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Related publications (32)

Protein Engineering for Personalized therapy and diagnosis

Lixia Wei

Protein Engineering, especially protein post-translational modification (PTM), ex-tends proteomes in a more complex way than one can expect from analysis of their encod-ing genomes. It can activate or deactivate certain catalytic functions, add new desired ...

EPFL2022

A Manganese Phosphate Nanocluster Activates the cGAS‐STING Pathway for Enhanced Cancer Immunotherapy

Li Tang, Yugang Guo, Yuqing Xie, Min Gao, Armand Kurum, Kewen Lei, Yu Zhao, Xiaomeng Hu, Simon Bart M. Van Herck

Targeting the stimulator of interferon genes (STING) pathway with cyclic dinucleotides (CDNs), the natural STING agonists, is a promising immunotherapeutic strategy for cancer. However, the clinical application of natural CDNs as therapeutics is greatly hi ...

2021

Lanthanide-Based Peptide-Directed Visible/Near-Infrared Imaging and Inhibition of LMP1

Jean-Claude Bünzli, Yue Wu

A lanthanide-based peptide-directed bioprobe LnP19 (Ln = Eu or Yb) is designed as an impressive example of a small molecule-based dual-functional probe for the EBV oncoprotein LMP1. The peptide P19 (Pra-KAhx-K-LDLALK-FWLY-K-IVMSDKW-K-RrRK) is designed to s ...

AMER CHEMICAL SOC2021

The E protein-TCF1 axis controls gamma delta T cell development and effector fate

Freddy Radtke

TCF1 plays a critical role in T lineage commitment and the development of alpha beta lineage T cells, but its role in gamma delta T cell development remains poorly understood. Here, we reveal a regulatory axis where T cell receptor (TCR) signaling controls ...

2021

Human genomics of the humoral immune response against polyomaviruses

Jacques Fellay, Christian Axel Wandall Thorball, Olivier Noël Marie Naret, Christian Hammer, Flavia Aurelia Shoko Hodel, Zhi Ming Xu, Petar Scepanovic

Human polyomaviruses are widespread in humans and can cause severe disease in immunocompromised individuals. To identify human genetic determinants of the humoral immune response against polyomaviruses, we performed genome-wide association studies and meta ...

OXFORD UNIV PRESS2021

Cell-autonomous inflammation of BRCA1-deficient ovarian cancers drives both tumor-intrinsic immunoreactivity and immune resistance via STING

Julien Dorier, George Coukos, Christian Iseli, Mauro Delorenzi, Alizée Jéléna Grimm, Giovanni Ciriello, Alexandre Harari, Marco Mina

In this study, we investigate mechanisms leading to inflammation and immunoreactivity in ovarian tumors with homologous recombination deficiency (HRD). BRCA1 loss is found to lead to transcriptional reprogramming in tumor cells and cell-intrinsic inflammat ...

2021

m6A methylation potentiates cytosolic dsDNA recognition in a sequence-specific manner

Andrea Ablasser, Muhammet Fatih Gülen

Nucleic acid sensing through pattern recognition receptors is critical for immune recognition of microbial infections. Microbial DNA is frequently methylated at the N-6 position of adenines (m6A), a modification that is rare in mammalian host DNA. We show ...

ROYAL SOC2021

Inborn errors of type I IFN immunity in patients with life-threatening COVID-19

Jacques Fellay, Rui Yang, Jie Chen, Yu Zhang, Xavier Duval, Peng Zhang, Qian Zhang, Zhiyong Liu, Juan Li

Clinical outcome upon infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ranges from silent infection to lethal coronavirus disease 2019 (COVID-19). We have found an enrichment in rare variants predicted to be loss-of-function (LOF ...

American Association for the Advancement of Science2020

Adjuvant-free immunization with infective filarial larvae as lymphatic homing antigen carriers

Melody Swartz, Marcela Rincón-Restrepo, Sachiko Hirosue, Witold Waldemar Kilarski, Alexandre de Titta, Esra Güç, David Scott Wilson

Controlled infection with intestinal nematodes has therapeutic potential for preventing the symptoms of allergic and autoimmune diseases. Here, we engineered larvae of the filarial nematode Litomosoides sigmodontis as a vaccine strategy to induce adaptive ...

Nature Research2020

In Vivo Pre-Instructed HSCs Robustly Execute Asymmetric Cell Divisions In Vitro

Matthias Lütolf, Aline Roch, Mukul Girotra, Vincent Trachsel

Hematopoietic stem cells (HSCs) are responsible for life-long production of all mature blood cells. Under homeostasis, HSCs in their native bone marrow niches are believed to undergo asymmetric cell divisions (ACDs), with one daughter cell maintaining HSC ...

2020

cGAS regulation and activity during genotoxic stress

Sélène-Véronique Glück

The innate immune system has evolved to detect pathogens through germlineencoded pattern recognition receptors (PRRs). Nucleic acid sensors, a defined class of PRRs, bind to microbial and viral nucleic acids and trigger the production of type I interferons ...

EPFL2020

Selection of Vibrio crassostreae relies on a plasmid expressing a type 6 secretion system cytotoxic for host immune cells

Melanie Blokesch, Candice Stoudmann, Frédérique Marie Jeanne Le Roux

Pacific oyster mortality syndrome affects juveniles of Crassostrea gigas oysters and threatens the sustainability of commercial and natural stocks of this species. Vibrio crassostreae has been repeatedly isolated from diseased animals and the majority of t ...

2020

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