Publications by Pedro Romero | EPFL Graph Search

Tumor-specific cytolytic CD4 T cells mediate immunity against human cancer

David Gfeller, Georg Alexander Rockinger, Pedro Romero, Amélie Cachot, Hatice Altug, Margaux Saillard, Xiaokang Li, George Coukos, Yen-Cheng Liu, Alexandre Harari, Alexander Mathis

CD4 T cells have been implicated in cancer immunity for their helper functions. Moreover, their direct cytotoxic potential has been shown in some patients with cancer. Here, by mining single-cell RNA-seq datasets, we identified CD4 T cell clusters displayi ...

2021

Enhanced Phenotype Definition for Precision Isolation of Precursor Exhausted Tumor-Infiltrating CD8 T Cells

Pedro Romero, Amaia Martinez Usatorre

In the context of adoptive T cell transfer (ACT) for cancer treatment, it is crucial to generate in vitro large amounts of tumor-specific CD8 T cells with high potential to persist in vivo. PD-1, Tim3, and CD39 have been proposed as markers of tumor-specif ...

2020

Tumor-Specific Cytolytic Cd4 T Cells Mediate Protective Immunity Against Human Cancer

David Gfeller, Pedro Romero, Amélie Cachot, Hatice Altug, Margaux Saillard, Xiaokang Li, George Coukos, Yen-Cheng Liu, Alexandre Harari, Alexander Mathis

BMJ PUBLISHING GROUP2020

The NAD-Booster Nicotinamide Riboside Potently Stimulates Hematopoiesis through Increased Mitochondrial Clearance

Matthias Lütolf, Yannick Lionel Yersin, Vincent Trachsel, Bart Deplancke, Nicola Vannini, Johan Auwerx, Pedro Romero, Carlos Canto Alvarez, Martin Ehrbar, Mukul Girotra, Aurélien Laurent Jean-Charles Oggier, Dongryeol Ryu, Eija Riitta Pirinen, Olaia Maria Naveiras Torres-Quiroga, Pernille Yde Rainer, Gennady Nikitin, Vasco Ledebur de Antas de Campos, Joanna Ratajczak, Loïc Tauzin, Josefine Catharina Pedersen Tratwal, Federico Sizzano, George Coukos, Sonja Giger, Shanti Rojas-Sutterlin, Yang Li, Simone Ragusa

It has been recently shown that increased oxidative phosphorylation, as reflected by increased mitochondrial activity, together with impairment of the mitochondrial stress response, can severely compromise hematopoietic stem cell (HSC) regeneration. Here w ...

CELL PRESS2019

Piezoresistive Membrane Surface Stress Sensors for Characterization of Breath Samples of Head and Neck Cancer Patients

Frédéric Loizeau, Pedro Romero, Terunobu Akiyama, Christoph Gerber

For many diseases, where a particular organ is affected, chemical by-products can be found in the patient's exhaled breath. Breath analysis is often done using gas chromatography and mass spectrometry, but interpretation of results is difficult and time-co ...

Mdpi Ag2016

Enhancing Efficacy of Anticancer Vaccines by Targeted Delivery to Tumor-Draining Lymph Nodes

Jeffrey Alan Hubbell, Melody Swartz, Alexandre de Titta, Marie Ballester, Patricia Corthésy Henrioud, Pedro Romero, Laura Jeanbart

The sentinel or tumor-draining lymph node (tdLN) serves as a metastatic niche for many solid tumors and is altered via tumor-derived factors that support tumor progression and metastasis. tdLNs are often removed surgically, and therapeutic vaccines against ...

Amer Assoc Cancer Research2014

Insights into the thermo-mechanics of orthogonal nanometric machining

Jean-François Molinari, Guillaume Anciaux, Pedro Romero

The fabrication of high precision miniaturized components in micro- and nano-technologies requires a deep understanding of the physical mechanisms governing the nanomachining process. To aid with this need, the current article employs molecular dynamics to ...

Elsevier2013

Regulation of Monocyte Functional Heterogeneity by miR-146a and Relb

Martin Etzrodt, Pedro Romero, Etienne Meylan

Monocytes serve as a central defense system against infection and injury but can also promote pathological inflammatory responses. Considering the evidence that monocytes exist in at least two subsets committed to divergent functions, we investigated wheth ...

Elsevier2012

Friction at the tool-chip interface during orthogonal nanometric machining

Jean-François Molinari, Guillaume Anciaux, Pedro Romero

Understanding the unfolding of friction between the tool and the generated chip is of fundamental importance to nanometric machining processes. To this end, this paper investigates the influence of tool geometry, lattice orientation, machining velocity and ...

2012

Exhaustion of tumor-specific CD8(+) T cells in metastases from melanoma patients

Nathalie Rufer, Lukas Baitsch, Bart Deplancke, Pedro Romero, Sunil Kumar Raghav

In chronic viral infections, CD8(+) T cells become functionally deficient and display multiple molecular alterations. In contrast, only little is known of self- and tumor-specific CD8(+) T cells from mice and humans. Here we determined molecular profiles o ...

American Society for Clinical Investigation2011

Evidence for a TCR Affinity Threshold Delimiting Maximal CD8 T Cell Function

Olivier Michielin, Nathalie Rufer, Pedro Romero

Protective adaptive immune responses rely on TCR-mediated recognition of Ag-derived peptides presented by self-MHC molecules. However, self-Ag (tumor)-specific TCRs are often of too low affinity to achieve best functionality. To precisely assess the relati ...

American Association of Immunologists ; Oxford University Press2010

Study of Nanometric Machining in Crystalline Solids Using Molecular Dynamics

Jean-François Molinari, Guillaume Anciaux, Pedro Romero

Due to the current interest in nanotechnology, there is a strong desire for comprehensive knowledge on the underlying mechanisms governing the nanometric machining process. This article employs molecular dynamics to study nanomachining in ductile crystalli ...

2010

Numerical simulations of nanotribology

Jean-François Molinari, Guillaume Anciaux, Pedro Romero

We present a 3D multiscale coupling method to address sliding contact simulations at the nanoscale. The components of the model are a molecular dynamics engine, a finite element program and a coupling scheme. We consider the normal loading of a rough (frac ...

2009