Publications by Antoine Dorcier

Studies on the reactivity of organometallic Ru-, Rh- and Os-pta complexes with DNA model compounds

Rosario Scopelliti, Paul Joseph Dyson, Antoine Dorcier, Christian Hartinger

The reactions of arene-metal complexes (arene = p-cymene, benzene or pentamethylcyclopentadienyl, metal = Ru, Rh or Os), including 1,3,5-triaza-7-phosphatricyclo-[3.3.1.1]decanephosphine (pta) and chloro co-ligands, with 9-methylguanine, adenine, and a ser ...

2008

pKa Estimation of Ruthenium(II)-Arene PTA Complexes and their Hydrolysis Products via a DFT/Continuum Electrostatics Approach

Paul Joseph Dyson, Ursula Röthlisberger, Antoine Dorcier, Christian Gossens

A combined d. functional theory/continuum electrostatics approach was used to est. the pKa values of metal-based compds. and their hydrolysis products. Specifically, the protonation states and abs. pKa values of [M(h6-arene)(X)(Y)(pta)]n+ (M = Ru or Os; ar ...

2007

Aqueous phase carbon dioxide and bicarbonate hydrogenation catalyzed by cyclopentadienyl ruthenium complexes

Gabor Laurenczy, Paul Joseph Dyson, Antoine Dorcier

The water-sol. ruthenium(II) complexes [Cp'RuX(PTA)2]Y and [CpRuCl(PPh3)(mPTA)]OTf (Cp' = Cp, Cp*, X = Cl and Y = nil; or X = MeCN and Y = PF6; PTA = 1,3,5-triaza-7-phosphaadamantane; mPTA = 1-methyl-1,3,5-triaza-7-phosphaadamantane) were used as catalyst ...

2007

In Vitro Evaluation of Rhodium and Osmium RAPTA Analogues: The Case for Organometallic Anticancer Drugs Not Based on Ruthenium

Gabor Laurenczy, Paul Joseph Dyson, Antoine Dorcier, Wee Han Ang, Andrew Douglas Phillips

Reaction of the dimer [(η5-C5Me5)RhCl(μ2-Cl)]2 with 2 or 4 equiv of the water-soluble phosphine 1,3,5-triaza-7-phosphatricyclo[3.3.1.1]decane (pta) affords [Rh(η5-C5Me< ...

2006

Influence of Hydrogen-Bonding Substituents on the Cytotoxicity of RAPTA Compounds

Sébastien Rochat, Paul Joseph Dyson, Ursula Röthlisberger, Ivano Tavernelli, Antoine Dorcier, Christian Gossens, Claudine Scolaro, Gianni Sava

A new series of organometallic ruthenium(II)-arene compounds of the type RuCl2(η6-arene)(phosphine) (phosphine = 1,3,5-triaza-7-phosphaadamantane, PTA, and 3,7-diacetly-1,3,7-triaza-5-phosphabicyclo[3.3.1]nonane, DAPTA) with different ...

2006

Ru(II), Os(II) and RH(III) complexes of PTA : their reactivity towards nucleotides and oligonucleotides

Antoine Dorcier

A series of ruthenium, osmium and rhodium complexes utilizing pta, (1,3,5-triaza-7-phosphatricyclo-[3.3.1.1]decane) and pta-Me+, its N-methyl derivative, have been synthesized. Their characterization by 1H and 31P NMR spectroscopy, ESI-MS and single crysta ...

EPFL2006

Binding of Organometallic Ruthenium(II) and Osmium(II) Complexes to an Oligonucleotide: A Combined Mass Spectrometric and Theoretical Study

Rosario Scopelliti, Paul Joseph Dyson, Ursula Röthlisberger, Ivano Tavernelli, Antoine Dorcier, Christian Gossens

Ru(II) and Os(II) p-cymene dichloride complexes with either a pta (1,3,5-triaza-7-phosphatricyclo[3.3.1.1]decane) or [pta-Me]Cl ligand which exhibit anticancer activity were prepd. and characterized by 1H and 31P NMR spectroscopy and mass spectrometry. Thr ...

2005

Development of organometallic (organo-transition metal) pharmaceuticals

Paul Joseph Dyson, Antoine Dorcier, Claudine Scolaro, Claire Samantha Allardyce

This paper is aimed at introducing the organometallic chemist to the fascinating area of organometallic pharmaceuticals. It commences by identifying the properties of organometallic (transition metal) compounds that lend themselves to medical applications. ...

2005