Publications by Michael Vincent Frochaux

Extensive tissue-specific expression variation and novel regulators underlying circadian behavior

Michael Vincent Frochaux, Bart Deplancke, Matteo Dal Peraro, Antonio Carlos Alves Meireles Filho, Roel Paulus Josephus Bevers, Alessio Prunotto, Julie Marie Russeil, Virginie Sandra Braman, Vincent Roland Julien Gardeux, Maria Litovchenko, Brian Dennis Hollis

Natural genetic variation affects circadian rhythms across the evolutionary tree, but the underlying molecular mechanisms are poorly understood. We investigated population-level, molecular circadian clock variation by generating >700 tissue-specific transc ...

2021

cis-regulatory variation modulates susceptibility to enteric infection in the Drosophila genetic reference panel

Michael Vincent Frochaux, Bart Deplancke, Dani Osman, Maroun Bou Sleiman, Tommaso Andreani, Riccardo Dainese, Virginie Sandra Braman, Vincent Roland Julien Gardeux, Maria Litovchenko, Brian Dennis Hollis

Background: Resistance to enteric pathogens is a complex trait at the crossroads of multiple biological processes. We have previously shown in the Drosophila Genetic Reference Panel (DGRP) that resistance to infection is highly heritable, but our understan ...

2020

Enteric infection induces Lark-mediated intron retention at the 5 ' end of Drosophila genes

Michael Vincent Frochaux, Bart Deplancke, Dani Osman, Maroun Bou Sleiman, Tommaso Andreani

Background RNA splicing is a key post-transcriptional mechanism that generates protein diversity and contributes to the fine-tuning of gene expression, which may facilitate adaptation to environmental challenges. Here, we employ a systems approach to study ...

2020

Inter-embryo gene expression variability recapitulates the hourglass pattern of evo-devo

Michael Vincent Frochaux, Bart Deplancke, Vincent Roland Julien Gardeux

Background The evolution of embryological development has long been characterized by deep conservation. In animal development, the phylotypic stage in mid-embryogenesis is more conserved than either early or late stages among species within the same phylum ...

2020

Multilevel regulation of the glass locus during Drosophila eye development

Michael Vincent Frochaux, Bart Deplancke, Abhishek Kumar Mishra

Development of eye tissue is initiated by a conserved set of transcription factors termed retinal determination network (RDN). In the fruit fly Drosophila melanogaster, the zinc-finger transcription factor Glass acts directly downstream of the RDN to contr ...

2019

Elucidating regulatory mechanisms shaping the transcriptome and proteome of the gut immune response in Drosophila melanogaster

Michael Vincent Frochaux

Work on Drosophila melanogaster paved the way to our current understanding of modern genetics. Since then, this model organism has contributed greatly to various fields such as neurobiology, development, and immunology. The discovery and analysis of the va ...

EPFL2019

Commensal Gut Bacteria Buffer the Impact of Host Genetic Variants on Drosophila Developmental Traits under Nutritional Stress

Michael Vincent Frochaux, Bart Deplancke, Maroun Bou Sleiman, Virginie Sandra Braman, Maria Litovchenko

Eukaryotic genomes encode several buffering mechanisms that robustly maintain invariant phenotypic outcome despite fluctuating environmental conditions. Here we show that the Drosophila gut-associated commensals, represented by a single facultative symbion ...

2019

Tetracyclines Disturb Mitochondrial Function across Eukaryotic Models: A Call for Caution in Biomedical Research

Michael Vincent Frochaux, Bart Deplancke, Johan Auwerx, Richardus Houtkooper, Norman Lionel Moullan, Evan Graehl Williams, Dongryeol Ryu, Adrienne Joëlle Laurence Mottis, Laurent Mouchiroud, Virginija Jovaisaite, Xu Wang

In recent years, tetracyclines, such as doxycycline, have become broadly used to control gene expression by virtue of the Tet-on/Tet-off systems. However, the wide range of direct effects of tetracycline use has not been fully appreciated. We show here tha ...

Elsevier2015

An evolutionarily conserved role for the aryl hydrocarbon receptor in the regulation of movement

Michael Vincent Frochaux, Bart Deplancke, Johan Auwerx, Pénélope Andreux, Evan Graehl Williams, Laurent Mouchiroud

The BXD genetic reference population is a recombinant inbred panel descended from crosses between the C57BL/6 (B6) and DBA/2 (D2) strains of mice, which segregate for about 5 million sequence variants. Recently, some of these variants have been established ...

Public Library of Science2014