Publications related to Mind uploading

Minding Rights: Mapping Ethical and Legal Foundations of 'Neurorights'

The rise of neurotechnologies, especially in combination with artificial intelligence (AI)-based methods for brain data analytics, has given rise to concerns around the protection of mental privacy, mental integrity and cognitive liberty - often framed as ...

CAMBRIDGE UNIV PRESS2023

Data Transformation in the Processing of Neuronal Signals: A Powerful Tool to Illuminate Informative Contents

Mohammad Ali Shaeri

Neuroscientists seek efficient solutions for deciphering the sophisticated unknowns of the brain. Effective development of complicated brain-related tools is the focal point of research in neuroscience and neurotechnology. Thanks to today's technological a ...

2023

An optimized protocol for assessing changes in mouse whole-brain activity using opto-fMRI

Valerio Zerbi, Christina Maria Grimm

Functional magnetic resonance imaging (fMRI) in mouse brain, paired with spatially and temporally defined manipulations, offers a powerful tool to causally explain the effect of specific neuronal activity on brain network dynamics. Here, we present an opti ...

ELSEVIER2022

Computational Concepts for Reconstructing and Simulating Brain Tissue

Srikanth Ramaswamy, Felix Schürmann, Jean-Denis Georges Emile Courcol

It has previously been shown that it is possible to derive a new class of biophysically detailed brain tissue models when one computationally analyzes and exploits the interdependencies or the multi-modal and multi-scale organization of the brain. These re ...

Springer2022

Towards patient-tailored interventions for stroke recovery: graph theoretical approaches and modeling of non-invasive brain stimulation

Giorgia Giulia Evangelista

Stroke is a disease that causes the death of precious brain cells that will never grow back and which will affect one in four humans at some point in their life. While therapies and treatments for this debilitating condition are fairly standard, their outc ...

EPFL2022

Data-driven whole mouse brain modeling for multi-scale simulations

Dimitri Bruno Marie Rodarie

In this thesis, we present a data-driven iterative pipeline to generate, simulate and validate point-neuron models of the whole mouse brain. The ultimate goal is to replicate close loop experiments with a virtual body in a virtual world. This pipeline was ...

EPFL2022

Supplemental Data - Intact Drosophila Whole Brain Cellular Quantitation reveals Sexual Dimorphism

Brian Donal McCabe, Wei Jiao

Supplemental Figures, Datasets and Movies supporting the manuscript - Intact Drosophila Whole Brain Cellular Quantitation reveals Sexual Dimorphism. Wei Jiao, Gard Spreemann, Evelyne Ruchti, Soumya Banerjee, Ying Shi, R. Steven Stowers, Ka ...

Zenodo2021

Large-scale functional network dynamics in human callosal agenesis: Increased subcortical involvement and preserved laterality

Dimitri Nestor Alice Van De Ville, Anjali Bagunu Tarun, Vanessa Siffredi, Younes Farouj

In the human brain, the corpus callosum is the major white-matter commissural tract enabling the transmission of sensory-motor, and higher level cognitive information between homotopic regions of the two cerebral hemispheres. Despite developmental absence ...

ACADEMIC PRESS INC ELSEVIER SCIENCE2021

Analytic performance modeling and analysis of detailed neuron simulations

Felix Schürmann, Francesco Cremonesi, Gerhard Wellein

Big science initiatives are trying to reconstruct and model the brain by attempting to simulate brain tissue at larger scales and with increasingly more biological detail than previously thought possible. The exponential growth of parallel computer perform ...

2020

Dynamic spatiotemporal patterns of brain connectivity reorganize across development

Alessandra Griffa, Patric Hagmann, Marie Schaer, Emeline Mullier

Late human development is characterized by the maturation of high-level functional processes, which rely on reshaping of white matter connections, as well as synaptic density. However, the relationship between the whole-brain dynamics and the underlying wh ...

MIT PRESS2020

Understanding Computational Costs of Cellular-Level Brain Tissue Simulations Through Analytical Performance Models

Felix Schürmann, Francesco Cremonesi

Computational modeling and simulation have become essential tools in the quest to better understand the brain's makeup and to decipher the causal interrelations of its components. The breadth of biochemical and biophysical processes and structures in the b ...

HUMANA PRESS INC2020

A synchrotron X-ray imaging strategy to map large animal brains

Giorgio Margaritondo, Ying Chen

Mapping the large neural networks of animal and human brains is a fundamental but so far elusive task, because of the massive amount of data and the consequent prohibitively long image taking and processing times. We developed an effective strategy called ...

2020

The Scientific Case for Brain Simulations

Felix Schürmann, Michele Migliore, Alain Destexhe

A key element of the European Union's Human Brain Project (HBP) and other large-scale brain research projects is the simulation of large-scale model networks of neurons. Here, we argue why such simulations will likely be indispensable for bridging the scal ...

CELL PRESS2019

A null model of the mouse whole-neocortex micro-connectome

Henry Markram, Eilif Benjamin Muller, Michael Reimann, Ying Shi, Huanxiang Lu

In connectomics, the study of the network structure of connected neurons, great advances are being made on two different scales: that of macro- and meso-scale connectomics, studying the connectivity between populations of neurons, and that of micro-scale c ...

Nature Research2019

The Connection Between the Nervous System and Machines: Commentary

Giacomo Valle

Decades of technological developments have populated the field of brain-machine interfaces and neuroprosthetics with several replacement strategies, neural modulation treatments, and rehabilitation techniques to improve the quality of life for patients aff ...

2019

Computational characteristics and hardware implications of brain tissue simulations

Francesco Cremonesi

Understanding the link between the brain's anatomy and its function through computer simulations of neural tissue models is a widely used approach in computational neuroscience. This technique enables rapid prototyping and testing of hypotheses, allowing r ...

EPFL2019

Data-driven reconstruction of a point neuron mouse brain

Csaba Erö

In this work, we present a semi-automatic method to reconstruct a mouse whole-brain model at the point-neuron level by integrating a wide array of biological data. Our process has three parts: cell position and type assignment, connectivity mapping, and si ...

EPFL2018

Accelerating Data Analysis in Simulation Neuroscience with Big Data Technologies

Felix Schürmann, Judit Planas Carbonell, Fabien Jonathan Delalondre

Important progress in computational sciences has been made possible recently thanks to the increasing computing power of high performance systems. Following this trend, larger scientific studies, like brain tissue simulations, will continue to grow in the ...

Springer International Publishing2018

Neuroprosthetics to support impaired hand functions: A multidisciplinary approach combining brain-machine interfaces and wearable exoskeletons

Luca Randazzo

Neuroprosthetics, the discipline that aims at interfacing neural systems to artificially engineered devices, has witnessed in recent years important advancements towards the ultimate goal of augmenting and restoring human functions through technology and a ...

EPFL2018

Electronic solutions for power system emulation

Guillaume Olivier Lanz

Nowadays electric power systems are subject to continuous changes and the needs in the power generation and delivery service are constantly increasing, with a higher complexity of a progressively more distributed network. Because the impact of a failure ca ...

EPFL2017