Publications related to Oil immersion

van der Waals Materials for Overcoming Fundamental Limitations in Photonic Integrated Circuitry

With the advance of on-chip nanophotonics, there is a high demand for high-refractive-index and low-loss materials. Currently, this technology is dominated by silicon, but van der Waals (vdW) materials with a high refractive index can offer a very advanced ...

AMER CHEMICAL SOC2023

Nonlinear Inverse Problems in Quantitative Phase Imaging

Thanh-An Michel Pham

The topic of this thesis is the development of new algorithmic reconstruction methods for quantitative phase imaging (QPI). In the past decade, advanced QPI has emerged as a valuable tool to study label-free biological samples and uncover their 3D structur ...

EPFL2022

Advanced Techniques in Optical Diffraction Tomography

Ahmed Bassam Sayed Ayoub Mohamed Emam

In this thesis, we study the 3 challenges described above. First, we study different reconstruction techniques and assess the fidelity of each reconstruction results by means of structured illumination and phase conjugation. By reconstructing the 3D refrac ...

EPFL2022

Glass-in-glass infiltration for 3D micro-optical composite components

Andreas Mortensen, Yves Bellouard, Jérôme Faist, Gözden Torun, Enrico Casamenti, Luciano Borasi, Mathieu Bertrand

Chalcogenide glass exhibits a wide transmission window in the infrared range, a high refractive index, and nonlinear optical properties; however, due to its poor mechanical properties and low chemical and environmental stability, producing three-dimensiona ...

2022

Correction of spherical surface measurements by confocal microscopy

Toralf Scharf, Wilfried Noell, Jeremy Béguelin

Refractive microlenses are nowadays widely used in optical systems. Characterizing their surface is essential to ensure their quality and to optimize their fabrication process. This is realized by optical surface profilers thanks to their vertical resoluti ...

2020

Optical characterization of high numerical aperture microlenses for quality assessment and fabrication process optimization

Toralf Scharf, Wilfried Noell, Jeremy Béguelin

Accurate characterization of high numerical aperture aspheric microlenses currently is a nonstandard procedure that remains an open challenge. Here, we present and discuss a characterization method based on interferometric and point spread function measure ...

OPTICAL SOC AMER2020

Improving 3D MA-TIRF Reconstruction with Deconvolution and Background Estimation

Emmanuel Emilien Louis Soubies, Sébastien Schaub

Total internal reflection fluorescence microscopy (TIRF) produces 2D images of the fluorescent activity integrated over a very thin layer adjacent to the glass coverslip. By varying the illumination angle (multi-angle TIRF), a stack of 2D images is acquire ...

IEEE2019

Phase resolved characterization of nanoscale features in optical microstructures

Michail Symeonidis

In this study, we apply interferometric microscopy to study the phase, alongside the intensity, of the light field transmitted through a wide variety of samples. Additionally, we conduct those interferometric measurements at different wavelengths within th ...

EPFL2019

Integrated Gallium Phosphide Photonics

Katharina Schmeing

The integration of new materials mediating light-matter interaction in nanoscale devices is a persistent goal in nanophotonics. One of these materials is Gallium phosphide, which offers an attractive combination of a high refractive index (n=3.05 at a wave ...

EPFL2019

Dielectric-sphere-based microsystem for optical super-resolution imaging

Gergely Huszka

Well-established imaging techniques proved that features below the diffraction limit can be observed optically using so-called super-resolution microscopies, which overcome Abbe's resolution limit. In traditional far-field microscopy, the introduction of f ...

EPFL2018

Coherent imaging from bacteria to multicellular organisms

Séverine Coquoz

Structural and functional imaging of cells, tissues and organisms is crucial for understanding biomedical processes. Fluorescence microscopy is an established tool and has contributed to many discoveries in the life sciences. This technique provides molecu ...

EPFL2017

Advances in pancreatic islet monolayer culture on glass surfaces enable super-resolution microscopy and insights into beta cell ciliogenesis and proliferation

Jeffrey Alan Hubbell, Olivier Burri, Steinunn Baekkeskov Hanahan, Chiara Cianciaruso, Miriella Carmela Pasquier, Edward Allen Phelps, Andreas Wiederkehr, Gabriele Galliverti

A robust and reproducible method for culturing monolayers of adherent and well-spread primary islet cells on glass coverslips is required for detailed imaging studies by super-resolution and livecell microscopy. Guided by an observation that dispersed isle ...

Springer Nature2017

Microfluidic and Electrokinetic Manipulation of Single Cells

Samuel Kilchenmann

Traditional cell assays report on the average results of a cell population. However, a wide range of new tools are being developed for a fundamental understanding of single cell's functionality. Nonetheless, the current tools are either limited in their th ...

EPFL2017

Near-field characterization of Bloch surface waves based 2D optical components

Richa Dubey

Bloch surface waves (BSWs) are surface electromagnetic modes that propagate at the interface between a multilayer substrate and a homogeneous external medium. The optical field of the surface mode is confined near the surface of the multilayer. This vertic ...

EPFL2017

Interferometric synthetic aperture microscopy for extended focus optical coherence microscopy

Theo Lasser, Paul James Marchand, Arno Pino Bouwens, Jérôme Extermann, Séverine Coquoz

Optical coherence microscopy (OCM) is an interferometric technique providing 3D images of biological samples with micrometric resolution and penetration depth of several hundreds of micrometers. OCM differs from optical coherence tomography (OCT) in that i ...

2017

High-Q surface modes in photonic crystal/iron garnet film heterostructures for sensor applications

Giovanni Dietler, Serguei Sekatski, Pavel Kapralov

A novel type of a plasmonic sensor based on a magnetophotonic plasmonic heterostructure with an ultrahigh-Q resonance is considered. A magnetoplasmonic resonance with an angular width of 0.06A degrees, which corresponds to a Q factor of 700 and is a record ...

Springer Verlag2017

Design of a refractive surface

Mark Pauly, Yuliy Gennadievich Schwartzburg

Method of designing a refractive surface, comprising providing a refractive object having a refractive surface with an initial geometry, determining a refraction of incident illumination through the refractive surface with the initial geometry to create a ...

2017

Hybrid PDMS/glass microfluidics for high resolution imaging and application to sub-wavelength particle trapping

Romuald Houdré, Nicolas Maxime André Descharmes, Mario Lucien Henri Tonin

We demonstrate the fabrication of a hybrid PDMS/glass microfluidic layer that can be placed on top of non-transparent samples and allows high-resolution optical microscopy through it. The layer mimics a glass coverslip to limit optical aberrations and can ...

Royal Society of Chemistry2016

A Point-Spread-Function-Aware Filtered Backprojection Algorithm for Focal-Plane-Scanning Optical Projection Tomography

Michael Stefan Daniel Liebling

Traditional optical projection tomography requires the use of low numerical aperture objectives in order to achieve a large depth of field and approximate parallel projection geometry. However, low NA objectives suffer from poor resolution, resulting in bl ...

2016

Transition of optical regime in miniaturized optical systems: light interactions beyond the refraction limit

Hans Peter Herzig, Toralf Scharf, Myun Sik Kim

We investigate the transition of optical regimes of miniaturized optical systems using two canonical examples, where the refraction of light limits the system performance. A ball-lens and a solid immersion lens (SIL) are considered, whose refractive respon ...

Spie-Int Soc Optical Engineering2016