Publications by Ulrike Kettenberger

The bile acid receptor TGR5 regulates the hematopoietic support capacity of the bone marrow niche

Dominique Pioletti, Kristina Schoonjans, Ulrike Kettenberger, Frédérica Schyrr, Alessia Perino, Alejandro Alonso Calleja, Antoine Jalil

Smw Supporting Association2023

Hydrogel Injection for a Rapid Local Bone Density Increase

Dominique Pioletti, Arne Christian Vogel, Ulrike Kettenberger

WILEY2022

Intraosseous Injection Of Hydrogel To Locally Increase Bone Density: Osteoporotic Hip Fracture Prevention As Potential Application

Dominique Pioletti, Ulrike Kettenberger

SPRINGER2022

Non-setting, injectable biomaterials containing particulate hydroxyapatite can increase primary stability of bone screws in cancellous bone

Dominique Pioletti, Jorge Solana Munoz, Ulrike Kettenberger

BACKGROUND: Fracture fixation in weak bone is still a clinical challenge. Screw augmentation was shown to successfully increase their primary stability. The currently used calcium phosphate or polymeric bone cements, however, present important drawbacks su ...

2018

Composition for bone regeneration

Dominique Pioletti, Ulrike Kettenberger

The composition for bone regeneration, comprises a) a first phase (3) comprising a plurality of cross-linked hydrogel chunks (1) having a mean diameter of less than 1000 μm and incorporating an amount of mineral particles (2); and b) a second phase (4) com ...

2017

In vitro and in vivo investigation of bisphosphonate-loaded hydroxyapatite particles for peri-implant bone augmentation

Dominique Pioletti, Ulrike Kettenberger

Locally applied bisphosphonates, such as Zoledronate, have been shown in several studies to inhibit peri-implant bone resorption and recently to enhance peri-implant bone formation. Studies have also demonstrated positive effects of hydroxyapatite particle ...

Wiley-Blackwell2017

Active Agent-Particle Combination Supporting Bone Regeneration

Dominique Pioletti, Ulrike Kettenberger

The invention provides for a bioactive composition comprising solid particles, such as e.g. calcium phosphate particles, loaded with an active agent, preferably an osteoconductive/osteoinductive agent or an anti-resorptive agent like a bisphosphonate. The ...

2017

Time course of bone screw fixation following a local delivery of zoledronate in a rat femoral model – a micro-finite element analysis

Dominique Pioletti, Alexandre Terrier, Ulrike Kettenberger, Adeliya Latypova

A good fixation of osteosynthesis implants is crucial for a successful bone healing but often difficult to achieve in osteoporotic patients. One possible solution to this issue is the local delivery of bisphosphonates in direct proximity to the implants, A ...

Elsevier2015

The role of energy dissipation of polymeric scaffolds in the mechanobiological modulation of chondrogenic expression

Dominique Pioletti, Philippe Abdel Sayed, Salim Elias Darwiche, Ulrike Kettenberger

Mechanical stimulation has been proposed to induce chondrogenesis in cell-seeded scaffold. However, the effects of mechanical stimuli on engineered cartilage may vary substantially between different scaffolds. This advocates for the need to identify an ove ...

2014

Does locally delivered Zoledronate influence peri-implant bone formation? – Spatio-temporal monitoring of bone remodeling in vivo

Dominique Pioletti, Julien Ston, Ulrike Kettenberger

Bisphosphonates are known for their strong inhibitory effect on bone resorption. Their influence on bone formation however is less clear. In this study we investigated the spatio-temporal effect of locally delivered Zoledronate on peri-implant bone formati ...

Elsevier2014

Energy dissipation as a mechanobiological variable inducing chondrogenesis

Dominique Pioletti, Ulrike Kettenberger

Wiley-Blackwell2014

Development of a Bisphosphonate Delivering Hydrogel for the Augmentation of Impaired Peri-Implant Bone

Ulrike Kettenberger

Osteoporosis is a major health problem in our aging society. This metabolic disease, which is characterized by a deterioration of the bone microarchitecture and a significant loss of bone mass, is affecting a rising number of mostly elderly patients. The m ...

EPFL2014

Development of a nano-composite drug eluting bone plug enhancing fixation of screws in low quality bone

Dominique Pioletti, Raphaël Rodolphe Obrist, Ulrike Kettenberger

Wiley-Blackwell2012