Publications associées à Architecture Internalisation in BIP

The autism susceptibility kinase, TAOK2, phosphorylates eEF2 and modulates translation

Genes implicated in translation control have been associated with autism spectrum disorders (ASDs). However, some important genetic causes of autism, including the 16p11.2 microdeletion, bear no obvious connection to translation. Here, we use proteomics, g ...

Amer Assoc Advancement Science2024

Opportunities, Challenges, and Pitfalls in Making, Characterizing, and Understanding Polymer Brushes

Harm-Anton Klok

Polymer brushes have been theoretically described, their behavior under diverse conditions has been modeled, and their preparation via surface-initiated polymerizations (SIPs) has been progressively refined. However, despite three decades of research endea ...

American Chemical Society2023

Transformer Models for Vision

Jean-Baptiste Francis Marie Juliette Cordonnier

The recent developments of deep learning cover a wide variety of tasks such as image classification, text translation, playing go, and folding proteins. All these successful methods depend on a gradient-based learning algorithm to train a model on massive ...

EPFL2023

Dense Image-based Predictions for Comics Analysis

Deblina Bhattacharjee

Dense image-based prediction methods have advanced tremendously in recent years. Their remarkable development has been possible due to the ample availability of real-world imagery. While these methods work well on photographs, their abilities do not genera ...

EPFL2023

Elastocapillary menisci mediate interaction of neighboring structures at the surface of a compliant solid

John Martin Kolinski

Surface stress drives long-range elastocapillary interactions at the surface of compliant solids, where it has been observed to mediate interparticle interactions and to alter the transport of liquid drops. We show that such an elastocapillary interaction ...

2023

Type-Preserving Compilation of Class-Based Languages

Guillaume André Fradji Martres

The Dependent Object Type (DOT) calculus was designed to put Scala on a sound basis, but while DOT relies on structural subtyping, Scala is a fundamentally class-based language. This impedance mismatch means that a proof of DOT soundness by itself is ...

EPFL2023

Biochemistry of Aminoacyl tRNA Synthetase and tRNAs and Their Engineering for Cell-Free and Synthetic Cell Applications

Sebastian Maerkl, Ragunathan Bava Ganesh

Cell-free biology is increasingly utilized for engineering biological systems, incorporating novel functionality, and circumventing many of the complications associated with cells. The central dogma describes the information flow in biology consisting of t ...

FRONTIERS MEDIA SA2022

A Rapid Translational Immune Response Program in CD8 Memory T Lymphocytes

Linlin Cao

The activation of memory T cells is a very rapid and concerted cellular response that requires coordination between cellular processes in different compartments and on different time scales. In this study, we use ribosome profiling and deep RNA sequencing ...

American Association of Immunologists ; Oxford University Press2022

Scaling Language Features for Program Verification

Georg Stefan Schmid

Formal verification of real-world software systems remains challenging for a number of reasons, including lack of automation, friction in specifying properties, and limited support for the diverse programming paradigms used in industry. In this thesis we m ...

EPFL2022

V-ATPase/TORC1-mediated ATFS-1 translation directs mitochondrial UPR activation in C. elegans

Felix Naef, Kristina Schoonjans, Johan Auwerx, Hao Li, Yang Li, Wen Gao, Xiaoxu Li, Amélia Lalou, Nagammal Neelagandan, Jia Liu, Yuan Liu

To adapt mitochondrial function to the ever-changing intra- and extracellular environment, multiple mitochondrial stress response (MSR) pathways, including the mitochondrial unfolded protein response (UPRmt), have evolved. However, how the mitochondrial st ...

Rockefeller University Press2022

Overcoming decision paralysis—A digital twin for decision making in energy system design

François Maréchal, Tuong-Van Nguyen, Julia Granacher

The design of efficient energy systems, through the development of new technologies and the improvement of current ones, requires the use of rigorous process synthesis methods for generating and analysing design alternatives. We introduce a digital twin of ...

2022

Type-Level Programming with Match Types

Martin Odersky, Olivier Eric Paul Blanvillain

Type-level programming is becoming more and more popular in the realm of functional programming. However, the combination of type-level programming and subtyping remains largely unexplored in practical programming languages. This paper presents match types ...

ASSOC COMPUTING MACHINERY2022

Unleashing Parallelism in Elastic Circuits with Faster Token Delivery

Paolo Ienne, Lana Josipovic, Andrea Guerrieri, Ayatallah Ahmed Gamal Kamal Elakhras

High-level synthesis (HLS) is the process of automatically generating circuits out of high-level language descriptions. Previous research has shown that dynamically scheduled HLS through elastic circuit generation is successful at exploiting parallelism in ...

IEEE COMPUTER SOC2022

Automated Verification of Network Function Binaries

George Candea, Aikaterini Argyraki, Solal Vincenzo Pirelli

Formally verifying the correctness of software network functions (NFs) is necessary for network reliability, yet existing techniques require full source code and mandate the use of specific data structures. We describe an automated technique to verify NF b ...

USENIX Association2022

On the ‘cultural transfer’ of modern architecture northwards - Akzeptiere: Das Buch und seine Geschichte

Chiara Monterumisi

"Akzeptiere: Das Buch und seine Geschichte" is the latest in-depth contribution by Atli Magnus Seelow, one of several by him on the 1930 Stockholm exhibition and the book accepetera, the 200-page text often referred to as ‘the manifesto of Swedish function ...

2021

Organic semiconductors for light-mediated neuromodulation

Diego Ghezzi, Danashi Imani Medagoda

There is growing interest in organic semiconductor devices for light-mediated neuromodulation, such as for retinal stimulation. Here, the key working principles of these devices are discussed, as well as promising applications and outstanding challenges fo ...

SPRINGERNATURE2021

Discourse Phenomena in Machine Translation

Lesly Sadiht Miculicich Werlen

Machine Translation (MT) has made considerable progress in the past two decades, particularly after the introduction of neural network models (NMT). During this time, the research community has mostly focused on modeling and evaluating MT systems at the se ...

EPFL2021

Enclosure: Language-Based Restriction of Untrusted Libraries

Adrien Ghosn, Edouard Bugnion, James Richard Larus, Evangelos Marios Kogias, Mathias Josef Payer

Programming languages and systems have failed to address the security implications of the increasingly frequent use of public libraries to construct modern software. Most languages provide tools and online repositories to publish, import, and use libraries ...

ACM2021

Towards an artificial cell: Development of a system which self-regenerates the protein components of the PURE system in microfluidic reactors

Barbora Lavickova

Thanks to recent advancements in synthetic biology, the dream of creating a synthetic cell has become feasible. However, due to its inherent complexity, one of the fundamental functions of all living systems, i.e., self-replication, remains to be introduce ...

EPFL2021

System for planning and/or providing neuromodulation

Vincent Delattre, Grégoire Courtine, Marco Capogrosso, Fabien Bertrand Paul Wagner, Karen Minassian

The present invention relates to systems and methods for planning and/or providing neuromodulation One example system includesa stimulation related basic data storage module for storing stimulation related basic data,a stimulation related response data sto ...

2021