Publications related to Evolutionary physiology

Invasive palms have more efficient and prolonged CO2 assimilation compared to native sub-Mediterranean vegetation

Charlotte Grossiord, Christoph Bachofen, Thibaut Michel Georges Juillard, Janisse Deluigi, Marco Conedera

In sub-Mediterranean ecosystems, shade-tolerant broadleaf evergreens, especially the invasive Trachycarpus fortunei, are spreading uncontrollably in the forest understorey, impeding the regeneration of the native deciduous woody vegetation. Most invasive s ...

Elsevier2024

Development of a Robotic Microsurgeon for Embryonic Research

Ece Özelçi

Understanding how biological matter takes its shape is instrumental to biology, bioengineering, medicine, and bioinspired engineering. Gaining information on the principles of morphogenesis could enable clinicians to correct developmental abnormalities, ev ...

EPFL2023

Back-to-Africa introductions of Mycobacterium tuberculosis as the main cause of tuberculosis in Dar es Salaam, Tanzania

Jacques Fellay, Zhi Ming Xu

In settings with high tuberculosis (TB) endemicity, distinct genotypes of the Mycobacterium tuberculosis complex (MTBC) often differ in prevalence. However, the factors leading to these differences remain poorly understood. Here we studied the MTBC populat ...

PUBLIC LIBRARY SCIENCE2023

Genomics of Preaxostyla Flagellates Illuminates the Path Towards the Loss of Mitochondria

Marek Elias, Shweta Vinodrai Pipaliya

The notion that mitochondria cannot be lost was shattered with the report of an oxymonad Monocercomonoides exilis, the first eukaryote arguably without any mitochondrion. Yet, questions remain about whether this extends beyond the single species and how th ...

Public Library Science2023

Towards an Evolutionary Theory of Stress Responses

Maria del Carmen Sandi Perez

All organisms have a stress response system to cope with environmental threats, yet its precise form varies hugely within and across individuals, populations, and species. While the physiological mechanisms are increasingly understood, how stress responses ...

2021

Variants in USP48 encoding ubiquitin hydrolase are associated with autosomal dominant non-syndromic hereditary hearing loss

Nicolas Jean Philippe Guex

Non-Syndromic Hereditary Hearing Loss (NSHHL) is a genetically heterogeneous sensory disorder with about 120 genes already associated. Through exome sequencing (ES) and data aggregation, we identified a family with six affected individuals and one unrelate ...

Oxford University Press2021

Root carbon and nutrient homeostasis determines downy oak sapling survival and recovery from drought

Leonie Corine Schönbeck

The role of carbon (C) and nutrient uptake, allocation, storage and especially their interactions in survival and recovery of trees under increased frequencies and intensities of drought events is not well understood. A full factorial experiment with four ...

2021

Constraint-based metabolic control analysis for rational strain engineering

Vassily Hatzimanikatis, Ljubisa Miskovic, Meriç Ataman, Tuure Eelis Hameri, Sofia Tsouka

The advancements in genome editing techniques over the past years have rekindled interest in rational metabolic engineering strategies. While Metabolic Control Analysis (MCA) is a well-established method for quantifying the effects of metabolic engineering ...

2021

Towards Recognizing Emotion in the Latent Space

Rayan Elalamy

Emotion recognition is usually achieved by collecting features (physiological signals, events, facial expressions, etc.) to predict an emotional ground truth. This ground truth is arguably unreliable due to its subjective nature. In this paper, we introduc ...

IEEE2021

Protein Structural Information and Evolutionary Landscape by In Vitro Evolution

Paolo De Los Rios

Protein structure is tightly intertwined with function according to the laws of evolution. Understanding how structure determines function has been the aim of structural biology for decades. Here, we have wondered instead whether it is possible to exploit ...

OXFORD UNIV PRESS2020

Diet modulates cecum bacterial diversity and physiological phenotypes across the BXD mouse genetic reference population

Johan Auwerx, Evan Graehl Williams

The BXD family has become one of the preeminent genetic reference populations to understand the genetic and environmental control of phenotypic variation. Here we evaluate the responses to different levels of fat in the diet using both chow diet (CD, 13-18 ...

2019

Uncertainty reduction in biochemical kinetic models: Enforcing desired model properties

Vassily Hatzimanikatis, Ljubisa Miskovic, Michaël Roger Germain Moret

A persistent obstacle for constructing kinetic models of metabolism is uncertainty in the kinetic properties of enzymes. Currently, available methods for building kinetic models can cope indirectly with uncertainties by integrating data from different biol ...

2019

Life-history trade-offs and limitations associated with phenotypic adaptation under future ocean warming and elevated salinity

Emma Mary Gibbin, Félix Christen

Little is known about the life-history trade-offs and limitations, and the physiological mechanisms that are associated with phenotypic adaptation to future ocean conditions. To address this knowledge gap, we investigated the within-and trans-generation li ...

ROYAL SOC2019

Generalized size scaling of metabolic rates based on single-cell measurements with freshwater phytoplankton

Anders Meibom, Andrea Rinaldo, Stéphane Laurent Escrig, Andrea Giometto, Silvia Zaoli, Emilio Marañón, Amos Maritan

Kleiber's law describes the scaling of metabolic rate with body size across several orders of magnitude in size and across taxa and is widely regarded as a fundamental law in biology. The physiological origins of Kleiber's law are still debated and general ...

National Academy of Sciences2019

Cross-species functional modules link proteostasis to human normal aging

Johan Auwerx, Hao Li, Vincenzo Sorrentino, Andrea Komljenovic

The evolutionarily conserved nature of the few well-known anti-aging interventions that affect lifespan, such as caloric restriction, suggests that aging-related research in model organisms is directly relevant to human aging. Since human lifespan is a com ...

2019

Identification of novel PCTAIRE-1/CDK16 substrates using a chemical genetic screen

Kei Sakamoto, Caterina Collodet, Maria Deak

PCTAIRE-1 (also known as cyclin-dependent protein kinase (CDK) 16), is a Ser/Thr kinase that has been implicated in many cellular processes, including cell cycle, spermatogenesis, neurite outgrowth, and vesicle trafficking. Most recently, it has been propo ...

2019

Allometric Scaling of physiologically-relevant organoids

Andrea Rinaldo

The functional and structural resemblance of organoids to mammalian organs suggests that they might follow the same allometric scaling rules. However, despite their remarkable likeness to downscaled organs, non-luminal organoids are often reported to posse ...

Nature Research2019

ROS-Health: An Open-Source Framework for Neurorobotics

José del Rocio Millán Ruiz, Luca Tonin

This paper aims at providing a preliminary description of ROS-Health, a novel framework for neurorobotics based on the middleware Robot Operating System (ROS). The increased interest in the neurorobotics field and the proliferation of several (neuro) physi ...

IEEE2018

Signal Processing Approaches for Cardio-Respiratory Biosignals with an Emphasis on Mobile Health Applications

Leila Mirmohamadsadeghi

We humans are constantly preoccupied with our health and physiological status. From precise measurements such as the 12-lead electrocardiograms recorded in hospitals, we have moved on to mobile acquisition devices, now as versatile as smart-watches and sma ...

EPFL2017

Ecological strategies and metabolic trade-offs of complex environmental biofilms

Tom Ian Battin, Hannes Markus Peter

Microorganisms aggregated into matrix-enclosed biofilms dominate microbial life in most natural, engineered, and medical systems. Despite this, the ecological adaptations and metabolic trade-offs of the formation of complex biofilms are currently poorly un ...

Nature Publishing Group2017