Publications by Harald Van Lintel

How to improve the sensitivity of coplanar electrodes and micro channel design in electrical impedance flow cytometry: a study

Philippe Renaud, Harald Van Lintel, Jonathan Bastien Cottet

This paper describes a comprehensive analysis of the geometrical parameters in uencing the sensitivity of a coplanar elec- trode layout for electrical impedance ow cytometry. The designs presented in this work have been simulated, fabricated, and tested. 3 ...

2019

Dielectrophoresis‐assisted creation of cell aggregates under flow conditions using planar electrodes

Philippe Renaud, Harald Van Lintel, Soufian Lasli, Jonathan Bastien Cottet

We present a microfluidic platform allowing dielectrophoresis-assisted formation of cell aggregates of controlled size and composition under flow conditions. When specific ex- perimental conditions are met, negative dielectrophoresis allows efficient conce ...

2019

Efficacy of pulsed electromagnetic fields and electromagnetic fields tuned to the ion cyclotron resonance frequency of Ca2+ on chondrogenic differentiation

Philippe Renaud, Harald Van Lintel, Hanie Kavand

Previous studies provide strong evidence for the therapeutic effect of electromagnetic fields (EMFs) on different tissues including cartilage. Diverse exposure parameters applied in scientific reports and the unknown interacting mechanism of EMF with biolo ...

WILEY2019

Cell-Imprint Surface Modification by Contact Photolithography-Based Approaches: Direct-Cell Photolithography and Optical Soft Lithography Using PDMS Cell Imprints

Philippe Renaud, Harald Van Lintel, Shahin Bonakdar, Hanie Kavand

New cell-imprint surface modification techniques based on direct-cell photolithography and optical soft lithography using poly(dimethylsiloxane) (PDMS) cell imprints are presented for enhanced cell-based studies. The core concept of engineering materials f ...

AMER CHEMICAL SOC2019

Impedance-based real-time position sensor for lab-on-a-chip devices

Philippe Renaud, Harald Van Lintel, Jonathan Bastien Cottet

This paper presents the theoretical and experimental development of an integrated position sensor for lab-on-a-chip devices. The interest for single cell analysis is growing. However, this requires monitoring and controlling cell displacements in real time ...

2018

Quantitative chemical biosensing by bacterial chemotaxis in microfluidic chips

Harald Van Lintel, Jan Roelof van der Meer, Clémence Roggo

Whole-cell bacterial bioreporters are proposed asalternatives to chemical analysis of, for example, pol-lutants in environmental compartments. Commonlybased on reporter gene induction, bioreporters pro-duce a detectable signal within 30 min to a few hoursa ...

2018

Passive flow control valve for protein delivery

Philippe Renaud, Harald Van Lintel

Passive ow control valves are usually intended to deliver or drain a uid at a constant rate independently of pressure variations. Micro uidic devices made of a stack of two plates are considered here: the rst plate comprises a exible silicon membrane havin ...

2017

Design of a Passive Flow Regulator Using a Genetic Algorithm

Harald Van Lintel

Passive flow regulators are usually intended to deliver or drain a fluid at a constant rate independently from pressure variations. Microfluidic devices made of a stack of two plates are considered here: the first plate comprises a flexible silicon membran ...

Elsevier2016

Bi-directional AC electrothermal micropump for on-chip biological applications

Philippe Renaud, Harald Van Lintel, Jürgen Brugger, Reza Hadjiaghaie Vafaie

The ability to control and pump high ionic strength fluids inside microchannels forms a major advantage for clinical diagnostics and drug screening processes, where high conductive biological and physiological buffers are used. Despite the known potential ...

Wiley-Blackwell2016

An automated microreactor for semi-continuous biosensor measurements

Philippe Renaud, Harald Van Lintel, Jan Roelof van der Meer, Nina Buffi

Living bacteria or yeast cells are frequently used as bioreporters for the detection of specific chemical analytes or conditions of sample toxicity. In particular, bacteria or yeast equipped with synthetic gene circuitry that allows the production of a rel ...

Royal Society of Chemistry2016

Compact portable biosensor for arsenic detection in aqueous samples with Escherichia coli bioreporter cells

Philippe Renaud, Harald Van Lintel, Nina Buffi

We present a compact portable biosensor to measure arsenic As(III) concentrations in water using Escherichia coli bioreporter cells. Escherichia coli expresses green fluorescent protein in a linearly dependent manner as a function of the arsenic concentrat ...

Amer Inst Physics2014

TRAC: A new accuracy measurement standard for insulin infusion pumps

Philippe Renaud, Harald Van Lintel

2013

Remotely powered implantable heart monitoring system for freely moving animals

Philippe Renaud, Catherine Dehollain, Harald Van Lintel, Enver Gürhan Kilinç, Franco Maloberti, Alejandro Coronado Moya

This paper presents a remotely powered implantable heart monitoring system for freely moving animals. The system measures the blood pressure in the left ventricle of the heart and transmits the data to a database unit. The implanted unit is remotely powere ...

IEEE2013

Low material budget microfabricated cooling devices for particle detectors and front-end electronics

Philippe Renaud, Harald Van Lintel, Alessandro Mapelli

Novel cooling systems with very low material budget are being fabricated and studied. They consist of silicon wafers in which microchannels are etched and closed by bonding another wafer. This cooling option is being considered for future HEP detectors of ...

2011

Miniaturized bacterial biosensor system for arsenic detection holds great promise for making integrated measurement device

Philippe Renaud, Harald Van Lintel, Nina Buffi

Combining bacterial bioreporters with microfluidics systems holds great promise for in-field detection of chemical or toxicity targets. Recently we showed how Escherichia coli cells engineered to produce a variant of green fluorescent protein after contact ...

2011

Development of a microfluidics biosensor for agarose-bead immobilized Escherichia coli bioreporter cells for arsenite detection in aqueous samples

Philippe Renaud, Harald Van Lintel, Nina Buffi

Contamination with arsenic is a recurring problem in both industrialized and developing countries. Drinking water supplies for large populations can have concentrations much higher than the permissible levels (for most European countries and the United Sta ...

2011

A Ca2+ ion selective electrode biosensor in microfluidics to monitor hepatocyte’s activities

Philippe Renaud, Harald Van Lintel, Robert Meissner

Ca2+ plays a crucial role in cell communication. For example, periodical changes in Ca2+ concentration act as cell sig- nals. Intracellular Ca2+ signals have been measured by Ca2+ sensitive fluorescent dye [1]. In this study, extracellular Ca2+ variation w ...

2010

Biochip with E. coli bacteria for detection of arsenic in drinking water

Philippe Renaud, Harald Van Lintel, Joël Theytaz, Jan Roelof van der Meer, Thomas Michael Braschler

Arsenic and other pollutants are often present in trace amounts in drinking water in a number of countries. In aqueous solutions the sensitivity of arsenic- responsive bacterial bioreporters is far better than the performance of chemical field test kits. H ...

Elsevier2009

Biochip with E-Coli bacteria for detection of arsenic in drinking water

Philippe Renaud, Harald Van Lintel, Joël Theytaz, Jan Roelof van der Meer, Thomas Michael Braschler

Arsenic and other pollutants are often present in trace amounts in drinking water in a number of countries. In aqueous solutions the sensitivity of arsenic-responsive bacterial bioreporters is far better than the performance of chemical field test kits. Ho ...

2009

A virtual valve for smooth contamination-free flow switching

Philippe Renaud, Mario Schlund, Harald Van Lintel, Nicolas Demierre, Joël Theytaz, Raphaël Tornay, Thomas Michael Braschler, Anja Kunze, Grazia Loche

We present a channel geometry that allows for clean switching between different inlets of a microchip without any contamination of the inlets or the downstream flow. We drive this virtual valve with a pneumatic pressure setup that minimizes disturbance of ...

2007