Publications by Istvan Bartha | EPFL Graph Search

Africa-specific human genetic variation near CHD1L associates with HIV-1 load

Jacques Fellay, Istvan Bartha, Christian Axel Wandall Thorball

HIV-1 remains a global health crisis(1), highlighting the need to identify new targets for therapies. Here, given the disproportionate HIV-1 burden and marked human genome diversity in Africa(2), we assessed the genetic determinants of control of set-point ...

NATURE PORTFOLIO2023

Functional characterization of 3D protein structures informed by human genetic diversity

Amalio Telenti, Julia di Iulio, Istvan Bartha

Sequence variation data of the human proteome can be used to analyze 3D protein structures to derive functional insights. We used genetic variant data from nearly 140,000 individuals to analyze 3D positional conservation in 4,715 proteins and 3,951 homolog ...

National Academy of Sciences2019

Correcting for Population Stratification Reduces False Positive and False Negative Results in Joint Analyses of Host and Pathogen Genomes

Jacques Fellay, Istvan Bartha, Christian Hammer, Nimisha Chaturvedi, Olivier Noël Marie Naret

2018

The human noncoding genome defined by genetic diversity

Julia di Iulio, Istvan Bartha

2018

Genome-to-genome analysis highlights the effect of the human innate and adaptive immune systems on the hepatitis C virus

David Smith, Jacques Fellay, Istvan Bartha, Nimisha Chaturvedi

Outcomes of hepatitis C virus (HCV) infection and treatment depend on viral and host genetic factors. Here we use human genome-wide genotyping arrays and new whole-genome HCV viral sequencing technologies to perform a systematic genome-to-genome study of 5 ...

Nature Publishing Group2017

Severe viral respiratory infections in children with IFIH1 loss-of-function mutations

Thomas Junier, Amalio Telenti, Samira Asgari, Jacques Fellay, Istvan Bartha, Paul Jack Mc Laren, Christian Hammer

Viral respiratory infections are usually mild and self-limiting; still they exceptionally result in life-threatening infections in previously healthy children. To investigate a potential genetic cause, we recruited 120 previously healthy children requiring ...

Natl Acad Sciences2017

Estimating the Respective Contributions of Human and Viral Genetic Variation to HIV Control

Amalio Telenti, Jacques Fellay, Istvan Bartha, Paul Jack Mc Laren

We evaluated the fraction of variation in HIV-1 set point viral load attributable to viral or human genetic factors by using joint host/pathogen genetic data from 541 HIV infected individuals. We show that viral genetic diversity explains 29% of the variat ...

Public Library of Science2017

Evaluating the Impact of Functional Genetic Variation on HIV-1 Control

Jacques Fellay, Istvan Bartha, Paul Jack Mc Laren

Previous genetic association studies of human immunodeficiency virus-1 (HIV-1) progression have focused on common human genetic variation ascertained through genome-wide genotyping. ...

Oxford Univ Press Inc2017

Privacy-preserving genomic testing in the clinic: a model using HIV treatment

Jean-Pierre Hubaux, Amalio Telenti, Jacques Fellay, Erman Ayday, Istvan Bartha, Paul Jack Mc Laren, Jean Louis Raisaro

The implementation of genomic-based medicine is hindered by unresolved questions regarding data privacy and delivery of interpreted results to health-care practitioners. We used DNA-based prediction of HIV-related outcomes as a model to explore critical is ...

Nature Publishing Group2016

Contribution of Genetic Background and Clinical Risk Factors to Low-Trauma Fractures in Human Immunodeficiency Virus (HIV)-Positive Persons: The Swiss HIV Cohort Study

Thomas Junier, Jacques Fellay, Istvan Bartha

Background. The impact of human genetic background on low-trauma fracture (LTF) risk has not been evaluated in the context of human immunodeficiency virus (HIV) and clinical LTF risk factors. Methods. In the general population, 6 common single-nucleotide p ...

Oxford University Press (OUP)2016

Exome Sequencing Reveals Primary Immunodeficiencies in Children with Community-Acquired Pseudomonas aeruginosa Sepsis

Christoph Berger, Richard Wong, Samira Asgari, Jacques Fellay, Istvan Bartha, Paul Jack Mc Laren

One out of three pediatric sepsis deaths in high income countries occur in previously healthy children. Primary immunodeficiencies (PIDs) have been postulated to underlie fulminant sepsis, but this concept remains to be confirmed in clinical practice. Pseu ...

Frontiers Media Sa2016

Corrigendum: Exome Sequencing reveals Primary immunodeficiencies in Children with Community-Acquired Pseudomonas aeruginosa Sepsis (vol 7, 357, 2016)

Christoph Berger, Richard Wong, Samira Asgari, Jacques Fellay, Istvan Bartha, Paul Jack Mc Laren

Frontiers Media Sa2016

Role of APOBEC3F Gene Variation in HIV-1 Disease Progression and Pneumocystis Pneumonia

Jacques Fellay, Istvan Bartha, Christian Axel Wandall Thorball

Human APOBEC3 cytidine deaminases are intrinsic resistance factors to HIV-1. However, HIV-1 encodes a viral infectivity factor (Vif) that degrades APOBEC3 proteins. In vitro APO-BEC3F (A3F) anti-HIV-1 activity is weaker than A3G but is partially resistant ...

Public Library of Science2016

Adaptation on a genomic scale

Jacques Fellay, Istvan Bartha

Sequencing the genome of Candida albicans as it evolves in a patient reveals the genetic changes that allow the yeast to adapt to its environment. ...

2015

Amino Acid Variation in HLA Class II Proteins Is a Major Determinant of Humoral Response to Common Viruses

Jacques Fellay, Istvan Bartha, Paul Jack Mc Laren, Christian Hammer

The magnitude of the human antibody response to viral antigens is highly variable. To explore the human genetic contribution to this variability, we performed genome-wide association studies of the immunoglobulin G response to 14 pathogenic viruses in 2,36 ...

Cell Press2015

The Characteristics of Heterozygous Protein Truncating Variants in the Human Genome

Amalio Telenti, Jacques Fellay, Istvan Bartha, Paul Jack Mc Laren, Nimisha Chaturvedi

Sequencing projects have identified large numbers of rare stop-gain and frameshift variants in the human genome. As most of these are observed in the heterozygous state, they test a gene's tolerance to haploinsufficiency and dominant loss of function. We a ...

Public Library Science2015

The Interplay Between Host Genetic Variation, Viral Replication, and Microbial Translocation in Untreated HIV-Infected Individuals

Amalio Telenti, Jacques Fellay, Istvan Bartha

Systemic immune activation, a major determinant of human immunodeficiency virus (HIV) disease progression, is the result of a complex interplay between viral replication, dysregulation of the immune system, and microbial translocation due to gut mucosal da ...

Oxford University Press2015

Polymorphisms of large effect explain the majority of the host genetic contribution to variation of HIV-1 virus load

Amalio Telenti, Jacques Fellay, Istvan Bartha, Paul Jack Mc Laren

Previous genome-wide association studies (GWAS) of HIV-1-infected populations have been underpowered to detect common variants with moderate impact on disease outcome and have not assessed the phenotypic variance explained by genome-wide additive effects. ...

National Academy of Sciences2015

Dynamics of HIV Latency and Reactivation in a Primary CD4+T Cell Model

Amalio Telenti, Julia di Iulio, Jacques Fellay, Istvan Bartha, Christian Axel Wandall Thorball

HIV latency is a major obstacle to curing infection. Current strategies to eradicate HIV aim at increasing transcription of the latent provirus. In the present study we observed that latently infected CD4+ T cells from HIV-infected individuals failed to pr ...

Public Library Science2014

Analysis of Stop-Gain and Frameshift Variants in Human Innate Immunity Genes

Amalio Telenti, Jacques Fellay, Istvan Bartha, Paul Jack Mc Laren, Ioannis Xenarios

Loss-of-function variants in innate immunity genes are associated with Mendelian disorders in the form of primary immunodeficiencies. Recent resequencing projects report that stop-gains and frameshifts are collectively prevalent in humans and could be resp ...

Public Library Science2014