Publications related to Chronic inflammatory demyelinating polyneuropathy

Comprehensive proteomic analysis of JC polyomavirus-infected human astrocytes and their extracellular vesicles

JC polyomavirus (JCPyV) is an opportunistic virus that remains in a latent state in the kidneys and lymphoid organs of more than half of the human adult population. In rare cases of severe immune suppression, the virus is able to establish a lytic infectio ...

Amer Soc Microbiology2023

A Polyester–Nylon Blend Plantar Pressure Sensing Insole for Person With Diabetes

Yves Perriard, Yoan René Cyrille Civet, Paolo Germano, Christian Köchli, Sofia Lydia Ntella, Kenny Jeanmonod, Bhawnath Tiwari

Peripheral sensorimotor neuropathy among people with diabetes is one of the leading causes of foot ulceration. Plantar pressure is a significant parameter to control for the prevention of foot ulceration. A low-cost sensing insole, which can provide a reli ...

2023

The effect of mindfulness-based intervention on neurobehavioural functioning and its association with white-matter microstructural changes in preterm young adolescents

Dimitri Nestor Alice Van De Ville, Lorena Gonçalves de Alcântara e Freitas Krikler, Vanessa Siffredi, Petra Susan Hüppi

Very preterm (VPT) young adolescents are at high risk of executive, behavioural and socio-emotional difficulties. Previous research has shown significant evidence of the benefits of mindfulness-based intervention (MBI) on these abilities. This study aims t ...

Nature Portfolio2023

Fractal analysis in the quantification of medical imaging associated with multiple sclerosis pathology

Maria-Alexandra Paun

Backgrounds: Multiple sclerosis (MS) is an inveterate phlogistic situation characterized by focal and vaguely diffusive de-myelination and neurodegeneration, in the sphere of central nervous system (CNS). The brain's chronic inflammatory reaction includes ...

IMR PRESS2022

Deep learning-based analysis of multiple sclerosis lesions with high and ultra-high field MRI

Francesco La Rosa

Multiple sclerosis (MS) is the most common demyelinating disease of the central nervous system and affects almost 3 million people worldwide. There is currently no cure for MS, and its symptoms, starting with fatigue and weakness, often progress over time ...

EPFL2022

Probing myelin content of the human brain with MRI: A review

Jean-Philippe Thiran, Tobias Kober, Tom Hilbert, Gian Franco Piredda

Rapid and efficient transmission of electric signals among neurons of vertebrates is ensured by myelin-insulating sheaths surrounding axons. Human cognition, sensation, and motor functions rely on the integrity of these layers, and demyelinating diseases o ...

WILEY2021

Challenges for biophysical modeling of microstructure

Ileana Ozana Jelescu

The biophysical modeling efforts in diffusion MRI have grown considerably over the past 25 years. In this review, we dwell on the various challenges along the journey of bringing a biophysical model from initial design to clinical implementation, identifyi ...

2020

Unified multi-modal characterization of microstructural parameters of brain tissue using diffusion MRI and multi-echo T2 data

Jean-Philippe Thiran, Erick Jorge Canales Rodriguez, Alessandro Daducci, Nicolas Kunz, Marco Pizzolato

In this study, a unified framework to estimate different microstructure indices from diffusion MRI and multi-echo T2 (MET2) data was proposed.The new methodology takes into account the common and complementary information provided by both modalities. While ...

2018

Association of brain amyloidosis with pro-inflammatory gut bacterial taxa and peripheral inflammation markers in cognitively impaired elderly

Tristan Bolmont, Taoufiq Harach

The pathway leading from amyloid-b deposition to cognitive impairment is believed to be a cornerstone of the pathogenesis of Alzheimer's disease (AD). However, what drives amyloid buildup in sporadic nongenetic cases of AD is still unknown. AD brains featu ...

Elsevier Science Inc2017

Fingolimod protects against neonatal white matter damage and long-term cognitive deficits caused by hyperoxia

Yohan Van de Looij

Cerebral white matter injury is a leading cause of adverse neurodevelopmental outcome in prematurely born infants involving cognitive deficits in later life. Despite increasing knowledge about the pathophysiology of perinatal brain injury, therapeutic opti ...

Elsevier2016

Mesenchymal stem cell-derived extracellular vesicles ameliorate inflammation-induced preterm brain injury

Yohan Van de Looij

Objective Preterm brain injury is a major cause of disability in later life, and may result in motor, cognitive and behavioural impairment for which no treatment is currently available. The aetiology is considered as multifactorial, and one underlying key ...

Elsevier2016

Clinical Proton MR Spectroscopy in Central Nervous System Disorders

Rolf Gruetter, Cristina Ramona Cudalbu

A large body of published work shows that proton (hydrogen 1 [(1)H]) magnetic resonance (MR) spectroscopy has evolved from a research tool into a clinical neuroimaging modality. Herein, the authors present a summary of brain disorders in which MR spectrosc ...

2014

Synaptic and cellular organization of layer 1 of the developing rat somatosensory cortex

Henry Markram, Shruti Muralidhar, Yun Wang

Layer 1 of the neocortex is sparsely populated with neurons and heavily innervated by fibers from lower layers and proximal and distal brain regions. Understanding the potential functions of this layer requires a comprehensive understanding of its cellular ...

Frontiers Research Foundation2014

Ammonia toxicity to the brain

Cristina Ramona Cudalbu

Hyperammonemia can be caused by various acquired or inherited disorders such as urea cycle defects. The brain is much more susceptible to the deleterious effects of ammonium in childhood than in adulthood. Hyperammonemia provokes irreversible damage to the ...

Springer Verlag2013

Developmental expression of Synaptotagmin isoforms in single calyx of Held-generating neurons

Ralf Schneggenburger, Olexiy Kochubey, Yunyun Han, Heather Mary Elizabeth Murray, Heike Runne, Le Xiao

The large glutamatergic calyx of Held synapse in the auditory brainstem has become a powerful model for studying transmitter release mechanisms, but the molecular bases of presynaptic function at this synapse are not well known. Here, we have used single-c ...

2010

Insulin-like growth factor-1 and neurotrophin-3 gene therapy prevents motor decline in an X-linked adrenoleukodystrophy mouse model

Patrick Aebischer, Jean-Charles Bensadoun

X-linked adrenoleukodystrophy (X-ALD) is the most common inherited peroxisomal disorder characterized by a progressive demyelination of the central nervous system. The marked loss of myelin and oligodendrocytes observed in the disease prompted us to evalua ...

2009

Notch controls embryonic Schwann cell differentiation, postnatal myelination and adult plasticity

Freddy Radtke

Notch signaling is central to vertebrate development, and analysis of Notch has provided important insights into pathogenetic mechanisms in the CNS and many other tissues. However, surprisingly little is known about the role of Notch in the development and ...

2009

A Neural Model of Demyelination of the Mouse Spinal Cord

Biljana Petreska von Ritter-Zahony

This paper presents a neural network model of demyelination of the mouse motor pathways, coupled to a central pattern generation (CPG) model for quadruped walking. Demyelination is the degradation of the myelin layer covering the axons which can be caused ...

2008

Direct Muscle Delivery of GDNF With Human Mesenchymal Stem Cells Improves Motor Neuron Survival and Function in a Rat Model of Familial ALS

Patrick Aebischer

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease in which there is a progressive loss of motor neurons and their connections to muscle, leading to paralysis. In order to maintain muscle connections in a rat model of familial ALS (FA ...

2008

Chronic activation in presymptomatic amyotrophic lateral sclerosis (ALS) mice of a feedback loop involving Fas, Daxx, and FasL

Patrick Aebischer

The reasons for the cellular specificity and slow progression of motoneuron diseases such as ALS are still poorly understood. We previously described a motoneuron-specific cell death pathway downstream of the Fas death receptor, in which synthesis of nitri ...

National Academy of Sciences2006