Publication

Reversible protonation of a thiolate ligand in an [Fe]-hydrogenase model complex

Publications associées (24)

Copper(ii) complexes with tridentate halogen-substituted Schiff base ligands: synthesis, crystal structures and investigating the effect of halogenation, leaving groups and ligand flexibility on antiproliferative activities

To investigate the effect of different halogen substituents and leaving groups and the flexibility of ligands on the anticancer activity of copper complexes, sixteen copper(ii) complexes with eight different tridentate Schiff-base ligands containing pyridi ...

ROYAL SOC CHEMISTRY2021

High-Valent Nickel Promoted by Atomically Embedded Copper for Efficient Water Oxidation

Jun Li, Bo Zhang, Yun Liu, Ning Wang

Efficient and low-cost electrocatalysts for oxygen evolution reaction (OER), particularly in neutral conditions, are of significant importance for renewable energy technologies such as CO2 reduction and seawater splitting electrolysis. High-valent transiti ...

AMER CHEMICAL SOC2020

The atomic-resolution crystal structure of activated [Fe]-hydrogenase

Matthew Wodrich, Xile Hu

Hydrogenases are promising templates for constructing new H-2-based catalysts. [Fe]-hydrogenase, which features an ironguanylylpyridinol (FeGP) cofactor, catalyses a reversible hydride transfer from H-2 to methenyl-tetrahydromethanopterin (methenyl-H4MPT+, ...

NATURE PUBLISHING GROUP2019

A catalytically active [Mn]-hydrogenase incorporating a non-native metal cofactor

Matthew Wodrich, Xile Hu, Farzaneh Fadaei Tirani, Huijie Pan

Nature carefully selects specific metal ions for incorporation into the enzymes that catalyse the chemical reactions necessary for life. Hydrogenases, enzymes that activate molecular H-2, exclusively utilize Ni and Fe in [NiFe]-, [FeFe]- and [Fe]-hydrogean ...

2019

A Functional Model of [Fe]-Hydrogenase

Rosario Scopelliti, Matthew Wodrich, Xile Hu, Simona Mazza, Tao Xu

[Fe]-Hydrogenase catalyzes the hydrogenation of a biological substrate via the heterolytic splitting of molecular hydrogen. While many synthetic models of [Fe]-hydrogenase have been prepared, none yet are capable of activating H-2 on their own. Here, we re ...

American Chemical Society2016

Fe N-Heterocyclic Carbene Complexes as Promising Photosensitizers

Yizhu Liu

The photophysics and photochemistry of transition metal complexes (TMCs) has long been a hot field of interdisciplinary research. Rich metal-based redox processes, together with a high variety in electronic configurations and excited-state dynamics, have r ...

Amer Chemical Soc2016

Reconstitution of [Fe]-hydrogenase using model complexes

Matthew Wodrich, Xile Hu, Dafa Chen, Tao Xu

[Fe]-Hydrogenase catalyses the reversible hydrogenation of a methenyltetrahydromethanopterin substrate, which is an intermediate step during the methanogenesis from CO2 and H-2. The active site contains an iron-guanylylpyridinol cofactor, in which Fe2+ is ...

Nature Publishing Group2015

Iron Complexes for Hydrogen Activation and Catalytic Hydrogenation

Simona Mazza

Inspired by Nature several groups have developed structural and functional iron complexes mimicking the active site of the iron-hydrogenases, which show high reactivity in the H2 cleavage. Usually pendant bases have been incorporated onto families of Fe co ...

EPFL2015

Synthesis and Reactivity of Mononuclear Iron Models of [Fe]-Hydrogenase that Contain an Acylmethylpyridinol Ligand

Xile Hu, Dafa Chen, Bowen Hu

[Fe]-hydrogenase has a single iron-containing active site that features an acylmethylpyridinol ligand. This unique ligand environment had yet to be reproduced in synthetic models; however the synthesis and reactivity of a new class of small molecule mimics ...

Wiley-V C H Verlag Gmbh2014

(Arene)ruthenium Complexes with Imidazolin-2-imine and Imidazolidin-2-imine Ligands

Kay Severin, Rosario Scopelliti, Justus Tönnemann

Imidazolin-2-imine and imidazolidin-2-imine ligands are versatile N donors in transition metal chemistry. Here, we describe the synthesis and characterization of (arene)Ru complexes with these ligands. Simple adducts of the type [(p-cymene)Ru(L)Cl-2] (L = ...

Wiley-Blackwell2014

Electronic Elements Governing the Binding of Small Molecules to a [Fe]-hydrogenase Mimic

Matthew Wodrich, Xile Hu

[Fe]-hydrogenase, one of three types of hydrogenases, activates molecular hydrogen. Here, using DFT computations, we examine the electronic elements governing the binding of small ligands to a recently synthesized [Fe]-hydrogenase biomimic. Computed reacti ...

Wiley-Blackwell2013

Analysis of copper-ligand bond lengths in X-ray structures of different types of copper sites in proteins

Luciano Andres Abriata

An updated picture of the ligand sets and copper-ligand atom bond lengths in proteins is presented which takes advantage of (i) the approximately twofold increase in the number of entries for copper-containing proteins in the PDB since the last study of th ...

Wiley-Blackwell2012

X-ray absorption spectroscopy studies of the adducts formed between cytotoxic gold compounds and two major serum proteins

Angela Casini

Gold metallodrugs form a class of promising antiproliferative agents showing a high propensity to react with proteins. We exploit here X-ray absorption spectroscopy (XAS) methods [both X-ray absorption near-edge spectroscopy (XANES) and extended X-ray abso ...

Springer Verlag2011

A Five-Coordinate Iron Center in the Active Site of [Fe]-Hydrogenase: Hints from a Model Study

Rosario Scopelliti, Xile Hu, Dafa Chen

The synthesis, structure, and reactivity of a five-coordinate model complex of [Fe]-hydrogenase are described. The work suggests that the iron center in [Fe]-hydrogenases could be five-coordinate in the resting state. ...

Wiley-VCH Verlag GmbH2011

An Iron Carbonyl Pyridonate Complex Related to the Active Site of the [Fe]-Hydrogenase (Hmd)

Rosario Scopelliti, Blaise Valentin Obrist, Xile Hu, Dafa Chen

A mononuclear iron bis(carbonyl) pyridonate complex (1), which exhibits several common structural features with the active site of the iron−sulfur cluster-free [Fe]- hydrogenase, was synthesized and characterized. Spectroscopic data of 1 suggests a 2+ oxid ...

2009

Carbohydrate-metal complexes and their potential as anticancer agents

Paul Joseph Dyson, Christian Hartinger, Alexey Nazarov

A review. Platinum complex-based chemotherapy is one of the major treatment options of many malignancies. Although severe side effects occur, and only a limited spectrum of tumors can be cured, Pt compds. are used in every second therapy scheme. Thus, many ...

2008

Acetonitrile exchange kinetics on di- and trivalent lanthanide ions

Gabriella Eva Bodizs

The knowledge and understanding of the mechanism as well as the rate constant of the solvent exchange reactions are fundamental, since these reactions represent an important step in complex formation reactions on metal ions. Solvent exchange reactions in a ...

EPFL2008

Crystal and Electronic Structures of Magnesium(II), Copper(II), and Mixed Magnesium(II)−Copper(II) Complexes of the Quinoline Half of Styrylquinoline-Type HIV-1 Integrase Inhibitors

Philip Pattison

A new target in AIDS therapy development is HIV-1 integrase (IN). It was proven that HIV-1 IN required divalent metal cations to achieve phosphodiester bond cleavage of DNA. Accordingly, all newly investigated potent IN inhibitors contain chemical fragment ...

2007

Novel strategies for overcoming drug resistance in transition metal-based anticancer compounds

Wee Han Ang

Cisplatin is one of the most important and widely used anticancer drug in clinical use. However, its effectiveness is limited by its high toxicity and incidence of drug resistance. This has provided motivation for the search for transition metal-based drug ...

EPFL2007

New polynuclear catalysts for atom-transfer radical addition reactions

Laurent Quebatte

Homo- and heterobimetallic complexes of the late transitions metals have been synthesized by metathesis reactions of the corresponding chloro-bridged dimers. These reactions have the advantage of being fast and giving rise to structurally defined products ...

EPFL2006