Home

Person

Pierre Magistretti

About
Privacy
Disclaimer

Graph Chatbot

Related publications (180)

Norepinephrine stimulates glycogenolysis in astrocytes to fuel neurons with lactate

Pierre Magistretti, Henry Markram, Felix Schürmann, Corrado Cali, Daniel Keller, Jay Coggan

Although efficient compared to computers, the human brain utilizes energy at 10-fold the rate of other organs by mass. How the brain is supplied with sufficient on-demand energy to support its activity in the absence of neuronal storage capacity remains un ...

2018

Functional consequences of brain glycogen deficiency on the sleep-wake cycle regulation in PTG-KO mice

Pierre Magistretti, Igor Allaman, Gabriele Grenningloh, Sophie Burlet Godinot

WILEY2018

The Epistemological Foundations of Freud's Energetics Model

Pierre Magistretti

This article aims to clarify the epistemological foundations of the Freudian energetics model, starting with a historical review of the 19th century scientific context in which Freud's research lay down its roots. Beyond the physiological and anatomical re ...

Frontiers Media2018

Gender-specific alteration of energy balance and circadian locomotor activity in the Crtc1 knockout mouse model of depression

Pierre Magistretti, Jean-Marie Petit, Benjamin Boutrel, Daniel Sciarra, Jean-René Cardinaux

Obesity and depression are major public health concerns, and there is increasing evidence that they share etiological mechanisms. CREB-regulated transcription coactivator 1 (CRTC1) participates in neurobiological pathways involved in both mood and energy b ...

Springer Nature2017

A Historical Review of Diachrony and Semantic Dimensions of Trace in Neurosciences and Lacanian Psychoanalysis

Pierre Magistretti

Experience leaves a trace in the nervous system through plasticity. However, the exact meaning of the mnesic trace is poorly defined in current literature. This article provides a historical review of the term trace in neuroscience and psychoanalysis liter ...

Frontiers Media2017

A key role of glycogen derived lactate from astrocytes in cocaine associated memories

Pierre Magistretti, Benjamin Boutrel, Benjamin Boury-Jamot, Anthony Carrard

Wiley2017

Peripheral administration of lactate produces antidepressant-like effects

Pierre Magistretti, Etienne Meylan, Benjamin Boury-Jamot, Anthony Carrard

2017

Synergistic interaction of L-Lactate and Glycine to potentiate NMDA receptor activity: a new form of meta-potentiation?

Pierre Marquet, Pierre Magistretti, Pascal Jourdain, Igor Allaman, Kaspar Rothenfusser

Wiley2017

Role of MCT1 and CAII in skeletal muscle pH homeostasis, energetics, and function: in vivo insights from MCT1 haploinsufficient mice

Sylvain Eric Lengacher, Pierre Magistretti, Luc Pellerin

The purpose of this study was to investigate the effects of a partial suppression of monocarboxylate transporter (MCT)-1 on skeletalmuscle pH, energetics, and function (MCT1(+/-) mice). Twenty-fourMCT1(+/-) and 13 wild-type (WT) mice were subjected to a re ...

Federation of American Society of Experimental Biology2017

Exon-Sequencing And Multi-Omics Markers Reveal The Potential Role Of Nutrient-Gene Interaction In Anorexia Nervosa

Pierre Magistretti, Jiangyan Yang

Elsevier Science Bv2017

A preclinical model for identifying rats at risk of alcohol use disorder

Pierre Magistretti, Benjamin Boutrel

Alcohol use is one of the world's leading causes of death and disease, although only a small proportion of individuals develop persistent alcohol use disorder (AUD). The identification of vulnerable individuals prior to their chronic intoxication remains o ...

Springer Nature2017

Lack of PTG involvement in glycogen regulation during sleep deprivation in mice

Pierre Magistretti, Igor Allaman, Jean-Marie Petit, Gabriele Grenningloh, Sophie Burlet Godinot, Evelyne Ruchti, Jin Teng Chung

Wiley2017

Neuron-glia metabolic coupling: role in neuronal plasticity, memory and neuroprotection

Pierre Magistretti

Wiley2017

Regulation Of Neuron-Astrocyte Metabolic Coupling Across The Sleep-Wake Cycle

Pierre Magistretti, Jean-Marie Petit

Over the last thirty years, a growing number of studies showed that astrocytes play a pivotal role in the energy support to synapses. More precisely, astrocytes adjust energy production to neuronal energy needs through different mechanisms grouped under th ...

Elsevier2016

Glutamate Cysteine Ligase-Modulatory Subunit Knockout Mouse Shows Normal Insulin Sensitivity but Reduced Liver Glycogen Storage

Pierre Magistretti, Kim Do

Glutathione (GSH) deficits have been observed in several mental or degenerative illness, and so has the metabolic syndrome. The impact of a decreased glucose metabolism on the GSH system is well-known, but the effect of decreased GSH levels on the energy m ...

Frontiers Media Sa2016

Improvement of Neuroenergetics by Hypertonic Lactate Therapy in Patients with Traumatic Brain Injury Is Dependent on Baseline Cerebral Lactate/Pyruvate Ratio

Pierre Magistretti, Reto Meuli, Luc Pellerin

Energy dysfunction is associated with worse prognosis after traumatic brain injury (TBI). Recent data suggest that hypertonic sodium lactate infusion (HL) improves energy metabolism after TBI. Here, we specifically examined whether the efficacy of HL (3h i ...

Mary Ann Liebert2016

The Subjective Sensation of Synchrony: An Experimental Study

Pierre Magistretti, Delphine Preissmann, Joan Llobera Mahy

People performing actions together have a natural tendency to synchronize their behavior. Consistently, people doing a task together build internal representations not only of their actions and goals, but also of the other people performing the task. Howev ...

Public Library of Science2016

Dysregulation of soluble epoxide hydrolase and lipidomic profiles in anorexia nervosa

Pierre Magistretti, Jiangyan Yang

Individuals with anorexia nervosa (AN) restrict eating and become emaciated. They tend to have an aversion to foods rich in fat. Because epoxide hydrolase 2 (EPHX2) was identified as a novel AN susceptibility gene, and because its protein product, soluble ...

Nature Publishing Group2016

A Role for Lactate in the Consolidation of Drug-Related Associative Memories

Pierre Magistretti, Benjamin Boutrel

Elsevier2016

Sleep fragmentation alters brain energy metabolism without modifying hippocampal electrophysiological response to novelty exposure

Pierre Magistretti, Jean-Marie Petit, Maxime Olivier Baud

Sleep is viewed as a fundamental restorative function of the brain, but its specific role in neural energy budget remains poorly understood. Sleep deprivation dampens brain energy metabolism and impairs cognitive functions. Intriguingly, sleep fragmentatio ...

Wiley-Blackwell2016

Page 2 of 9