Concept

Nicolaou Taxol total synthesis

Related publications (15)

Carboxylic acid isomer-directed synthesis of CdS nanocluster isomers

Selective synthesis of nanocluster (NC) isomers with tailored structures holds significant importance for enhancing their applications. Here, we develop an effective strategy for the selective synthesis of CdS NC isomers through the judicious choice of a p ...

Royal Soc Chemistry2024

Synthesis and Applications of Ynimines and Enantioselective Total Synthesis of Artatrovirenol A

Rémi Hugo Lavernhe

The first chapter of this thesis describe the development of a general synthesis of ynimines, an under-exploited motif in organic chemistry. In the presence of an inexpensive copper catalyst and 2,2'-biquinoline, reaction of easily accessible O-acyloximes ...

EPFL2023

Synthesis of bicyclo[3.1.0]hexanes by (3+2) annulation of cyclopropenes with aminocyclopropanes

Jérôme Waser, Bastian Antoine Rodolphe Claude Muriel, Alec Gagnebin

We report the convergent synthesis of bicyclo[3.1.0]hexanes possessing an all-carbon quaternary center via a (3 + 2) annulation of cyclopropenes with cyclopropylanilines. Using an organic or an iridium photoredox catalyst and blue LED irradiation, good yie ...

2019

Total Synthesis of Alstolactine A & Synthetic Studies Towards Members of Akuammiline Alkaloids

Raphaël Beltran

The work presented in this thesis focuses on the synthesis of monoterpene indole alkaloids. The first part describes the development of a general methodology to provide an enantioenriched platform, useful for the convergent synthesis of Akuammiline alkalo ...

EPFL2019

Selective synthesis of dimethyl ether on eco-friendly K10 montmorillonite clay

Jeremy Luterbacher, Oliver Kröcher, Florent Emmanuel Héroguel, Alimohammad Bahmanpour, Christophe Jean Baranowski

The methanol dehydration reaction was studied over environmentally benign, easily accessible and inexpensive K10 montmorillonite clay used as the catalyst at a temperature range between 200–700 °C. Nearly 100% selectivity towards dimethyl ether (DME) at 80 ...

2018

Indole Alkaloids, Macrocycles and Heterocycles : Interplay between Methodological Development and Total Synthesis

Cyril Piemontesi

An enantioselective total synthesis of (-)-terengganensine A, a heptacyclic monoterpene indole alkaloid, was performed. A short sequence allowed to obtain the enantio-enriched target in good overall yield. The synthesis featured a key asymmetric transfer h ...

EPFL2018

Stereoselective synthesis of alkenes via base-metal-catalyzed addition reactions to alkynes and activation of hydrogen peroxide and carbon dioxide by iron complexes

Fedor Zhurkin

Alkene functionality can be found in the majority of natural products, drugs, catalysts and organic materials. Therefore, methods of C-C double bond formation constitute a cornerstone of organic synthesis. Selective formation of either (Z)- or (E)-isomer i ...

EPFL2017

Direct amidation of esters with nitroarenes

Xile Hu, Chi Wai Cheung, Marten Leendert Ploeger

Esters are one of the most common functional groups in natural and synthetic products, and the one-step conversion of the ester group into other functional groups is an attractive strategy in organic synthesis. Direct amidation of esters is particularly ap ...

Nature Publishing Group2017

Divergent Reactivity of Thioalkynes in Lewis Acid Catalyzed Annulations with Donor-Acceptor Cyclopropanes

Rosario Scopelliti, Jérôme Waser, Sophie Lucie Racine, Bence Márton Hegedüs

Efficient methods for the convergent synthesis of (poly) cyclic scaffolds are urgently needed in synthetic and medicinal chemistry. Herein, we describe new annulation reactions of thioalkynes with phthalimide-substituted donor-acceptor cyclopropanes, which ...

Wiley-Blackwell2016

Synthesis, Properties, and Two-Dimensional Adsorption Characteristics of 5-Amino[6]hexahelicene

Magalí Alejandra Lingenfelder

A convergent synthesis of racemic 5-amino[6]hexahelicene is described. Cross-coupling reactions are used to assemble a pentacyclic framework, and a metal-catalyzed ring-closure comprises the final step. The enantiomers were separated by means of chromatogr ...

Wiley-Blackwell2016

Total Synthesis of Aspidosperma Family Indole Alkaloids through the iORC Domino Process

Olivier Wagnières

This thesis describes a unified strategy for the synthesis of monoterpene indole alkaloids of the Aspidosperma family. These syntheses feature two key steps: (1) a palladiumcatalyzed decarboxylative vinylation that provides quick access to cyclopentene int ...

EPFL2015

Direct and selective synthesis of a wide range of carbon nanomaterials by CVD at CMOS compatible temperatures

Giovanni De Micheli, László Forró, Sandro Carrara, Arnaud Magrez, Irene Taurino

Biosensors benefit from specific nano- to monitor human metabolites [1], [2]. Moreover, small structuration of the active bio-interface layer. In this electrodes allow us to design many sensing sites, each perspective, a wide range of carbon nanomaterials ...

2014

Convergent Synthesis of Near-Infrared Absorbing, "Push-Pull", Bisthiophene-Substituted, Zinc(II) Phthalocyanines and their Application in Dye-Sensitized Solar Cells

Michael Graetzel, Mohammad Khaja Nazeeruddin, Jun Ho Yum

Zinc(II) phthalocyanine dyes that contain triarylamine-terminated bisthiophene and hexylbisthiophene groups have been synthesized by a convergent approach by using carboxytriiodoZnPc as a precursor. Further transformation of the iodo groups by a Pd-catalyz ...

2012

Stereoselective syntheses of polyhydroxylated azepane derivatives from sugar-based epoxyamides. Part 1: synthesis from D-mannose

Pierre Vogel, Claudia Bello

An approach to the synthesis of polyhydroxyazepane derivatives from sugar-based epoxyamides or epoxyalcohols, in which the total regioselective epoxide opening by nitrogen nucleophiles is the key step, is described. Thus, novel polyhydroxyazepane carboxami ...

2010

Dissymmetrical Double-Chain Elongation Approach to the Asymmetric Synthesis of Long-Chain Polypropionates

Claudia Jana Exner

Polyketides show interesting biological activities and therefore represent an important class of natural products. The necessity of their diastereo- and enantioselective synthesis led to the development of numerous methodologies. A brief overview of this t ...

EPFL2010