concern and behaviour in Switzerland

Claudia Rebeca Binder Signer, Livia Bianca Fritz, Ralph Hansmann

Calling for increased action on climate change, Fridays for Future (FFF) quickly gained momentum around the world and became highly visible through strikes and protests in more than 150 countries. Considering its scale and magnitude, questions about the im ...

2023

Engram cell connectivity as a mechanism for information encoding and memory function

Maurizio Ferdinando Pezzoli

Information derived from experiences is incorporated into the brain as changes to ensembles of cells, termed engram cells, which allow memory storage and recall. The mechanism by which those changes hold specific information is unclear. Here, we test the h ...

Cell Press2023

Plasticity of sensory representations in the posterior insular cortex during fear learning

Denys Osypenko

Aversively-motivated associative learning allows animals to avoid harm and thus ensures survival. Aversive learning can be studied by the fear learning paradigm, in which an innocuous sensory stimulus like a tone (conditioned stimulus, CS), acquires a nega ...

EPFL2023

Lactate supply overtakes glucose when neural computational and cognitive loads scale up

Pierre Magistretti

Neural computational power is determined by neuroenergetics, but how and which energy substrates are allocated to various forms of memory engram is unclear. To solve this question, we asked whether neuronal fueling by glucose or lactate scales differently ...

National Academy of Sciences2022

Methods for acute and long-term imaging of the ventral nerve cord in behaving adult Drosophila

Laura Joan Hermans

Understanding how neural circuits remodel and adapt to animal behavior is a central theme in the field of Neuroscience. One strategy to reach this goal is to repeatedly record the same animal's neural circuits and observe how they adapt when facing differe ...

EPFL2022

Mesoscopic description of hippocampal replay and metastability in spiking neural networks with short-term plasticity

Valentin Marc Schmutz, Tilo Schwalger

Bottom-up models of functionally relevant patterns of neural activity provide an explicit link between neuronal dynamics and computation. A prime example of functional activity patterns are propagating bursts of place-cell activities called hippocampal rep ...

PUBLIC LIBRARY SCIENCE2022

Depotentiation of associative plasticity is intact in Parkinson's disease with mild dyskinesia

Traian Popa

Objective: Depotentiation of homosynaptic plasticity of the primary motor cortex (M1) is impaired in patients with Parkinson's disease (PD) who have developed dyskinesias. In this exploratory study, we tested whether this holds true for heterosynaptic plas ...

ELSEVIER SCI LTD2022

Do Children Adapt Their Perspective to a Robot When They Fail to Complete a Task?

Pierre Dillenbourg, Ana Paiva, Elmira Yadollahi

Spatial understanding and communication are essential skills in human interaction. An adequate understanding of others' spatial perspectives can increase the quality of the interaction, both perceptually and cognitively. In this paper, we take the first st ...

Assoc Computing Machinery2022

Orchestration of oscillatory activity to improve visual motion discrimination

Roberto Felipe Salamanca Giron

This thesis describes advances in the use of novel configurations of non-invasive brain stimulation over the visual system allowing to modulate of modifying electro-physiological activity, interregional interactions and by it, visual behavior such as motio ...

EPFL2021

Homeostatic regulation of axonal Kv1.1 channels accounts for both synaptic and intrinsic modifications in the hippocampal CA3 circuit

Mickael Maurice Zbili

Homeostatic plasticity of intrinsic excitability goes hand in hand with homeostatic plasticity of synaptic transmission. However, the mechanisms linking the two forms of homeostatic regulation have not been identified so far. Using electrophysiological, im ...

National Academy of Sciences2021

Development and application of dynamic functional connectivity methods to elucidate the neural underpinnings of human behaviour with functional magnetic resonance imaging

Thomas William Arthur Bolton

Human behaviour is exquisitely complex, because it is staggeringly multi-facetted and subtly varies across individuals. Characterising its yet incompletely understood underlying biological mechanisms has profound clinical implications. Here, our goal was t ...

EPFL2020

Measurement-system design for structural identification

Numa Joy Bertola

In developed countries, the management of existing civil infrastructure is challenging due to evolving functional requirements, aging and climate change. Due to conservative approaches in construction design and practice, infrastructure often has hidden re ...

EPFL2020

A numerical study on the coupled hydro-mechanical behaviour of compacted bentonite

Lyesse Laloui, Alessio Ferrari, Jose Antonio Bosch Llufriu

Understanding the mechanical behaviour of compacted bentonite upon re-saturation is of outmost importance in most designs of nuclear waste disposal repositories. The behaviour of bentonite is characterized by its stress-path dependency and it is typically ...

EDP SCIENCES2020

LPA1 receptor and chronic stress: Effects on behaviour and the genes involved in the hippocampal excitatory/inhibitory balance

Maria del Carmen Sandi Perez, Olivia Zanoletti, Alexandre Claude Gustave Bacq, Roman Moreno Fernandez

The LPA1 receptor, one of the six characterized G protein-coupled receptors (LPA1–6) through which lysophosphatidic acid acts, is likely involved in promoting normal emotional behaviours. Current data suggest that the LPA-LPA1-receptor pathway may be invol ...

2020

Dendritic Voltage Recordings Explain Paradoxical Synaptic Plasticity: A Modeling Study

Wulfram Gerstner, Claire Meissner-Bernard, Matthias Chinyen Tsai, Laureline Logiaco

Experiments have shown that the same stimulation pattern that causes Long-Term Potentiation in proximal synapses, will induce Long-Term Depression in distal ones. In order to understand these, and other, surprising observations we use a phenomenological mo ...

FRONTIERS RESEARCH FOUNDATION2020