Publications related to Early human migrations

Bacterial diversity dominates variable macrophage responses of tuberculosis patients in Tanzania

The Mycobacterium tuberculosis complex (MTBC) comprises nine human-adapted lineages that differ in their geographical distribution. Local adaptation of specific MTBC genotypes to the respective human host population has been invoked in this context. We aim ...

Nature Portfolio2024

City, State, Transnational Space

Garance Clément

This chapter takes stock of contemporary migration by breaking with a few myths and by distinguishing between interregional and international migration. It shows how new research paradigms have relativized the importance of the state as the preferred frame ...

ISTE Wiley2023

Identifying genetic and dietary modulators of metabolic disorders using systems genetics

Xiaoxu Li

Long-term consumption of lipid-rich foods can contribute to common metabolic diseases and systemic low-grade inflammation. However, dietary responses and the development of non-communicable diseases are shaped by genetic factors and gene-by-environment int ...

EPFL2023

A platform for experimental precision medicine: The extended BXD mouse family

Johan Auwerx, Evan Graehl Williams

The challenge of precision medicine is to model complex interactions among DNA variants, phenotypes, development, environments, and treatments. We address this challenge by expanding the BXD family of mice to 140 fully isogenic strains, creating a uniquely ...

CELL PRESS2021

The Quest for Genes Involved in Adaptation to Climate Change in Ruminant Livestock

Stéphane Joost, Elia Vajana

Simple Summary: After domestication in specific regions, livestock followed human migrations and colonized the whole world. During this population expansion, human and natural selection, together with demographic events, molded the livestock genome leading ...

2021

Population Genomics of Mycobacterium leprae Reveals a New Genotype in Madagascar and the Comoros

Stewart Cole, Stefanie Boy-Röttger, Andrej Benjak, Charlotte Avanzi, Philippe Busso, Pushpendra Singh, Thyago Leal Calvo

Human settlement of Madagascar traces back to the beginning of the first millennium with the arrival of Austronesians from Southeast Asia, followed by migrations from Africa and the Middle East. Remains of these different cultural, genetic, and linguistic ...

Frontiers Media SA2020

Géohistoire de l'Albanie moderne. Une lecture des recensements de 1918 à 2011

Alain Nicolas Jarne

In this thesis, an original database is constituted, described and exploited in a geohistorical perspective, containing the registration of the population at the local level for the fifteen censuses conducted in Albania between 1918 and 2011. The precision ...

EPFL2020

Global maps of travel time to healthcare facilities

Kristina Gligoric

Access to healthcare is a requirement for human well-being that is constrained, in part, by the allocation of healthcare resources relative to the geographically dispersed human population(1-3). Quantifying access to care globally is challenging due to the ...

2020

The Demographic History of African Drosophila melanogaster

Jeffrey David Jensen, Adamantia Kapopoulou, Susanne Petra Pfeifer, Stefan Jean Laurent

As one of the most commonly utilized organisms in the study of local adaptation, an accurate characterization of the demographic history of Drosophila melanogaster remains as an important research question. This owes both to the inherent interest in charac ...

OXFORD UNIV PRESS2018

Genome-wide SNP profiling of worldwide goat populations reveals strong partitioning of diversity and highlights post-domestication migration routes

Stéphane Joost, Estelle Rochat, Elia Vajana

Background: Goat populations that are characterized within the AdaptMap project cover a large part of the worldwide distribution of this species and provide the opportunity to assess their diversity at a global scale. We analysed genome-wide 50K single nuc ...

BMC2018

An ecotoxicological view on neurotoxicity assessment

Wolfgang Schulz

The numbers of potential neurotoxicants in the environment are raising and pose a great risk for humans and the environment. Currently neurotoxicity assessment is mostly performed to predict and prevent harm to human populations. Despite all the efforts in ...

SPRINGEROPEN2018

Preface: Special Section on Energy and Food Security in a Humanitarian Context

Silvia Hostettler

Natural disasters, population growth, social conflicts, and political or structural crises give rise to forced migrations, which can lead to humanitarian emergencies. According to the “UNHCR annual global trends report”, 65.6 million people were displaced ...

2017

The climate of Europe during the Holocene: a gridded pollen-based reconstruction and its multi-proxy evaluation

Jed Oliver Kaplan, Basil Andrew Stansfield Davis, Pamela Collins, Achille Mauri

We present a new gridded climate reconstruction for Europe for the last 12,000 years based on pollen data. The reconstruction is an update of Davis et al. (2003) using the same methodology, but with a greatly expanded fossil and surface-sample dataset and ...

Pergamon-Elsevier Science Ltd2015

Metapopulation persistence and species spread in river networks

Andrea Rinaldo, Enrico Bertuzzo, Lorenzo Mari, Marino Gatto

River networks define ecological corridors characterised by unidirectional streamflow, which may impose downstream drift to aquatic organisms or affect their movement. Animals and plants manage to persist in riverine ecosystems, though, which in fact harbo ...

Wiley-Blackwell2014

Robust Demographic Inference from Genomic and SNP Data

Matthieu Foll

We introduce a flexible and robust simulation-based framework to infer demographic parameters from the site frequency spectrum (SFS) computed on large genomic datasets. We show that our composite-likelihood approach allows one to study evolutionary models ...

Public Library of Science2013

European genetic diversity and susceptibility to pathogens

Jacques Fellay, Amalio Telenti, Paul Jack Mc Laren

Infectious diseases, both in their endemic and epidemic forms, have shaped the human genome. Ecology has also contributed to geographically constrained pressures on human populations. There are now multiple examples of population-specific genetic variants ...

2013

Exploring potential drivers of European biomass burning over the Holocene: a data-model analysis

Jed Oliver Kaplan

AimTo reconstruct spatial and temporal patterns of European fire activity during the Holocene and to explore their potential drivers, by relating biomass burning to simulated biotic and abiotic parameters. LocationEurope. MethodsHolocene fire activity was ...

Wiley-Blackwell2013

Used planet: A global history

Jed Oliver Kaplan

Human use of land has transformed ecosystem pattern and process across most of the terrestrial biosphere, a global change often described as historically recent and potentially catastrophic for both humanity and the biosphere. Interdisciplinary paleoecolog ...

National Academy of Sciences2013

Have we underestimated the importance of humans in the biogeography of free-living terrestrial microorganisms?

The role of humans in the global dispersal of free-living terrestrial microorganisms has received surprisingly little attention in the literature, compared with the frequent discussions of human dispersal for aquatic microbes. Here I argue that this area n ...

2010

Genetic diversity in farm animals - a review

Domestication of livestock species and a long history of migrations, selection and adaptation have created an enormous variety of breeds. Conservation of these genetic resources relies on demographic characterization, recording of production environments a ...

Wiley-Blackwell2010