Publications by Sonia Verp | EPFL Graph Search

DUX is a non-essential synchronizer of zygotic genome activation

Didier Trono, Sonia Verp, Sandra Eloise Kjeldsen, Alberto De Iaco, Delphine Yvette L Grun

Some of the earliest transcripts produced in fertilized human and mouse oocytes code for DUX, a double homeodomain protein that promotes embryonic genome activation (EGA). Deleting Dux by genome editing at the 1- to 2-cell stage in the mouse impairs EGA an ...

2019

DUX-family transcription factors regulate zygotic genome activation in placental mammals

Didier Trono, Sonia Verp, Julien Léonard Duc, Andrea Coluccio, Alberto De Iaco, Evaristo Jose Planet Letschert

In animal embryos, transcription is mostly silent for several cell divisions, until the release of the first major wave of embryonic transcripts through so-called zygotic genome activation (ZGA). Maternally provided ZGA-triggering factors have been identif ...

2017

Control of mitophagie by microRNAs - A key step of erythropoiesis

Didier Trono, Isabelle Barde, Sonia Verp, Andrea Corsinotti, Jiri Vanicek, Sandra Eloise Kjeldsen, Adamantia Kapopoulou, Ray Marcel Marin Florez, Benjamin Rauwel

Edp Sciences S A2014

De novo DNA methylation of endogenous retroviruses is shaped by KRAB-ZFPs/KAP1 and ESET

Didier Trono, Sonia Verp, Helen Mary Rowe, Marc Samuel Friedli, Sandra Eloise Kjeldsen

Endogenous retroviruses (ERVs) undergo de novo DNA methylation during the first few days of mammalian embryogenesis, although the factors that control the targeting of this process are largely unknown. We asked whether KAP1 (KRAB-associated protein 1) is i ...

Company Of Biologists Ltd2013

A KRAB/KAP1-miRNA Cascade Regulates Erythropoiesis Through Stage-Specific Control of Mitophagy

Didier Trono, Isabelle Barde, Sonia Verp, Andrea Corsinotti, Jiri Vanicek, Sandra Eloise Kjeldsen, Adamantia Kapopoulou, Ray Marcel Marin Florez, Benjamin Rauwel

During hematopoiesis, lineage- and stage-specific transcription factors work in concert with chromatin modifiers to direct the differentiation of all blood cells. Here, we explored the role of KRAB-containing zinc finger proteins (KRAB-ZFPs) and their cofa ...

American Association for the Advancement of Science2013

Efficient sperm cryopreservation and recovery of mouse lines from various backgrounds

Isabelle Barde, Sonia Verp, Sandra Eloise Kjeldsen, Xavier Warot, Michelle Blom

Springer2013

Measuring In Vivo Protein Half-Life

Kai Johnsson, Christian Heinis, Didier Trono, Isabelle Barde, Sonia Verp, Karolina Bojkowska, Francesca Santoni de Sio, Sandra Eloise Kjeldsen

Protein turnover critically influences many biological functions, yet methods have been lacking to assess this parameter in vivo. Here, we demonstrate how chemical labeling of SNAP-tag fusion proteins can be exploited to measure the half-life of resident i ...

Elsevier2011

KAP1 controls endogenous retroviruses in embryonic stem cells

Didier Trono, Daniel Constam, Pierre Maillard, Séverine Reynard, Johan Jakobsson, Sonia Verp, Helen Mary Rowe, Jacques Rougemont, Hillary Layard-Liesching

More than forty per cent of the mammalian genome is derived from retroelements, of which about one-quarter are endogenous retroviruses (ERVs). Some are still active, notably in mice the highly polymorphic early transposon (ETn)/MusD and intracisternal A-ty ...

Nature Publishing Group2010

Regulation of Episomal Gene Expression by KRAB/KAP1-Mediated Histone Modifications

Patrick Aebischer, Vivianne Padrun, Christopher Towne, Didier Trono, Isabelle Barde, Sonia Verp, Anna Claire Groner

KAP1 is an essential cofactor of KRAB zinc finger proteins, a family of vertebrate-specific epigenetic repressors of largely unknown functions encoded in the hundreds by the mouse and human genomes. So far, KRAB/KAP1-mediated gene regulation has been studi ...

American Society for Microbiology2009

APOBEC3-independent interferon-induced viral clearance in hepatitis B virus transgenic mice

Didier Trono, Priscilla Turelli, Bastien Mangeat, Stéphanie Jost, Sonia Verp

Interferon (IFN) has been part of the standard treatment of chronic hepatitis B infection for more than 2 decades, yet the mechanism of action of this antiviral remains poorly understood. It was recently observed that members of the human APOBEC family of ...

American Society for Microbiology2008