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Related publications (29)

A new class of protein biomarkers based on subcellular distribution: application to a mouse liver cancer model

Kristina Schoonjans, Vera Monica Lemos Da Silva, Evan Graehl Williams, Pan Xu, Amir Banaei Esfahani, Chen Li, Ruedi Aebersold

To-date, most proteomic studies aimed at discovering tissue-based cancer biomarkers have compared the quantity of selected proteins between case and control groups. However, proteins generally function in association with other proteins to form modules loc ...

Nature Research2019

Microfluidic-based immunohistochemistry for breast cancer diagnosis: a comparative clinical study

Martinus Gijs, Diego Gabriel Dupouy, Saska Brajkovic, Fabio Aimi

Breast cancer is a highly heterogeneous disease. The efficacy of tailored therapeutic strategies relies on the precise detection of diagnostic biomarkers by immunohistochemistry (IHC). Therefore, considering the increasing incidence of breast cancer cases, ...

2019

Stroke and Amyloid-beta Downregulate TREM-2 and Uch-L1 Expression that Synergistically Promote the Inflammatory Response

Ivan Enrico Repetto

Neuroinflammation is involved in the pathogenesis of Alzheimer's disease, and the transcription factor NF-kappa B is a player in this event. We found here that the ischemic damage alone or in association with A beta(1-42) activates the NF-kappa B pathway, ...

2019

Differentiating Parkinson's disease motor subtypes using automated volume-based morphometry incorporating white matter and deep gray nuclear lesion load

Bénédicte Marie Maréchal

Background Periventricular leukoaraiosis may be an important pathological change in postural instability gait disorder (PIGD), a motor subtype of Parkinson's disease (PD). Clinical diagnosis of PIGD may be challenging for the general neurologist. Purpose T ...

2020

Aerolysin, a Powerful Protein Sensor for Fundamental Studies and Development of Upcoming Applications

Françoise Gisou van der Goot Grunberg

The nanopore electrical approach is a breakthrough in single molecular level detection of particles as small as ions, and complex as biomolecules. This technique can be used for molecule analysis and characterization as well as for the understanding of con ...

AMER CHEMICAL SOC2019

Nanoparticle-Enhanced Plasmonic Biosensor for Digital Biomarker Detection in a Microarray

Hatice Altug, Alexander Belushkin, Filiz Yesilköy

Nanoplasmonic devices have become a paradigm for biomolecular detection enabled by enhanced light–matter interactions in the fields from biological and pharmaceutical research to medical diagnostics and global health. In this work, we present a bright-fiel ...

2018

Organoid Profiling Identifies Common Responders to Chemotherapy in Pancreatic Cancer

Candice Megan T Young

Pancreatic cancer is the most lethal common solid malignancy. Systemic therapies are often ineffective, and predictive biomarkers to guide treatment are urgently needed. We generated a pancreatic cancer patient-derived organoid (PDO) library that recapitul ...

2018

Enhanced Sensing of Interleukin 8 by Stripping Voltammetry: Carbon Nanotubes versus Fullerene

Sandro Carrara, Tugba Kilic, Sarah Tonello

The ability to detect protein biomarkers at a subnanomolar level represents a pervasive challenge in order to bring a significant improvement in early diagnosis or progression of pato-physiological processes. To this aim, Screen Printed Electrochemical Sen ...

SPRINGER-VERLAG SINGAPORE PTE LTD2018

On-Chip Spyhole Nanoelectrospray Ionization Mass Spectrometry for Sensitive Biomarker Detection in Small Volumes

Hubert Girault, Xiaoqin Zhong, Liang Qiao, Géraldine Margaretha Alice Stauffer

A polyimide microfluidic chip with a microhole emitter (Ø 10–12 μm) created on top of a microchannel by scanning laser ablation has been designed for nanoelectrospray ionization (spyhole-nanoESI) to couple microfluidics with mass spectrometry. The spyhole- ...

2018

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