Publications related to Freeze drying

Revealing the Structure of Tryptophan in Microhydrated Complexes by Cold Ion Spectroscopy

Natalia Nagornova, Oleg Boyarkine, Andrei Zviagin, Ruslan Yamaletdinov, Manuel Dömer

The geometry of biomolecules isolated in the gas phaseusuallydiffers substantially from their native structures in aqueous solution,which are the only ones truly relevant to life science. To connectthe high resolution of cold ion spectroscopy that can be a ...

2023

Hemoglobin-stabilized gold nanoclusters displaying oxygen transport ability, self-antioxidation, auto-fluorescence properties and long-term storage potential

Victor Carle Adrien Boureau

The development of hemoglobin (Hb)-based oxygen carriers (HBOCs) holds a lot of potential to overcome important drawbacks of donor blood such as a short shelf life or the potential risk of infection. However, a crucial limitation of current HBOCs is the au ...

ROYAL SOC CHEMISTRY2023

Controlling the crystal structure of succinic acid via microfluidic spray-drying

Esther Amstad, Aysu Ceren Okur

Many properties of materials, including their dissolution kinetics, hardness, and optical appearance, depend on their structure. Unfortunately, it is often difficult to control the structure of low molecular weight organic compounds that have a high propen ...

ROYAL SOC CHEMISTRY2023

Fabrication of micrometer-sized drops as templates for particles

Mathias Steinacher

Drops are omnipresent in our daily life for example in the form of rain drops or as oil drops in a salad dressing. On a technological basis, drops can be used to conduct chemical or biological reactions. These drops often serve as templates to produce mate ...

EPFL2021

Device and process for tissue-engineering and regenerative medicine

Olaia Maria Naveiras Torres-Quiroga, Thomas Michael Braschler, Amélie Barbara Hildegarde Béduer, Josefine Catharina Pedersen Tratwal, Daniel Naveed Tavakol, Martina Genta

A process and device for direct in-vitro to in-vivo transfer of a living microcarrier culture by controlled dehydration into a viscoelastic material capable of cell-protection during delivery. One particular purpose of the present invention is that of prov ...

2021

Microfluidics and cell-free synthetic biology in the development of new diagnostic and therapeutic platforms

Grégoire Michielin

In phenylketonuria, absence or malfunction of the phenylalanine hydroxylase enzyme results in toxic accumulation of phenylalanine in the body. An injectable recombinant enzyme therapy was recently approved and has the potential to improve the quality of li ...

EPFL2021

Evolution of microstructural changes in cement paste during environmental drying

Karen Scrivener, Fabien Jacques Michel Georget, Hamed Maraghechi, Wioletta Soja

Exposure of concrete to the atmosphere changes the microstructure of the cement paste. However, knowledge about the alteration of the porosity due to drying is typically not considered in deterioration processes of the hardened cement paste. The purpose of ...

Pergamon-Elsevier Science Ltd2020

Energy efficient hydrogen drying and purification for fuel cell vehicles

Hubert Girault, Heron Vrubel, Yorick Ligen

High-purity standards are required for hydrogen used in fuel cell vehicles. The relative abundance of contaminants is highly influenced by the production pathway. Hydrogen obtained from water electrolysis presents three main pollutants: Nitrogen, Oxygen an ...

Elsevier2020

Reusability of filtering facepiece respirators after decontamination through drying and germicidal UV irradiation

Véronique Michaud, David Vernez, Guillaume Suarez, Kiattisak Batsungnoen

Introduction During pandemics, such as the SARS-CoV-2, filtering facepiece respirators plays an essential role in protecting healthcare personnel. The recycling of respirators is possible in case of critical shortage, but it raises the question of the effe ...

2020

Production of Additive‐Free Amorphous Nanoparticles with a SAW‐Based Microfluidic Spray‐Dryer

Esther Amstad, Huachuan Du, Mathias Steinacher, Duncan Christophe Emmanuel Gilbert

Spray‐drying is a widely employed, cost‐effective process to formulate solutions into solid particles of controlled sizes and compositions. In addition, this process can also offer control over the structure of spray‐dried particles: if the solvent is evap ...

Wiley2019

Cell-free soil bio-cementation with strength, dilatancy and fabric characterization

Lyesse Laloui, Dimitrios Terzis

A multi-disciplinary approach is adopted in the present work towards investigating bio-cemented geo-materials which extends from sample preparation, to microstructural inspection and mechanical behaviour characterization. We suggest a new way to induce “ce ...

2019

Thin Hydrogel-Elastomer Multilayer Encapsulation for Soft Electronics

Stéphanie Lacour, Aaron Powers Gerratt, Jennifer Mary Adrienne Alice Macron

In the exciting race to design and engineer biointegrated and body-like electronic systems, many efforts concentrate on the integration of hydrogels in electronic assemblies. The versatility of hydrogels chemistry combined with their tissue-mimicking prope ...

Wiley2019

3-D micro-architecture and mechanical response of soil cemented via microbial-induced calcite precipitation

Lyesse Laloui, Dimitrios Terzis

We introduce the application of microbial-induced calcite precipitation via the ureolytic soil bacterium Sporosarcina Pasteurii in freeze-dried form, as a means of enhancing overall MICP efficiency and reproducibility for geotechnical engineering applicati ...

Nature Research2018

Periodic cellular aluminum structures for space applications : from casting to additive manufacturing

Florian Thibaut Gallien

Mass is one of the crucial parameters for hardware that has to be placed in Earth orbit. Due to its harsh environment, a material with highest specific properties is desired to achieve space missions. The rise and development of new technologies, such as a ...

EPFL2018

Laboratory testing of gas shales in unsaturated conditions

Lyesse Laloui, Alessio Ferrari, Alberto Minardi

Water uptake of gas shales is commonly considered one of the most important factors responsible for fluid loss during flowback operations after hydraulic fracturing. Imbibition experiments cover a key role in this context to analyze the impact of several f ...

2018

The microfluidic nebulator: production of submicrometer sized airborne drops

Esther Amstad

Many powders employed in the food and pharmaceutical industries are produced through spray drying because it is a cost efficient process that offers control over the particle size. However, most commercially available spray-driers cannot produce drops with ...

Royal Soc Chemistry2017

Kinetics, Mechanics and Micro-structure of Bio-cemented Soils

Dimitrios Terzis

The quest for novel, performant materials and methods in the engineering practice is driven nowadays by the need to offer solutions to complex problems by coupling technical innovation with environmental responsibility. Such problems emerge in the geo-tech ...

EPFL2017

Online Detection of Selenium and Its Retention in Reducing Gasification Atmosphere

Christian Ludwig, Andrea Testino, Mohamed Tarik, Adrian Hess

The emission of selenium from coal gasification processes can cause harm to the environment and downstream equipment. With upcoming legislation, reliable detection as well as control of such gas species become crucial. This study therefore addresses the de ...

American Chemical Society2016

Surface 3D Micro Free Forms: Multifunctional Microstructured Mesoporous alpha-Alumina by in Situ Slip Casting Using Excimer Laser Ablated Polycarbonate Molds

Paul Bowen, Patrik Willi Hoffmann, Sriharitha Rowthu

Ceramic surface microstructuring is a rapidly growing field with a variety of applications in tribology, wetting, biology, and so on. However, there are limitations to large-area microstructuring and fabrication of three-dimensional (3D) micro free forms. ...

Amer Chemical Soc2015

Visualization of water drying in porous materials by X-ray phase contrast imaging

Anne Bonnin

We present in this study results from X-ray tomographic microscopy with synchrotron radiation performed both in attenuation and phase contrast modes on a limestone sample during two stages of water drying. No contrast agent was used in order to increase th ...

Wiley-Blackwell2015