Publications by Tyler Nerton Thacher

Real-time Full Field Laser Doppler Imaging

Marcel Leutenegger, Theo Lasser, Tyler Nerton Thacher

We present a full field laser Doppler imaging instrument that enables real-time in vivo assessment of blood flow in dermal tissue and skin. The instrument monitors the blood perfusion in an area of about 50cm2 with 480 x 480 pixels per frame at a rate of 1 ...

Amer Inst Physics2012

Real-time full field laser Doppler imaging

Marcel Leutenegger, Theo Lasser, Antonio Lopez, Tyler Nerton Thacher, Erica Martin-Williams

We present a full field laser Doppler imaging instrument, which enables real-time in vivo assessment of blood flow in dermal tissue and skin. This instrument monitors the blood perfusion in an area of about 50 cm² with 480 × 480 pixels per frame at a rate ...

2011

Differential effects of reduced cyclic stretch and perturbed shear stress within the arterial wall

Tyler Nerton Thacher

Due to the pulsatile nature of blood flow, arteries are constantly exposed to dynamic mechanical forces; the pulsatility continuously stretches the vessel wall and the flow creates a frictional force on the interior surface. These stresses, referred to as ...

EPFL2009

Autonomous effects of shear stress and cyclic circumferential stretch regarding endothelial dysfunction and oxidative stress: an ex vivo arterial model

Nikolaos Stergiopoulos, Paolo Silacci, Tyler Nerton Thacher, Rafaela Fernandes Da Silva

Cyclic circumferential stretch and shear stress caused by pulsatile blood flow work in concert, yet are very different stimuli capable of independently mediating endothelial function by modulating eNOS expression, oxidative stress (via production of supero ...

American Soc Mechanical Engineers, Three Park Avenue, New York, Ny 10016-5990 Usa2009

Micelles for delivery of nitric oxide

Nikolaos Stergiopoulos, Jeffrey Alan Hubbell, Simone Cavadini, Yun Suk Jo, Jay Gantz, Tyler Nerton Thacher, Davide Demurtas

We designed block copolymer pro-amphiphiles and amphiphiles for providing very long-term release of nitric oxide (NO). A block copolymer of N-acryloylmorpholine (AM, as a hydrophile) and N-acryloyl-2,5-dimethylpiperazine (AZd, as a hydrophilic precursor) w ...

2009

Arterial biomechanics after destruction of cytoskeleton by Cytochalasin D

Nikolaos Stergiopoulos, Paolo Silacci, Sylvain Roy, Tyler Nerton Thacher

Vascular smooth muscle is a major structural element of the arterial wall. We examined the effects of cytoskeleton destruction, after administration of Cytochalasin D, on the biomechanical properties of porcine common carotids. Compared to untreated, maxim ...

2009

Differential effects of reduced cyclic stretch and perturbed shear stress within the arterial wall and on smooth muscle function

Nikolaos Stergiopoulos, Tyler Nerton Thacher, Rafaela Fernandes Da Silva

Cyclic circumferential stretch and shear stress act in concert and yet are capable of independently mediating arterial smooth muscle function, modulating the production of superoxide and stimulating arterial remodeling. ...

Oxford University Press2009

Reduced cyclic stretch, endothelial dysfunction, and oxidative stress: an ex vivo model

Nikolaos Stergiopoulos, Veronica Gambillara, Paolo Silacci, Tyler Nerton Thacher, Rafaela Fernandes Da Silva

The objective of this study was to investigate whether reduction of cyclic circumferential stretch will impair endothelial function and elevate basal levels of oxidative stress, both known risk factors linked to cardiovascular disease. ...

2009

Regulation of arginase pathway in response to wall shear stress

Nikolaos Stergiopoulos, Veronica Gambillara, Paolo Silacci, Fabienne Riche, Tyler Nerton Thacher, Rafaela Fernandes Da Silva

Alterations of wall shear stress can predispose the endothelium to the development of atherosclerotic plaques. Ample evidence indicates that arginase expression and/or activity correlates with several risk factors for cardiovascular disease including ather ...

2009

Effects Of Reduced Compliance On Endothelial Functionality With Regards To Inflammation

Nikolaos Stergiopoulos, Veronica Gambillara, Paolo Silacci, Tyler Nerton Thacher, Rafaela Fernandes Da Silva

American Soc Mechanical Engineers, Three Park Avenue, New York, Ny 10016-5990 Usa2009

Effects of reduced cyclic stretch on vascular smooth muscle cell function of pig carotids perfused ex vivo

Nikolaos Stergiopoulos, Veronica Gambillara, Paolo Silacci, Tyler Nerton Thacher

With advancing age arteries stiffen, reducing arterial compliance and leading to the development of systolic hypertension and to a substantial increase in pulse pressure. An augmented pulse pressure can be a predictor of the development of hypertension, wh ...

Oxford University Press2008

Oscillatory shear stress and reduced compliance impair vascular functions

Nikolaos Stergiopoulos, Veronica Gambillara, Paolo Silacci, Tyler Nerton Thacher, Rafaela Fernandes Da Silva

Shear stress has been shown to influence endothelial cell gene expression and morphology. In particular, low and bi-directional shear stress, mimicking conditions at plaque-prone areas, down-regulates the expression of several atheroprotective genes, and u ...

2007