Publications associées à Simultaneous Multi-Harmonic Imaging of Nanoparticles in Tissues for Increased Selectivity

Nonlinear Frequency Conversion in III-Nitride Doubly Resonant Photonic Crystal Cavities

Nonlinear frequency conversion processes, such as second-harmonic generation (SHG) and spontaneous parametric down-conversion (SPDC), are essential in many applications, including the generation of entangled photons. It's desirable to enhance these process ...

EPFL2023

Hyperthermic intrathoracic chemotherapy to control malignant pleural mesothelioma

Yameng Hao

OBJECTIVE: Malignant pleural mesothelioma (MPM) is a rare disease that has a poor response to conventional therapy. Hyperthermic intrathoracic chemotherapy (HITOC), a treatment combining fever-range hyperthermia with intrapleural cisplatin chemotherapy, ha ...

EPFL2023

Tunable photo-induced second-harmonic generation in a mode-engineered silicon nitride microresonator

Camille Sophie Brès, Jianqi Hu, Anton Stroganov, Edgars Nitiss, Boris Zabelich

All-optical poling enables reconfigurable and efficient quasi-phase-matching for second-order parametric frequency conversion in silicon nitride integrated photonics. Here, we report broadly tunable milliwatt-level second-harmonic generation in a small fre ...

2023

A chip-scale second-harmonic source via self-injection-locked all-optical poling

Tobias Kippenberg, Camille Sophie Brès, Junqiu Liu, Edgars Nitiss, Marco Clementi

Second-harmonic generation allows for coherently bridging distant regions of the optical spectrum, with applications ranging from laser technology to self-referencing of frequency combs. However, accessing the nonlinear response of a medium typically requi ...

2023

KRAB zinc finger proteins link heterochromatin maintenance to replicative stress and inflammation in diffuse large B-cell lymphoma

Filipe Amândio Brandão Sanches Vong Martins

Genomic instability enhances cancer progression by favoring clonal diversity, yet uncontrolled replicative stress can lead to mitotic catastrophe and inflammatory responses promoting immune rejection. KRAB-containing zinc finger proteins (KZFPs) are epigen ...

EPFL2023

Pan-cancer atlas of somatic core and linker histone mutations

Sebastian Martin Waszak

Recent genomic data points to a growing role for somatic mutations altering core histone and linker histone-encoding genes in cancer. However, the prevalence and the clinical and biological implications of histone gene mutations in malignant tumors remain ...

2023

A Structured Dictionary Perspective on Implicit Neural Representations

Pascal Frossard, Beril Besbinar, Guillermo Ortiz Jimenez, Gizem Yüce

Implicit neural representations (INRs) have recently emerged as a promising alternative to classical discretized representations of signals. Nevertheless, despite their practical success, we still do not understand how INRs represent signals. We propose a ...

IEEE COMPUTER SOC2022

Slice Estimation in Diffusion MRI of Neonatal and Fetal Brains in Image and Spherical Harmonics Domains Using Autoencoders

Meritxell Bach Cuadra, Hamza Kebiri, Gabriel Girard, Erick Jorge Canales Rodriguez, Thomas Yu

Diffusion MRI (dMRI) of the developing brain can provide valuable insights into the white matter development. However, slice thickness in fetal dMRI is typically high (i.e., 3-5 mm) to freeze the in-plane motion, which reduces the sensitivity of the dMRI s ...

SPRINGER INTERNATIONAL PUBLISHING AG2022

Harmonic decomposition of the trace of 1D transfer matrices in layered media

Antonio Joaquin Garcia Suarez

The Transfer Matrix formalism is ubiquitous when it comes to study wave propagation in various stratified media, applications ranging from Seismology to Quantum Mechanics. A relation between variables at two points in two different layers can be establishe ...

2022

Modelling of AC/DC Interactions of Converter-Interfaced Resources for Harmonic Power-Flow Studies in Microgrids

Mario Paolone, Andreas Martin Kettner, Johanna Kristin Maria Becker, Yihui Zuo

Modern power distribution systems experience a large-scale integration of Converter-Interfaced Distributed Energy Resources (CIDERs). As acknowledged by recent literature, the interaction of individual CIDER components and different CIDERs through the grid ...

2022

Gd3+-Functionalized Lithium Niobate Nanoparticles for Dual Multiphoton and Magnetic Resonance Bioimaging

Sandrine Gerber, Anne-Sophie Chauvin, Luigi Bonacina, Marinella Mazzanti, Katarzyna Pierzchala, Raphaël Jovita De Matos, Dario Diviani, Jérémy Vuilleumier, Adrian Stefan Gheata, Ileana Ozana Jelescu, Laura Camille Louise Nicolle, Fiorella Lucarini

Harmonic nanoparticles (HNPs) have emerged as appealing exogenous probes for optical bioimaging due to their distinctive features such as long-term photostability and spectral flexibility, allowing multiphoton excitation in the classical (NIR-I) and extend ...

2022

Optically reconfigurable quasi-phase-matching in silicon nitride microresonators

Camille Sophie Brès, Jianqi Hu, Anton Stroganov, Edgars Nitiss

Quasi-phase-matching has long been a widely used approach in nonlinear photonics, enabling efficient parametric frequency conversions such as second-harmonic generation. However, in silicon photonics the task remains challenging, as materials best suited f ...

Nature Publishing Group2022

Biodegradable Harmonophores for Targeted High-Resolution In Vivo Tumor Imaging

Sylvie Roke, Ali Yasin Sonay, Shahed Behzadi, Claire Jacqueline Léa Teulon, Sine Yaganoglu

Optical imaging probes have played a major role in detecting and monitoring a variety of diseases. In particular, nonlinear optical imaging probes, such as second harmonic generating (SHG) nanoprobes, hold great promise as clinical contrast agents, as they ...

2021

Cancer Cells Retrace a Stepwise Differentiation Program during Malignant Progression

Douglas Hanahan, Krisztian Homicsko, Stephan Wullschleger, Mohammad Sadegh Saghafinia, Iacovos Michael, Giovanni Ciriello

Pancreatic neuroendocrine tumors (PanNET) comprise two molecular subtypes, relatively benign islet tumors (IT) and invasive, metastasis-like primary (MLP) tumors. Until now, the origin of aggressive MLP tumors has been obscure. Herein, using multi-omics ap ...

AMER ASSOC CANCER RESEARCH2021

Seeded Multimode Quasi-Phase-Matching in All-Optically Poled Silicon Nitride Waveguides

Camille Sophie Brès, Edgars Nitiss, Ozan Yakar

We demonstrate seeding-enabled all-optical poling of silicon nitride waveguides as short as 5 mm, and account for quasi-phase-matching (QPM) inside the waveguide between the fundamental mode of pump and higher order second-harmonic modes. ...

OSA2021

Metabolic and transcriptomic profiles of glioblastoma invasion revealed by comparisons between patients and corresponding orthotopic xenografts in mice

Lijing Xin, Cristina Ramona Cudalbu, Mario Gaetano Lepore, Marta Lai

The invasive behavior of glioblastoma, the most aggressive primary brain tumor, is considered highly relevant for tumor recurrence. However, the invasion zone is difficult to visualize by Magnetic Resonance Imaging (MRI) and is protected by the blood brain ...

2021

Discovering Tonal Profiles with Latent Dirichlet Allocation

Martin Alois Rohrmeier, Fabian Claude Moss

Music analysis, in particular harmonic analysis, is concerned with the way pitches are organized in pieces of music, and a range of empirical applications have been developed, for example, for chord recognition or key finding. Naturally, these approaches r ...

2021

Open-access quantitative MRI data of the spinal cord and reproducibility across participants, sites and manufacturers

Dimitri Nestor Alice Van De Ville, Christian Büchel, Nawal Noëlle Kinany, Maryam Seif, Maxime Descoteaux

In a companion paper by Cohen-Adad et al. we introduce the spine generic quantitative MRI protocol that provides valuable metrics for assessing spinal cord macrostructural and microstructural integrity. This protocol was used to acquire a single subject da ...

NATURE PORTFOLIO2021

Doubly resonant second-harmonic generation of a vortex beam from a bound state in the continuum

Jean-François Carlin, Romuald Houdré, Nicolas Grandjean, Matteo Galli, Momchil Minkov, Jun Wang, Marco Clementi

Second-harmonic generation in nonlinear materials can be greatly enhanced by realizing doubly resonant cavities with high quality factors. However, fulfilling such doubly resonant condition in photonic crystal (PhC) slab cavities is a long-standing challen ...

2020

Metabolic plasticity and glucose transporter redundancy dictate lung adenocarcinoma growth

Caroline Anne-Lyse Contat

Lung cancers represent the leading cause of cancer-related deaths worldwide. These pulmonary cancers count several histological subgroups, whose non-small cell lung cancers, subject of our study. We were precisely interested in the most common subtype of n ...

EPFL2020