Publications related to Dual inheritance theory

Variant-specific pathophysiological mechanisms of AFF3 differently influence transcriptome profiles

Giovanna Ambrosini, Nicolas Jean Philippe Guex, Christian Iseli

Background: We previously described the KINSSHIP syndrome, an autosomal dominant disorder associated with intellectual disability (ID), mesomelic dysplasia and horseshoe kidney,caused by de novo variants in the degron of AFF3. Mouse knock-ins and overexpre ...

BMC2024

WikiArtVectors: Style and Color Representations of Artworks for Cultural Analysis via Information Theoretic Measures

Bhargav Srinivasa Desikan

With the increase in massive digitized datasets of cultural artefacts, social and cultural scientists have an unprecedented opportunity for the discovery and expansion of cultural theory. The WikiArt dataset is one such example, with over 250,000 high qual ...

MDPI2022

Stabilization of cultural innovations depends on population density: Testing an epidemiological model of cultural evolution against a global dataset of rock art sites and climate-based estimates of ancient population densities

John Richard Walker, Taylor Howard Newton, Francesco Casalegno

Demographic models of human cultural evolution have high explanatory potential but weak empirical support. Here we use a global dataset of rock art sites and climate and genetics-based estimates of ancient population densities to test a new model based on ...

2021

Quasi-static shear-compression tests on stone masonry walls with plaster: Influence of load history and axial load ratio

Katrin Beyer, Francesco Vanin, Shenghan Zhang, Michele Godio

This paper describes quasi-static cyclic shear-compression tests on six plastered single-leaf stone masonry walls. Of the six walls, four are tested under different axial load ratios, performing a cyclic load history with two cycles per increasing drift de ...

2019

Estimates for the stiffness, strength and drift capacity of stone masonry walls based on 123 quasi-static cyclic tests reported in the literature

Katrin Beyer, Francesco Vanin, Dario Zaganelli, Andrea Penna

This paper summarises 123 existing quasi-static shear–compression tests on stone masonry walls and evaluates the results to provide the input required for the displacement-based assessment of stone masonry buildings. Based on the collected data, existing c ...

2017

Genetic Determinism vs. Phenotypic Plasticity in Protist Morphology

Edward Mitchell, Bjorn Jozef Maria Robroek, Mariusz Lamentowicz, Enrique Lara

Untangling the relationships between morphology and phylogeny is key to building a reliable taxonomy, but is especially challenging for protists, where the existence of cryptic or pseudocryptic species makes finding relevant discriminant traits difficult. ...

Wiley2017

Modeling Flow Pattern and Evolution of Meandering Channels with a Nonlinear Model

Koen Blanckaert

Meander dynamics has been the focus of river engineering for decades; however, it remains a challenge for researchers to precisely replicate natural evolution processes of meandering channels with numerical models due to the high nonlinearity of the govern ...

Mdpi Ag2016

Quantitative single-cell analysis of S. cerevisiae using a microfluidic live-cell imaging platform

Johannes Becker

Genome-wide manipulations and measurements have made huge progress over the last decades. In Saccharomyces cerevisiae, a well-studied eukaryotic model organism, homologous recombination allows for systematic deletion or alteration of a majority of its gene ...

EPFL2015

A Systems Approach to Identify Genetic and Environmental Regulators of Metabolism

Evan Graehl Williams

For more than a century, it has been recognized that our genetic inheritance and our environment interact to shape who we are and how we act (nature vs. nurture ), and the study of genetics has allowed us to explain why traits can vary dramatically betwee ...

EPFL2014

Viability Principles for Constrained Optimization Using a (1+1)-CMA-ES

Dario Floreano, Andrea Maesani

Viability Evolution is an abstraction of artificial evolution which operates by eliminating candidate solutions that do not satisfy viability criteria. Viability criteria are defined as boundaries on the values of objectives and constraints of the problem ...

Springer International Publishing2014

Characterizing the Influence of Effective Population Size on the Rate of Adaptation: Gillespie's Darwin Domain

Jeffrey David Jensen

Characterizing the role of effective population size in dictating the rate of adaptive evolution remains a major challenge in evolutionary biology. Depending on the underlying distribution of fitness effects of new mutations, populations of different sizes ...

2011

Comprehensive analysis of Arabidopsis expression polymorphisms with simple inheritance

Darlene Goldstein

In Arabidopsis thaliana, gene expression level polymorphisms (ELPs) between natural accessions that exhibit simple, single locus inheritance are promising quantitative trait locus (QTL) candidates to explain phenotypic variability. It is assumed that such ...

2009

Computational models in the debate over language learnability

Frédéric Kaplan

Computational models have played a central role in the debate over language learnability. This article discusses how they have been used in different stances, from generative views to more recently introduced explanatory frameworks based on embodiment, cog ...

2008