Publications related to Sub-replacement fertility

A striatal circuit balances learned fear in the presence and absence of sensory cues

Ralf Schneggenburger, Olexiy Kochubey, Michael Kintscher

During fear learning, defensive behaviors like freezing need to be finely balanced in the presence or absence of threat-predicting cues (conditioned stimulus, CS). Nevertheless, the circuits underlying such balancing are largely unknown. Here, we investiga ...

eLIFE SCIENCES PUBL LTD2023

The matricellular protein Drosophila Cellular Communication Network Factor is required for synaptic transmission and female fertility

Evelyne Ruchti, Brian Donal McCabe

Within the extracellular matrix, matricellular proteins are dynamically expressed nonstructural proteins that interact with cell surface receptors, growth factors, and proteases, as well as with structural matrix proteins. The cellular communication networ ...

Genetics Society America2022

An insular cortex - lateral amygdala network in fear learning

Shriya Palchaudhuri

Animals are capable of evaluating sensory cues for possible threats and adapting their behaviours accordingly. Fear learning is an evolutionarily conserved behaviour crucial for animal survival, during which sensory percepts with a negative reinforcing qua ...

EPFL2022

International Migration And The Growth Of Zurich, 1836-1949

Mathias Lerch

The role played by international migration and its interactions with other demographic components in the process of city growth remains underappreciated. We analyze trends in natural increase and in net internal and international migration in Zurich during ...

2021

Both diversity and functional composition affect productivity and water use efficiency in experimental temperate grasslands

Charlotte Grossiord, Margaux Clara Lou Didion-Gency

Many experiments have shown that biodiversity promotes ecosystem functioning and stability and that this relationship varies with resource availability. However, we still have a poor understanding of the underlying physiological and ecological mechanisms d ...

WILEY2021

Tensile response of Strain-Hardening Ultra High Performance Fiber Reinforced Concretes under low loading rates and low temperatures

Mohamed Abdul Hafiz

Strain Hardening Ultra High Performance Fiber Reinforced Concretes (SH-UHPFRC) are cementitious materials with exceptional mechanical properties and outstanding durability making them ideal materials for rehabilitation, for the improvement of load carrying ...

EPFL2019

Analysis of runaway electron expulsion during tokamak instabilities detected by a single-channel Cherenkov probe in FTU

Cristian Galperti, Gabriele Grosso, Filippo Bagnato

The expulsion of runaway electrons (REs) during different types of tokamak instabilities is analysed by means of a Cherenkov probe inserted into the scrape-off layer of the FTU tokamak. One such type of instability, the well-known tearing mode, is involved ...

IOP Publishing Ltd2019

Evolution of longevity improves immunity in Drosophila

Bruno Lemaitre

Much has been learned about the genetics of aging from studies in model organisms, but still little is known about naturally occurring alleles that contribute to variation in longevity. For example, analysis of mutants and transgenes has identified insulin ...

JOHN WILEY & SONS LTD2018

Critical dynamics in population vaccinating behavior

Marcel Salathé, Sharada Prasanna Mohanty

Vaccine refusal can lead to renewed outbreaks of previously eliminated diseases and even delay global eradication. Vaccinating decisions exemplify a complex, coupled system where vaccinating behavior and disease dynamics influence one another. Such systems ...

National Academy of Sciences2017

iNVESTIGA: Connecting the Colombian Scientific Diaspora with Secondary Schools in Colombia

Rafael Eduardo Carrillo Rangel, Ricardo Alberto Corredor Jerez

According to recent studies, Latin America is the region with the highest emigration rate in the world, specially affecting the highly educated population. One of the consequences of this process is the expansion of business and scientific diasporas. Colom ...

2016

Does Proton Conduction in the Voltage-Gated H+ Channel hHv1 Involve Grotthuss-Like Hopping via Acidic Residues?

Ursula Röthlisberger, Siri Camee van Keulen, Lucie Monique Françoise Delemotte

Hv1s are ubiquitous highly selective voltage-gated proton channels involved in male fertility, immunology, and the invasiveness of certain forms of breast cancer. The mechanism of proton extrusion in Hv1 is not yet understood, while it constitutes the firs ...

2016

Mutations in the polyglutamylase geneTTLL5, expressed in photoreceptor cells and spermatozoa, are associated with cone-rod degeneration and reduced male fertility

Hereditary retinal degenerations encompass a group of genetic diseases characterized by extreme clinical variability. Following next-generation sequencing and autozygome-based screening of patients presenting with a peculiar, recessive form of cone-dominat ...

Oxford University Press2016

Anomaly detection in elderly daily behavior in ambient sensing environments

Daniel Gatica-Perez, Oya Aran, Dairazalia Sanchez Cortes

Current ubiquitous computing applications for smart homes aim to enhance people’s daily living respecting age span. Among the target groups of people, elderly are a population eager for “choices for living arrangements”, which would allow them to continue ...

Springer Int Publishing Ag2016

Bile Acids Alter Male Fertility Through G-Protein-Coupled Bile Acid Receptor 1 Signaling Pathways in Mice

Kristina Schoonjans

Bile acids (BAs) are signaling molecules that are involved in many physiological functions, such as glucose and energy metabolism. These effects are mediated through activation of the nuclear and membrane receptors, farnesoid X receptor (FXR-alpha) and TGR ...

Wiley-Blackwell2014

A bottom-up stochastic model to predict building occupants' time-dependent activities

Jean-Louis Scartezzini, Darren Robinson, Frédéric Haldi, Urs Wilke

A bottom-up modelling approach together with a set of calibration methodologies is presented to predict residential building occupants' time-dependent activities, for use in dynamic building simulations. The stochastic model to predict activity chains is c ...

Elsevier2013

The Glucocorticoid-Induced Leucine Zipper (Gilz/Tsc22d3-2) Gene Locus Plays a Crucial Role in Male Fertility

Friedrich Beermann, Roman Chrast, Jian Wang, Anne Wilson

The glucocorticoid-induced leucine zipper (Tsc22d3-2) is a widely expressed dexamethasone-induced transcript that has been proposed to be important in immunity, adipogenesis, and renal sodium handling based on in vitro studies. To address its function in v ...

2012

Global human tissue profiling and protein network analysis reveals distinct levels of transcriptional germline-specificity and identifies target genes for male infertility

Alexandre Gattiker

Mammalian spermatogenesis is a process that involves a complex expression program in both somatic and germ cells present in the male gonad. A number of studies have attempted to define the transcriptome of male meiosis and gametogenesis in rodents and prim ...

Oxford University Press2012

Mécanismes rétroactifs de ségrégation, entre une société urbaine et son espace : Un modèle basé agents

André Ourednik

This paper describes an agent-based model of socio-spatial segregation, result of a synthesis between « Schelling’s spatial segregation model » and a demographc model of dependency between household fertility rates and socio-economical status of their desc ...

2007

The Swiss experience on the wear of railway switches & crossings

Willem-Jan Zwanenburg

Using databases of the Swiss Federal Railways (SBB CFF FFS), statistical analyses are carried out on the expected lifetime of railway switches (points) & crossings and their respective components. The expected lifetimes are attributed to different paramete ...

2007

Multiple glycerol shocks increase the calcium phosphate transfection of non-synchronized CHO cells

Florian Maria Wurm, David Hacker, Martin Bertschinger, Frédéric Grosjean

The exposure of CHO DG44 cells to an osmotic shock, after DNA uptake, results in a cellular volume decrease of approx. 55%. Repetitive osmotic shocks targeted different sub-populations of cells as was demonstrated using two different fluorescent reporter g ...

2006