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Alexandre de Titta

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Related publications (13)

Please note that this is not a complete list of this person’s publications. It includes only semantically relevant works. For a full list, please refer to Infoscience.

Adjuvant-free immunization with infective filarial larvae as lymphatic homing antigen carriers

Melody Swartz, Alexandre de Titta, Witold Waldemar Kilarski, Sachiko Hirosue, Marcela Rincón-Restrepo, Esra Güç, David Scott Wilson

Controlled infection with intestinal nematodes has therapeutic potential for preventing the symptoms of allergic and autoimmune diseases. Here, we engineered larvae of the filarial nematode Litomosoides sigmodontis as a vaccine strategy to induce adaptive ...

Nature Research2020

Toll-like receptor 8 agonist nanoparticles mimic immunomodulating effects of the live BCG vaccine and enhance neonatal innate and adaptive immune responses

Jeffrey Alan Hubbell, Melody Swartz, Alexandre de Titta, Sachiko Hirosue, Daniel Kenneth Bonner

Background: Newborns display distinct immune responses, leaving them vulnerable to infections and impairing immunization. Targeting newborn dendritic cells (DCs), which integrate vaccine signals into adaptive immune responses, might enable development of a ...

2017

Fibronectin EDA and CpG synergize to enhance antigen-specific Th1 and cytotoxic responses

Jeffrey Alan Hubbell, Melody Swartz, Alexandre de Titta, Ziad Julier, Eleonora Simeoni, Alizée Jéléna Grimm

Subunit vaccines, employing purified protein antigens rather than intact pathogens, require the addition of adjuvants for enhanced immunogenicity with a correct balance between strong activation of the immune system and low toxicity. Here we show that the ...

Elsevier Sci Ltd2016