Publications by Conlin O'Neil | EPFL Graph Search

Cytoplasmic Stopped Flow at the Single Cell Level Based on Photosensitive Polymersomes

Jeffrey Alan Hubbell, Conlin O'Neil, Demetri Psaltis, Andreas Vasdekis

Cell Press2014

Polymer micelles with pyridyl disulfide-coupled antigen travel through lymphatics and show enhanced cellular responses following immunization

Jeffrey Alan Hubbell, Melody Swartz, Conlin O'Neil, Jackson Eby, Sachiko Hirosue, Karen Dane

Poly(ethylene glycol)-stabilized poly(propylene sulfide) core (PEG-PPS) nanoparticles (NPs) smaller than 50 nm efficiently travel to draining lymph nodes and interact with antigen-presenting cells (APCs) to induce potent immune responses following intrader ...

Elsevier Sci Ltd2012

Precision Intracellular Delivery Based on Optofluidic Polymersome Rupture

Jeffrey Alan Hubbell, Conlin O'Neil, Demetri Psaltis, Andreas Vasdekis

We present an optical approach for intracellular delivery of molecules contained within oxidation-sensitive polymersomes. The photosensitizer ethyl eosin is associated with the polymersome membrane to oxidatively increase the hydrophilicity of the hydropho ...

American Chemical Society2012

Nano-sized drug-loaded micelles deliver payload to lymph node immune cells and prolong allograft survival

Jeffrey Alan Hubbell, Melody Swartz, Conlin O'Neil, Alice Anna Tomei, Jackson Eby, Karen Dane

By delivering immunomodulatory drugs in vivo directly to lymph nodes draining an injection site, an opportunity exists to increase drug bioavailability to local immune cells. Importantly, particles smaller than 100 nm are efficiently transported through ly ...

Elsevier2011

Analytical ultracentrifugation to support the development of biomaterials and biomedical devices

Jutta Christine Wandrey, Jeffrey Alan Hubbell, Conlin O'Neil, Urara Hasegawa

Analytical ultracentrifugation (AUC) primarily serves to investigate hydrodynamic and thermodynamic properties of natural and synthetic macromolecules and colloids in solution, dispersion or suspension. Beside such more conventional use, AUC can support ma ...

2011

Enzymatic- and temperature-sensitive controlled release of ultrasmall superparamagnetic iron oxides (USPIOs)

Jeffrey Alan Hubbell, Conlin O'Neil

Background: Drug and contrast agent delivery systems that achieve controlled release in the presence of enzymatic activity are becoming increasingly important, as enzymatic activity is a hallmark of a wide array of diseases, including cancer and atheroscle ...

2011

Enzymatic- and temperature-sensitive controlled release of ultrasmall superparamagnetic iron oxides (USPIOs) (vol 9, pg 7, 2011)

Jeffrey Alan Hubbell, Conlin O'Neil

2011

Synthesis of Pyridyl Disulfide-Functionalized Nanoparticles for Conjugating Thiol-Containing Small Molecules, Peptides, and Proteins

Jeffrey Alan Hubbell, Conlin O'Neil, Urara Hasegawa

Previously we reported emulsion polymerization of propylene sulfide with Pluronic F127 as an emulsifier, yielding nanoparticles (NPs) in the 25 nm size range. Immunologically functional NPs were prepared by adding an antigen Pluronic conjugate to the polym ...

2010

Block copolymers and uses thereof

Jeffrey Alan Hubbell, Melody Swartz, Conlin O'Neil

An encoding/decoding apparatus and method using a low-density parity-check code (LDPC code) is disclosed. Basic column group information, serving as a set of information regarding positions of rows with weight 1, is extracted from a reference column in eac ...

2010

Assessing the Role of Poly(ethylehe glycol-bl-propylene sulfide) (PEG-PPS) Block Copolymers in the Preparation of Carbon Nanotube Biocompatible Dispersions

Jeffrey Alan Hubbell, Conlin O'Neil, Davide Demurtas

Amphiphilic block copolymers based on hydrophobic polysulfides (poly(propylene sulfide), PPS) and hydrophilic polyethers (poly(ethylene glycol), PEG) have been used to solubilize and disperse single-walled carbon nanotubes (SWNTs). The obtained highly conc ...

American Chemical Society2010

Nanoparticles for immunotherapy

Jeffrey Alan Hubbell, Melody Swartz, Conlin O'Neil, Sai Reddy, Eleonora Simeoni

Nanoparticles that activate complement in the absence of biological molecules are described. The nanoparticles are shown to specifically target antigen presenting cells in specifically in lymph nodes, without the use of a biological molecule for targeting. ...

2010

A Novel Method for the Encapsulation of Biomolecules into Polymersomes via Direct Hydration

Jeffrey Alan Hubbell, Conlin O'Neil, Andrija Finka, Davide Demurtas

One of the major engineering challenges for the implementation of block copolymer vesicles, or polymersomes, as therapeutic drug carriers is obtaining high encapsulation efficiencies for biomolecules. Here we present it novel method for encapsulation of pr ...

2009

Aggregation Behavior of Poly(ethylene glycol-bl-propylene sulfide) Di- and Triblock Copolymers in Aqueous Solution

Jacques Dubochet, Jeffrey Alan Hubbell, Conlin O'Neil

Block copolymers of poly(ethylene glycol)-bl-poly(propylene sulfide) (PEG-PPS) have recently emerged as a new macromolecular amphiphile capable of forming a wide range of morphologies when dispersed in water. To understand better the relationship between s ...

2009

Novel applications of poly(ethylene glycol)-bl-poly(propylene sulfide) block copolymers

Conlin O'Neil

Block copolymers are comprised of repeating chemical groups (blocks) which commonly contain at least one hydrophilic block coupled to at least one hydrophobic block, forming an amphipathic macromolecule. This molecular arrangement drives the self assembly ...

EPFL2008

Biofunctional polymer nanoparticles for intra-articular targeting and retention in cartilage

Jeffrey Alan Hubbell, Conlin O'Neil, Dominique André Rothenfluh

The extracellular matrix of dense, avascular tissues presents a barrier to entry for polymer-based therapeutics, such as drugs encapsulated within polymeric particles. Here, we present an approach by which polymer nanoparticles, suffciently small to enter ...

Nature Publishing Group2008

Superparamagnetic Nanoparticles as a Powerful Systems Biology. Characterization Tool in the Physiological Context

Heinrich Hofmann, Alke Fink, Jeffrey Alan Hubbell, Benedikt Steitz, Conlin O'Neil, Marc Moniatte, Andrija Finka, Jatuporn Salaklang

Recently, functionalized superparamagnetic iron oxide nanoparticles (SPIONs) have been utilized for protein separation and therapeutic delivery of DNA and drugs. The development of new methods and tools for the targeting and identification of specific biom ...

Wiley-Blackwell2008