Publications by Tom Hilbert | EPFL Graph Search

Triangular Fibrocartilage Characterization with Ultrashort Echo Time-T2* MRI: Insights from a Healthy Cohort

The objective of this study is to measure T2* relaxation time in the triangular fibrocartilage (TFC) disc in asymptomatic volunteers and evaluate its variation with factors such as age, hand dominance, sex, and ulnar variance, using a dedicated MRI sequenc ...

2025

Individually optimized dynamic parallel transmit pulses for 3D high‐resolution SPACE imaging at 7T

Bénédicte Marie Maréchal, Tom Hilbert, Jocelyn Philippe, Thomas Yu

Purpose: Although clinical 7T MRI offers various advantages compared to lower field strengths, achieving spatially uniform flip angle distributions remains a challenge. Sampling Perfection with Application optimized Contrast using different flip angle Evol ...

Wiley2025

Feasibility of Qualitative Evaluation and Quantitative T2 Mapping of Peripheral Nerves and Muscles Using GRAPPATINI

Tom Hilbert

BackgroundQuantitative T2 mapping holds promise for evaluating peripheral nerve and muscle disorders, but current methods lack speed and diagnostic feasibility. As a proof of concept, T2 mapping may be applied to assess the abnormality of the common perone ...

WILEY2025

To evaluate repaired rotator cuff morphologically and quantitatively in one GRAPPATINI MRI examination

Tobias Kober, Tom Hilbert

Background: GRAPPATINI is capable of originating synthetic T2 images (T2(synth)) and T2 maps in one magnetic resonance imaging (MRI) scan. Purpose: To evaluate GRAPPATINI's performance in providing simultaneous morphological assessment of repaired rotator ...

SAGE PUBLICATIONS LTD2025

Precision brain morphometry using cluster scanning

Tobias Kober, Tom Hilbert

Measurement error limits the statistical power to detect group differences and longitudinal change in structural MRI morphometric measures (e.g., hippocampal volume, prefrontal cortical thickness). Recent advances in scan acceleration enable extremely fast ...

2024

Value of MRI-T2 Mapping to Differentiate Clinically Significant Prostate Cancer

Tom Hilbert

Standardized reporting of multiparametric prostate MRI (mpMRI) is widespread and follows international standards (Pi-RADS). However, quantitative measurements from mpMRI are not widely comparable. Although T2 mapping sequences can provide repeatable quanti ...

SPRINGER2024

Quantifying brain development in the HEALthy Brain and Child Development (HBCD) Study: The magnetic resonance imaging and spectroscopy protocol

Tobias Kober, Tom Hilbert

The HEALthy Brain and Child Development (HBCD) Study, a multi-site prospective longitudinal cohort study, will examine human brain, cognitive, behavioral, social, and emotional development beginning prenatally and planned through early childhood. The acqui ...

ELSEVIER SCI LTD2024

Advancing Thalamic Nuclei Segmentation: The Impact of Compressed Sensing on MRI Processing

Tobias Kober, Tom Hilbert

The thalamus is a collection of gray matter nuclei that play a crucial role in sensorimotor processing and modulation of cortical activity. Characterizing thalamic nuclei non-invasively with structural MRI is particularly relevant for patient populations w ...

Wiley2024

Normative volumes and relaxation times at 3T during brain development

Bénédicte Marie Maréchal, Tobias Kober, Tom Hilbert, Ricardo Alberto Corredor Jerez

While research has unveiled and quantified brain markers of abnormal neurodevelopment, clinicians still work with qualitative metrics for MRI brain investigation. The purpose of the current article is to bridge the knowledge gap between case-control cohort ...

Nature Portfolio2024

Quantitative T2 Mapping of Acute Pancreatitis

Tom Hilbert, Giulia Piazza

Background: Quantification of the T2 signal by means of T2 mapping in acute pancreatitis (AP) has the potential to quantify the parenchymal edema. Quantitative T2 mapping may overcome the limitations of previously reported scoring systems for reliable asse ...

Wiley2024

Multiparametric Characterization and Spatial Distribution of Different MS Lesion Phenotypes

Tobias Kober, Tom Hilbert, Gian Franco Piredda

BACKGROUND AND PURPOSE: MS lesions exhibit varying degrees of axonal and myelin damage. A comprehensive description of lesion phenotypes could contribute to an improved radiologic evaluation of smoldering inflammation and remyelination processes. This stud ...

Amer Soc Neuroradiology2024

Automated Quantitative Susceptibility and Morphometry MR Study: Feasibility and Interrelation Between Clinical Score, Lesion Load, Deep Grey Matter and Normal-Appearing White Matter in Multiple Sclerosis

Meritxell Bach Cuadra, Bénédicte Marie Maréchal, Tobias Kober, Tom Hilbert

Lesion load (LL), deep gray matter (DGM) and normal-appearing white matter (NAWM) susceptibility and morphometry may help in monitoring brain changes in multiple sclerosis (MS) patients. We aimed at evaluating the feasibility of a fully automated segmentat ...

2024

Perilesional tissue exhibits different T1 gradients depending on multiple sclerosis subtypes

Jean-Philippe Thiran, Bénédicte Marie Maréchal, Tobias Kober, Tom Hilbert, Veronica Lily Ravano

Sage Publications Ltd2023

Tract-wise microstructural analysis informs on current and future disability in early multiple sclerosis

Jean-Philippe Thiran, Bénédicte Marie Maréchal, Tobias Kober, Tom Hilbert, Veronica Lily Ravano

Objectives Microstructural characterization of patients with multiple sclerosis (MS) has been shown to correlate better with disability compared to conventional radiological biomarkers. Quantitative MRI provides effective means to characterize micro ...

Springer Heidelberg2023

Feasibility of accelerated T2 mapping for the preoperative assessment of endometrial carcinoma

Tobias Kober, Tom Hilbert

ObjectiveThe application value of T2 mapping in evaluating endometrial carcinoma (EMC) features remains unclear. The aim of the study was to determine the quantitative T2 values in EMC using a novel accelerated T2 mapping, and evaluate them for detection, ...

FRONTIERS MEDIA SA2023

Deep multiple sclerosis lesion phenotyping using multimodal quantitative MRI

Tobias Kober, Tom Hilbert, Gian Franco Piredda

Sage Publications Ltd2023

Synthetic Contrasts in Musculoskeletal MRI A Review

Tobias Kober, Tom Hilbert

This review summarizes the existing techniques and methods used to generate synthetic contrasts from magnetic resonance imaging data focusing on musculoskeletal magnetic resonance imaging. To that end, the different approaches were categorized into 3 diffe ...

LIPPINCOTT WILLIAMS & WILKINS2023

Morphological assessment of cartilage and osteoarthritis in clinical practice and research: Intermediate-weighted fat-suppressed sequences and beyond

Tom Hilbert

Magnetic resonance imaging (MRI) is widely regarded as the primary modality for the morphological assessment of cartilage and all other joint tissues involved in osteoarthritis. 2D fast spin echo fat-suppressed intermediate-weighted (FSE FS IW) sequences w ...

SPRINGER2023

Quantitative imaging through the production chain: from idea to application

Tom Hilbert

Springer2023

Clinical feasibility and validation of the accelerated T2 mapping sequence GRAPPATINI in brain imaging

Tom Hilbert

Rationale and objectives: To prospectively evaluate feasibility and robustness of an accelerated T2 mapping sequence (GRAPPATINI) in brain imaging and to assess its synthetic T2-weighted images (sT2w) in comparison with a standard T2-weighted sequence (T2 ...

CELL PRESS2023