Publications by Yingdi Zhu | EPFL Graph Search

Algorithms push forward the application of MALDI-TOF mass fingerprinting in rapid precise diagnosis

Macromolecular mass fingerprinting using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry is a quick tool for biochemical analysis. In combination with algorithms for automated data analysis and interpretation, it has wide appli ...

WILEY2023

MALDI-TOF Mass Fingerprinting for Rapid Identification of Bacteria: Experimental Procedures

Hubert Girault, Yingdi Zhu

Royal Society of Chemistry2023

In situ detection of multitarget impurities on contact lens by electrochemical scanning probe

Fang Liu, Tzu-En Lin, Yingdi Zhu

Identifying multitarget impurities on contact lenses is challenging because traditional methods such as polymerase chain reaction cannot be used on the unknown target. Other sampling methods often require expensive antibodies or dyes. Therefore, this resea ...

ELSEVIER SCIENCE SA2023

Rapid Noninvasive Skin Monitoring by Surface Mass Recording and Data Learning

Hubert Girault, Horst Pick, Natalia Gasilova, Andreas Stephan Lesch, Tzu-En Lin, Yingdi Zhu, Milica Jovic

Skin problems are often overlooked due to a lack of robust and patient-friendly monitoring tools. Herein, we report a rapid, noninvasive, and high-throughput analytical chemical methodology, aiming at real-time monitoring of skin conditions and early detec ...

2021

Highly Loaded Mildly Edge‐Oxidized Graphene Nanosheet Dispersions for Large‐Scale Inkjet Printing of Electrochemical Sensors

Hubert Girault, Horst Pick, Andreas Stephan Lesch, Victor Costa Bassetto, Yingdi Zhu, Milica Jovic, Bhawna Nagar

Inkjet printing of electrochemical sensors using a highly loaded mildly edge‐oxidized graphene nanosheet (EOGN) ink is presented. An ink with 30 mg/mL EOGNs is formulated in a mixture of N‐methyl pyrrolidone and propylene glycol with only 30 min of sonicat ...

2020

Skin cell analysis

Hubert Girault, Horst Pick, Andreas Stephan Lesch, Tzu-En Lin, Yingdi Zhu, Milica Jovic

The present invention describes an adhesive tape stripping transfer method for quick and non-invasive diagnosis of skin diseases by MALDI-TOF mass spectrometry analysis. Cells from the epidermis layer of a suspicious skin area of a patient are collected us ...

2020

MALDI Detection of Exosomes: A Potential Tool for Cancer Studies

Hubert Girault, Horst Pick, Natalia Gasilova, Tzu-En Lin, Yingdi Zhu

Matrix-assisted laser desorption ionization time-of-flight mass spectrometry is used to detect intact whole exosomes, yielding exosomal fingerprints within minutes. This rapid exosome detection approach is proposed as a potential tool for cancer studies. M ...

2019

Tape-Stripping Electrochemical Detection of Melanoma

Hubert Girault, Horst Pick, Andreas Stephan Lesch, Tzu-En Lin, Yingdi Zhu, Sorour Darvishi

A noninvasive electrochemical melanoma detection approach based on using adhesive tapes for collecting and fixing cells from a suspicious skin area and transferring the cells into a scanning electrochemical microscope (SECM) is presented. The adhesive laye ...

AMER CHEMICAL SOC2019

Mass Spectrometry Methods for Bacterial Infection Diagnosis and Cancer Analysis

Yingdi Zhu

Matrix-assisted laser desorption/ionisation (MALDI) time-of-flight (TOF) mass spectrometry is an important analytical tool in chemistry and biology. Bearing the advantages of easy-to-use, fast measurements and relatively simple data interpretation, MALDI-T ...

EPFL2019

Detection of bacteria

Hubert Girault, Horst Pick, Andreas Stephan Lesch, Yingdi Zhu, Milica Jovic

A method for bacteria detection and the assessment of the antimicrobial susceptibility profile uses a bacterial viability assay based on combining a highly efficient affinity bacteria enrichment/ separation with an electrochemical redox interrogation measu ...

2019

Detection of antimicrobial resistance-associated proteins by titanium dioxide-facilitated intact bacteria mass spectrometry

Hubert Girault, Horst Pick, Liang Qiao, Natalia Gasilova, Yingdi Zhu, Milica Jovic

Titanium dioxide-modified target plates were developed to enhance intact bacteria analysis by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. The plates were designed to photocatalytically destroy the bacterial envelope struct ...

2018

Maldi device and methods of preparation and use thereof

Hubert Girault, Horst Pick, Liang Qiao, Yingdi Zhu, Milica Jovic

A target plate for enhanced matrix-assisted laser desorption/ionization mass spectrometry (MALDI MS) analysis of intact biological entities. The target plate comprises an electrically conductive substrate (1) covered at least partially with immobilised pho ...

2018

Immuno-affinity Amperometric Detection of Bacterial Infections

Hubert Girault, Horst Pick, Michel Prudent, Andreas Stephan Lesch, Yingdi Zhu, Milica Jovic

A combination of an immuno-affinity enrichment strategy and sensitive amperometric read-out was implemented in a point-of-care platform intended for bacterial infection analysis. Bacterial cells, selectively captured and enriched from complex matrices thro ...

Wiley-VCH Verlag GmbH2018

Inkjet-printed microtiter plates for portable electrochemical immunoassays

Hubert Girault, Frédéric Gumy, Fernando Cortes Salazar, Andreas Stephan Lesch, Alexandra Bondarenko, Yingdi Zhu, Milica Jovic

Herein, we present the large-scale fabrication of multiplexed three-electrode sensors used in a point-of-care device platform that couples a magnetic bead-based immunoassay strategy with amperometric detection for rapid and highly sensitive analysis. The m ...

Elsevier Science Sa2017

Sensitive and fast identification of bacteria in blood samples by immunoaffinity mass spectrometry for quick BSI diagnosis

Hubert Girault, Horst Pick, Michel Prudent, Niels Erik Lion, Liang Qiao, Natalia Gasilova, Alexandra Bondarenko, Yingdi Zhu

Bloodstream infections rank among the most serious causes of morbidity and mortality in hospitalized patients, partly due to the long period (up to one week) required for clinical diagnosis. In this work, we have developed a sensitive method to quickly and ...

Royal Soc Chemistry2016